2015 Fiscal Year Final Research Report
Feasibility Study for the generation of live cell from extinct or endangered animal
| Project/Area Number |
23248048
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied animal science
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| Research Institution | University of Yamanashi (2012-2015)
The Institute of Physical and Chemical Research (2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIZUTANI Eiji 山梨大学, 総合研究部, 助教 (80443034)
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Keywords | クローン / 核移植 / 絶滅動物 / 絶滅危惧種 / 発生工学 |
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| Outline of Final Research Achievements |
One interesting application of nuclear transfer (NT) techniques is the resurrection of extinct species and the rescue of endangered species. However, current success rate for producing live animals by cloning is very low. Therefore, we tried to improve nuclear transfer procedure one by one, and applied this techniques to generate cloned mice from frozen cadaver or fur, or cells collected from excrement or urine. By using most recent nuclear transfer techniques, we could succeeded to generate cloned mice from somatic cells of cloned mice, and probably this process can repeat unlimitedly because we could not find any accumulation of abnormality in those re-cloned mice. On the other hand, we also succeeded to generate cloned mice from urine-derived cells. This suggest that cells derived from urine, which can be collected noninvasively, may be used in the rescue of endangered mammalian species by using nuclear transfer without causing injury to the animal.
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| Free Research Field |
発生工学 生殖生物学
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