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2013 Fiscal Year Final Research Report

Experiment research on the therapeutic impact of low-magnitude vibrations on eraly-stage bone healing

Research Project

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Project/Area Number 23300165
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionOsaka University

Principal Investigator

MATSUMOTO Takeshi  大阪大学, 基礎工学研究科, 准教授 (30249560)

Co-Investigator(Kenkyū-buntansha) TANAKA Masao  大阪大学, 基礎工学研究科, 教授 (40163571)
NAKAMURA Masanori  埼玉大学, 理工学研究科, 准教授 (20448046)
YASUI Takeshi  徳島大学, ソシオテクノサイエンス研究部, 教授 (70314408)
Co-Investigator(Renkei-kenkyūsha) UESUGI Kentaro  高輝度光科学研究センター, 研究員 (80344399)
Project Period (FY) 2011-04-01 – 2014-03-31
Keywords骨折修復 / 血管新生 / 高周波微振動 / 放射光CT
Research Abstract

Promotion of bone healing is favorable for preventing the elderly from falling into osteoporosis, a bedridden state, or situation necessitating nursing care. This study was undertaken to evaluate the effect of low-magnitude whole-body vibration (WBV) on early-stage bone healing, mainly focusing on angiogenesis. Mice subjected to a drill-hole surgery on a tibial diaphysis were exposed to 0.3g WBV at 30 Hz for 20 min/day over a 12-day period. Following vascular casting, the defect site was CT-scanned by synchrotron light. Structural analysis suggests the WBV-induced promotion of the defect repair with reduced angiogenesis. In addition, the second harmonic generation microscopy showed that WBV had no effect on collagen synthesis. Furthermore, the enhancement of angiogenesis under WBV did not increase the promotion effect of WBV on bone healing.

  • Research Products

    (13 results)

All 2014 2013 2012

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (6 results) (of which Invited: 1 results) Book (2 results)

  • [Journal Article] Second Harmonic Generation Microscopy and Synchrotron Radiation CT for the Determination of Collagen and Mineral Deposition in Early-Stage Bone Repair : Effect of Whole Body Micro-Vibration2014

    • Author(s)
      Y. Hashimoto, S. Fukushima, T. Matsumoto, H. Naito, M. Tanaka
    • Journal Title

      Adv. Biomed. Eng

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] In Vivo Visualization of Dermal Collagen Fiber in Skin Burn by Collagen-Sensitive Second-Harmonic- Generation Microscopy2013

    • Author(s)
      R. Tanaka, S. Fukushima, K. Sasaki, Y. Tanaka, H. Murota, T. Matsumoto, T. Araki, T. Yasui
    • Journal Title

      J. Biomed. Opt

      Volume: vol. 18 Pages: 061231-1-8

    • Peer Reviewed
  • [Journal Article] Estimation of Change of Bone Structures After Total Hip Replacement Using Bone Remodeling Simulation2013

    • Author(s)
      J. Kwon, H. Naito, T. Matsumoto, M. Tanaka
    • Journal Title

      Clin. Biomech

      Volume: vol. 28 Pages: 514-518

    • Peer Reviewed
  • [Journal Article] Beneficial effects of vitamin K on morphometric and material bone properties during growth2013

    • Author(s)
      T. Matsumoto
    • Journal Title

      SPring-8 Research Frontiers

      Volume: vol. 2012 Pages: 38-39

  • [Journal Article] Subtraction Micro-Computed Tomography of Angiogenesis and Osteogenesis During Bone Repair Using Synchrotron Radiation With a Novel Contrast Agent2013

    • Author(s)
      T. Matsumoto, D. Goto, S. Sato
    • Journal Title

      Lab. Invest

      Volume: vol. 93 Pages: 1054-1063

    • Peer Reviewed
  • [Presentation] 放射光CT による骨の形態・生理解析2014

    • Author(s)
      松本健志
    • Organizer
      第27回日本放射光学会年会・放射光科学合同シンポジウム
    • Place of Presentation
      広島
    • Year and Date
      20140000
  • [Presentation] Quantitative Bone CT Using Synchrotron Source2013

    • Author(s)
      T. Matsumoto
    • Organizer
      Proc. 2013 Spring Meeting of Bioeng. Div. KSME
    • Place of Presentation
      Yeosu
    • Year and Date
      20130000
    • Invited
  • [Presentation] Deferoxamine Alleviates Unloading-Induced Delay of Bone Defect Repair2013

    • Author(s)
      T. Matsumoto, S. Sato, D. Goto
    • Organizer
      Proc. 2nd Joint Meeting of IBMS and JSBMR
    • Place of Presentation
      Kobe
    • Year and Date
      20130000
  • [Presentation] Involvement of Angiogenesis in Early-Stage Bone Repair.2013

    • Author(s)
      S. Sato, T. Matsumoto, H. Naito, M. Tanaka
    • Organizer
      Proc. 35th Ann. Int. Conf. IEEE Eng. Med. Biol
    • Place of Presentation
      Osaka
    • Year and Date
      20130000
  • [Presentation] Hypoxia-Inducible Factor-Mediated Enhancement of Angiogenesis Reduces the delay of bone defect healing caused by mechanical unloading2012

    • Author(s)
      T. Matsumoto, S. Sato, D. Goto
    • Organizer
      Proc. Physiology
    • Place of Presentation
      Edinburgh
    • Year and Date
      20120000
  • [Presentation] 低酸素誘導因子による血管新生促進は除荷による骨修復遅延を改善する2012

    • Author(s)
      松本健志, 佐藤翔太, 後藤大智
    • Organizer
      第14回日本骨粗鬆症学会
    • Place of Presentation
      新潟
    • Year and Date
      20120000
  • [Book] 放射光CT による皮質骨ポア構造解析 (中村利孝 (編著):最新の骨粗鬆症学)2013

    • Author(s)
      松本健志
    • Total Pages
      63-67
    • Publisher
      日本臨牀社
  • [Book] Osteocyte Apoptosis- Induced Bone Resorption in Mechanical Remodeling Simulation - Computational Model for Trabecular Bone Structure (in T.M. Ntuli (ed.): Apoptosis and medicine)2012

    • Author(s)
      J. Kwon, 他
    • Total Pages
      25-46
    • Publisher
      InTech

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Published: 2015-06-25  

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