The Fukuoka Diabetes Registry

2015 Fiscal Year Final Research Report

• Project/Area Number: 23249037
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Kyushu University
• Principal Investigator: Iwase Masanori 九州大学, 医学(系)研究科(研究院), 研究員 (00203381)
• Co-Investigator(Kenkyū-buntansha): KITAZONO Takanari 九州大学, 医学研究院, 教授 (70284487) ; KUBO Michiaki 理化学研究所, ゲノム医科学研究センター, センター長代行 (30442958) ; KIYOHARA Yutaka 九州大学, 医学研究院, 教授 (80161602) ; KANG Dongchon 九州大学, 医学研究院, 教授 (80214716) ; OHKUMA Toshiaki 九州大学, 医学研究院, 助教 (20709258) ; DOI Yasufumi 麻生飯塚病院, 医務室 (00419566)
• Co-Investigator(Renkei-kenkyūsha): SASAKI Satoshi 東京大学, 医学系研究科, 教授 (70275121) ; KANBA Shigenobu 九州大学, 医学研究院, 教授 (50195187)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Keywords: コホート研究 / 生活習慣病 / 低血糖 / 慢性腎臓病 / 睡眠 / 一塩基多型 / 肥満 / 遺伝子－環境相互作用

Outline of Final Research Achievements

Diabetes mellitus is rapidly epidemic in Japan, although its effective treatment remains to be established. Since the goal of treatment is to approximate the prognosis of diabetic patients to that of healthy subjects as close as possible, the prospective study to compare diabetic and nondiabetic subjects should be mandatory.
The database has been developed comprising 5,131 diabetic patients (The Fukuoka Diabetes Registry, follow-up period 5 years, follow-up rate 97%) and 3,351 community-dwelling residents including those with normal glucose tolerance (The Hisayama Study). We have investigated the lifestyle such as the speed of eating, intakes of dietary fiber and magnesium, physical activity, alcohol consumption, smoking, sleeping time, depressive symptoms and the accumulation of lifestyle risks, islet autoantibody in type 2 diabetic patients, genetic variants susceptible to type 2 diabetes, severe hypoglycemia, chronic kidney disease, cancer, and gene-environment interactions.

Free Research Field

糖尿病学