Study on the molecular/neural basis underlying social behavior in medaka fish

2013 Fiscal Year Final Research Report

• Project/Area Number: 23300115
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: The University of Tokyo
• Principal Investigator: TAKEUCHI Hideaki 東京大学, 理学(系)研究科(研究院), 助教 (00376534)
• Co-Investigator(Renkei-kenkyūsha): KAMEI Yasuhiro 基礎生物学研究所, 光学解析室, 特任准教授 (70372563)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Keywords: 社会脳

Research Abstract

Medaka females recognize familiar males following prior visual exposure, and prefer to mate with the familiarized males. A subpopulation of gonadotropin-releasing hormone-producing neurons (GnRH3 neurons) is essential for the decision-making switch in the mating choice.

Research Products

• [Journal Article] A neural mechanism underlying mating preferences for familiar individuals in medaka fish (2014)
  • Author(s): Okuyama T, Yokoi S, Abe H, Suehiro Y, Imada H, Tanaka M, Kawasaki T, Yuba S, Taniguchi Y, Kamei Y, Okubo K, Shimada A, Naruse K, Takeda H, Oka Y, Kubo T, and Takeuchi H
  • Journal Title: Science Volume: 343 Pages: 91-94
  • Peer Reviewed
• [Journal Article] A new data-mining method to search for behavioral properties that induce coordinated movements and their involvement in social learning in medaka fish (Oryzias Latipes) (2013)
  • Author(s): Ochiai T, Suehiro Y, Nishinari K, Kubo T, and Takeuchi H
  • Journal Title: PLoS ONE Volume: 8 Pages: e71685
  • Peer Reviewed
• [Journal Article] Controlled Cre/loxP site-specific recombination in the developing brain in medaka fish, Oryzias latipes (2013)
  • Author(s): Okuyama T, Isoe Y, Hoki M, Suehiro Y, Yamagishi G, Tanaka M, Naruse K, Kinoshita M, Kamei Y, Shimizu A, Kubo T, and Takeuchi H
  • Journal Title: PLoS ONE Volume: 8 Pages: e66597
  • Peer Reviewed
• [Journal Article] p53 mutation suppresses adult neurogenesis in medaka fish (Oryzias latipes) (2012)
  • Author(s): Isoe Y, Okuyama T, Taniguchi Y, Kubo T, and Takeuchi H
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 423 Pages: 627-631
  • Peer Reviewed
• [Journal Article] Induction of c-fos transcription in the medaka brain (Oryzias latipes) in response to mating stimuli (2011)
  • Author(s): Okuyama T, Suehiro Y, Imada H, Shimada A, Naruse K, Takeda H, Kubo T, and Takeuchi H
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 404 Pages: 453-457
  • Peer Reviewed
• [Presentation] メダカを用いた配偶者防衛行動の神経基盤解析 (2013)
  • Author(s): 横井佐織, 奥山輝大, 亀井保博, 谷口善仁, 安齋賢, 木下政人, 久保健雄, 竹内秀明
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸市,神戸ポートピア
  • Year and Date: 2013-12-03
• [Presentation] Neural mechanism underlying socially-regulated female mating receptivity in medaka fish (2013)
  • Author(s): Teruhiro Okuyama, Saori Yokoi, Hideki Abe, Yasuko Isoe, Yuji Suehiro, Haruka Imada, Minoru Tanaka, Takashi Kawasaki, Shunsuke Yuba, Yoshihito Taniguchi, Yasuhiro Kamei, Kataaki Okubo, Atsuko Shimada, Kiyoshi Naruse, Hiroyuki Takeda, Yoshitaka Oka, Takeo Kubo, Hideaki Takeuchi
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸ポートピア
  • Year and Date: 2013-12-03
• [Presentation] A heat-inducible cre/loxp recombination in the brain of medaka fish (Oryzias latipes) (2013)
  • Author(s): Isoe, Y., Okuyama, T.,Hoki, M., Suehiro, Y., Yamagishi, G., Naruse, K., Kinoshita, M., Kamei, Y., Shimizu, A., Kubo, T., Takeuchi, H.
  • Organizer: The 42nd annual meeting of the Society for Neuroscience meeting 2013
  • Place of Presentation: San Diego
  • Year and Date: 2013-11-12
• [Presentation] Analysis of neural basis of mate-guarding behavior in small fish, medaka (2013)
  • Author(s): Saori Yokoi, Teruhiro Okuyama, Yasuhiro Kamei, Yoshihito Taniguchi Takeo Kubo, Hideaki Takeuchi
  • Organizer: The 42th annual meeting of the Society for Neuroscience meeting 2013
  • Place of Presentation: San Diego
  • Year and Date: 2013-11-12
• [Presentation] メダカ近交系を用いた視覚刺激依存の驚愕反応特性に影響する遺伝子の探索 (2013)
  • Author(s): 坪子理美, 木村哲晃, 新屋みのり, 末廣勇司, 奥山輝大, 島田敦子, 武田洋幸, 成瀬清, 久保健雄, 竹内秀明
  • Organizer: 第84回日本動物学会岡山大会
  • Place of Presentation: 岡山市,岡山大学津島キャンパス
  • Year and Date: 2013-09-26
• [Presentation] A heat-inducible cre/loxp recombination in the brain of medaka fish (Oryzias latipes) (2013)
  • Author(s): Isoe, Y., Okuyama, T.,Hoki, M., Suehiro, Y., Yamagishi, G., Naruse, K., Kinoshita, M., Kamei, Y., Shimizu, A., Kubo, T., Takeuchi, H
  • Organizer: 第19回小型魚類研究会
  • Place of Presentation: 仙台市,仙台市情報・産業プラザ
  • Year and Date: 2013-09-20
• [Presentation] Analysis of neural/molecular mechanisms of mate-guarding behavior in small fish, medaka (2013)
  • Author(s): Saori Yokoi, Teruhiro Okuyama, Yasuhiro Kamei, Yoshihito Taniguchi, Satoshi Ansai, Masato Kinoshita, Takeo Kubo, Hideaki Takeuchi
  • Organizer: 第19回小型魚類研究会
  • Place of Presentation: 仙台市,仙台市情報・産業プラザ
  • Year and Date: 2013-09-20
• [Presentation] Searching for genes affecting visually-evoked startle response properties with medaka inbred strains (2013)
  • Author(s): Satomi Tsuboko, Tetsuaki Kimura, Minori Shinya, Yuji Suehiro, Teruhiro Okuyama, Atsuko Shimada, Hiroyuki Takeda, Kiyoshi Naruse, Takeo Kubo, Hideaki Takeuchi
  • Organizer: 第19回小型魚類研究会
  • Place of Presentation: 仙台市,仙台市情報・産業プラザ
  • Year and Date: 2013-09-20
• [Presentation] Socially-regulated mating preference in medaka fish and its neural mechanism (2013)
  • Author(s): Hideaki Takeuchi
  • Organizer: 日本比較生理生化学会2013年大会
  • Place of Presentation: 姫路
  • Year and Date: 2013-07-13
• [Presentation] A heat-inducible cre/loxp recombination in the brain of medaka fish (Oryzias latipes) (2012)
  • Author(s): Isoe, Y., Okuyama, T.,Hoki, M., Suehiro, Y., Yamagishi, G., Naruse, K., Kinoshita, M., Kamei, Y., Shimizu, A., Kubo, T., Takeuchi, H
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸市,神戸ポートピア
  • Year and Date: 2012-12-03
• [Presentation] Integrative analysis of sexual behaviors in medaka fish : From neurons to behavioral evolution (2012)
  • Author(s): Hideaki Takeuchi
  • Organizer: Workshop "Evolution of the Brain" supported by CPIS, SOKENDAI
  • Place of Presentation: 葉山
  • Year and Date: 2012-11-23
• [Presentation] Analysis of the neural basis of mate-guarding behavior in small fish, medaka (2012)
  • Author(s): Yokoi, S., Okuyama, T., Kamei, Y., Taniguchi, Y., Kubo, T. and Takeuchi, H
  • Organizer: The 42th annual meeting of the Society for Neuroscience meeting 2012
  • Place of Presentation: New Orleans
  • Year and Date: 2012-10-15
• [Presentation] Analysis of mechanism underlying brain growth accompanied by neurogenesis using young medaka fish (Oryzias latipes) (2012)
  • Author(s): Isoe, Y., Okuyama, T., Houki, M., Suehiro, Y., Taniguchi, Y., Kubo, T. and Takeuchi, H.
  • Organizer: The 42th annual meeting of the Society for Neuroscience meeting 2012
  • Place of Presentation: New Orleans
  • Year and Date: 2012-10-15
• [Presentation] Neural mechanisms of female sexual preference in medaka (2012)
  • Author(s): Okuyama, T., Yokoi, T., Abe, T., Taniguchi, Y., Okubo, T., Kamei, Y., Shimada, A., Naruse, K., Takeda, H., Oka, Y., Kubo, T. and Takeuchi, H
  • Organizer: The 42th annual meeting of the Society for Neuroscience meeting 2012
  • Place of Presentation: New Orleans
  • Year and Date: 2012-10-15
• [Presentation] メダカにおける,メスの配偶者選択行動の神経機構 (2012)
  • Author(s): 奥山輝大, 横井佐織, 阿部秀樹, 末廣勇司, 今田はるか, 田中実, 川崎隆史, 谷口善仁, 亀井保博, 島田 敦子, 成瀬清, 武田洋幸, 岡良隆, 久保健雄, 竹内秀明
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-20
• [Presentation] メダカ近交系を用いた視覚刺激依存の驚愕 反応特性に影響する遺伝子の探索 (2012)
  • Author(s): 坪子理美, 木村哲晃, 新屋みのり, 末廣勇司, 奥山輝大, 島田敦子, 武田洋幸, 成瀬清, 久保健雄, 竹内 秀明
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-20
• [Presentation] メダカを用いた配偶者防衛行動の神経基盤解析 (2012)
  • Author(s): 横井佐織, 奥山輝大, 亀井保博, 谷口 善仁, 久保 健雄, 竹内秀明
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-20
• [Presentation] メダカ幼魚を用いた神経新生を伴う脳成長機構の解析 (2012)
  • Author(s): 磯江泰子, 奥山輝大, 谷口善仁, 久保健雄, 竹内秀明
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-20
• [Presentation] 小型魚類を用いた視覚情報依存的な配偶者選択行動の分子・神経基盤解析 (2011)
  • Author(s): 奥山輝大, 阿部秀樹, 末廣勇司, 今田はるか, 島田敦子, 川崎隆史, 弓場俊輔, 谷口善仁, 亀井保博, 田中実, 成瀬清, 武田洋幸, 岡良隆, 久保健雄, 竹内秀明
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜市,パシフィコ横浜
  • Year and Date: 2011-12-13
• [Presentation] Searching for genes affecting visually-evoked startle response properties in Medaka (Oryzias latipes) (2011)
  • Author(s): 坪子理美, 木村 哲晃, 末廣 勇司, 奥山 輝大, 島田 敦子, 武田 洋幸,成瀬 清,久保 健雄,竹内 秀明
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜市,パシフィコ横浜
  • Year and Date: 2011-12-13
• [Presentation] メダカ集団を用いた視覚連合学習を定量化する新規実験系の確立 (2011)
  • Author(s): 落合崇, 末廣勇司, 久保健雄, 竹内秀明
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜市,パシフィコ横浜
  • Year and Date: 2011-12-13
• [Presentation] メダカを用いた,配偶者防衛行動の分子・神経基盤解析 (2011)
  • Author(s): 横井佐織, 奥山輝大, 久保健雄, 竹内秀明
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜市,パシフィコ横浜
  • Year and Date: 2011-12-13
• [Presentation] p53 mutation caused suppression of neurogenesis in the juvenile medaka fish brain (2011)
  • Author(s): Isoe, Y., Okuyama, T., Taniguchi, Y., Kubo, T. and Takeuchi, H
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜市,パシフィコ横浜
  • Year and Date: 2011-12-13
• [Presentation] Neural basis underlying sexual selection in medaka fish (2011)
  • Author(s): Hideaki Takeuchi
  • Organizer: The 1st Strategic Meeting for Medaka Research, National Institute for Basic Biology
  • Place of Presentation: 岡崎
  • Year and Date: 2011-11-23
• [Presentation] p53 mutation caused suppression of neurogenesis in the juvenile medaka fish brain (2011)
  • Author(s): Isoe, Y., Okuyama, T., Taniguchi, Y., Kubo, T. and Takeuchi, H
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜市,パシフィコ横浜
  • Year and Date: 2011-09-20
• [Presentation] メダカを用いた配偶者防衛行動の神経基盤解析 (2011)
  • Author(s): 横井佐織, 奥山輝大, 久保健雄, 竹内秀明
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜市,パシフィコ横浜
  • Year and Date: 2011-09-20
• [Presentation] Analysis of the molecular and neural mechanism of female sexual preference that depends on visual information in small fish medaka (2011)
  • Author(s): Okuyama, T., Abe, H., Suehiro, Y., Imada, H., Shimada, A., Kawasaki, T., Yuba, S., Taniguchi, Y., Kamei, Y., Tanaka, M., Naruse, K., Takeda, H., Oka, Y., Kubo, T. and Takeuchi, H
  • Organizer: 第17回小型魚類研究会
  • Place of Presentation: 三島市,東レ総合研修センター
  • Year and Date: 2011-09-20
• [Presentation] Neural basis underlying sexual selection in medaka fish (2011)
  • Author(s): Hideaki takeuchi
  • Organizer: The 34th Annual Meeting of the Japan Neuroscience Society "Vertebrate brain functions elucidated in zebrafish and medaka"
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-15
• [Presentation] p53 mutation caused suppression of neurogenesis in the juvenile medaka fish brain (2011)
  • Author(s): Isoe, Y., Okuyama, T., Taniguchi, Y., Kubo, T. and Takeuchi, H
  • Organizer: 第17回小型魚類研究会
  • Place of Presentation: 三島市,東レ総合研修センター
  • Year and Date: 2011-09-09
• [Presentation] Analysis of neural basis for mate guarding behavior, using small fish medaka (2011)
  • Author(s): 横井佐織, 奥山輝大, 久保健雄, 竹内秀明
  • Organizer: 第17回小型魚類研究会
  • Place of Presentation: 三島市,東レ総合研修センター
  • Year and Date: 2011-09-09
• [Presentation] Searching for genes affecting visually-evoked startle response properties in Medaka (2011)
  • Author(s): 坪子理美, 木村 哲晃, 末廣 勇司, 奥山 輝大, 島田 敦子, 武田 洋幸, 成瀬 清, 久保 健雄, 竹内 秀明
  • Organizer: 第17回小型魚類研究会
  • Place of Presentation: 三島市,東レ総合研修センター
  • Year and Date: 2011-09-09
• [Presentation] Neural basis underlying female mating preference in medaka fish (2011)
  • Author(s): Hideaki Takeuchi
  • Organizer: The 8th International Congress on Comparative Physiology and Biochemistry
  • Place of Presentation: 名古屋
  • Year and Date: 2011-06-02