Development of protein-carbohydrate binding prediction systems and databases

2014 Fiscal Year Final Research Report

• Project/Area Number: 23300109
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Bioinformatics/Life informatics
• Research Institution: The University of Tokyo
• Principal Investigator: SHIMIZU Kentaro 東京大学, 農学生命科学研究科, 教授 (80178970)
• Co-Investigator(Kenkyū-buntansha): TERADA Tohru 東京大学, 大学院農学生命科学研究科, 准教授 (40359641) ; SUMIKOSHI Kazuya 東京大学, 大学院農学生命科学研究科, 助教 (90431832)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: タンパク質 / 糖鎖 / 相互作用予測 / データベース / バイオインフォマティクス

Outline of Final Research Achievements

In this study, we developed the prediction methods of carbohydrate binding proteins (predicting whether a given protein binds to the carbohydrate), protein-carbohydrate binding sites (predicting which residues bind to the carbohydrate), binding carbohydrates (predicting what kinds of carbohydrate bind to a given protein), complex structures of protein and carbohydrate, glycosylation sites. We also developed the comprehensive databases of protein-carbohydrates which contain sequences, structures, binding ligands, and a variety of information about the function.

Free Research Field

生命情報科学