Host and parasite genetic factors that influence the reactivity to Benznidazol treatment of the peadiatric chronic Chagas patients in Bolivia

2014 Fiscal Year Final Research Report

• Project/Area Number: 23256003
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Parasitology (including Sanitary zoology)
• Research Institution: Nagasaki University
• Principal Investigator: HIRAYAMA Kenji 長崎大学, 熱帯医学研究所, 教授 (60189868)
• Co-Investigator(Kenkyū-buntansha): NARA Takeshi 順天堂大学, 大学院医学研究科, 准教授 (40276473) ; NGUYEN Huytien 長崎大学, 熱帯医学研究所, 准教授 (20457526) ; KIKUCHI Mihoko 長崎大学, 熱帯医学研究所, 講師 (40336186)
• Co-Investigator(Renkei-kenkyūsha): MAEMURA Koji 長崎大学, 医歯薬学総合研究科(医学系), 教授 (90282649)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: シャーガス病 / ボリビア / ベンズニダゾール / 治療効果 / 遺伝子多型解析

Outline of Final Research Achievements

In collaboration with the governmental Chagas control program in Bolivia, one year longitudinal hospital cohort study was performed to assess the host genetic factors on the reactivity to 2 months regimen of Benznidazol for the 77 peadiatric chagas patients. The clinical records and laboratory data including specific antibody titer, parasite qPCR, plasma levels of BNZ and cytokines were monitored and used for the evaluation of their reactivity to the treatment. They were divided into three groups 1)effective, 2)less effective, 3)side effect. Host DNA were analyzed for the HLA, P-450 enzymes, genes polymorphism to see their influence on the reactivity to BNZ.

Free Research Field

寄生虫学分野