Habitual physical activity and healthy aging for older adults.

2013 Fiscal Year Final Research Report

• Project/Area Number: 23300259
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• Principal Investigator: AOYAGI Yukitoshi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 専門副部長 (50202495)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Keywords: 加齢・老化 / 日常身体活動 / 健康寿命

Research Abstract

Daily 24-h accelerometer data, collected continuously for 10 years, were categorized into activity quartiles. Final lean mass was greater for the third activity quartile (men and women with respective mean counts of 7,800 and 7,700 steps/day or mean duration of exercise at >3 metabolic equivalents (METs) of 20 and 17 min/day) than for the first and second quartiles. A proportional hazards model predicted that, over the 10 years, men and women in the two lowest activity quartiles (<6,700 and <6,800 steps/day) were 2.3 and 3.0 times as likely, respectively, to be sarcopenic as those in the highest activity quartile (>9,000 and >8,400 steps/day). Likewise, men and women with <16 and <14 min/day, respectively, of activity >3 METs were 3.0 and 3.5 times as likely to develop sarcopenia as those with >28 and >22 min/day. The risk of developing sarcopenia was substantially lower in elderly people taking at least 7,000-8,000 steps/day or exercising for at least 15-20 min/day at >3 METs.

Research Products

• [Journal Article] Objectively measured physical activity and progressive loss of lean tissue in older Japanese adults : longitudinal data from the Nakanojo Study (2013)
  • Author(s): Shephard R.J., Park H., Park S., Aoyagi Y
  • Journal Title: J Am Geriatr Soc Volume: 61(11) Pages: 1887-1893
  • Peer Reviewed
• [Journal Article] Sex differences in relationships between habitual physical activity and health in the elderly : Practical implications for epidemiologists based on pedometer/ accelerometer data from the Nakanojo Study (2013)
  • Author(s): Aoyagi Y., Shephard R.J
  • Journal Title: Arch Gerontol Geriatr Volume: 56(2) Pages: 327-338
  • Peer Reviewed
• [Journal Article] Sex differences in habitual physical activity of the elderly : Issues of measurement, activity patterns, barriers and health response (2013)
  • Author(s): Shephard R.J., Aoyagi Y
  • Journal Title: Health Fitness J Can Volume: 6 Pages: 3-71
  • Peer Reviewed
• [Journal Article] Identification of chromosome 3q28 and ALPK1 as susceptibility loci for chronic kidney disease in Japanese individuals by a genome-wide association study (2013)
  • Author(s): Yamada Y., Nishida T., Ichihara S., Kato K., Fujimaki T., Oguri M., Horibe H., Yoshida T., Watanabe S., Satoh K., Aoyagi Y., 他2名
  • Journal Title: J Med Genet Volume: 50(6) Pages: 410-418
  • Peer Reviewed
• [Journal Article] Synergistic effects of genetic variants of APOA5 and BTN2A1 on dyslipidemia or metabolic syndrome (2012)
  • Author(s): Hiramatsu M., Oguri M., Kato K., Horibe H., Fujimaki T., Watanabe S., Satoh K., Aoyagi Y., 他5名
  • Journal Title: Int J Mol Med Volume: 30(1) Pages: 185-192
  • Peer Reviewed
• [Journal Article] Measurement of human energy expenditure, with particular reference to field studies : an historical perspective (2012)
  • Author(s): Shephard R.J., Aoyagi Y
  • Journal Title: Eur J Appl Physiol Volume: 112(8) Pages: 2785-2815
  • Peer Reviewed
• [Journal Article] Habitual physical activity and health : the Nakanojo Study (2011)
  • Author(s): Aoyagi Y
  • Journal Title: Health Fitness J Can Volume: 4(1) Pages: 9-12
  • Peer Reviewed
• [Journal Article] A model to estimate the potential for a physical activity-induced reduction in healthcare costs for the elderly, based on pedometer/accelerometer data from the Nakanojo Study (2011)
  • Author(s): Aoyagi Y., Shephard R. J
  • Journal Title: Sports Med Volume: 41(9) Pages: 695-708
  • Peer Reviewed
• [Journal Article] Association of a polymorphism of BTN2A1 with dyslipidemia in East Asian populations (2011)
  • Author(s): Fujimaki T., Kato K., Oguri M., Yohida T., Horibe H., Yokoi K., Watanabe S., Satoh K., Aoyagi Y., 他8名
  • Journal Title: Exp Ther Med Volume: 2(4) Pages: 745-749
  • Peer Reviewed
• [Journal Article] Association of a polymorphism of BTN2A1 with type 2 diabetes mellitus in Japanese individuals (2011)
  • Author(s): Hiramatsu M., Oguri M., Kato K., Yoshida T., Fujimaki T., Horibe H., Yokoi K., Watanabe S., Satoh K., Aoyagi Y., 他6名
  • Journal Title: Diabet Med Volume: 28(11) Pages: 1381-1387
  • Peer Reviewed
• [Journal Article] Association of a polymorphism of BTN2A1 with hypertension in Japanese individuals (2011)
  • Author(s): Horibe H., Kato K., Oguri M., Yoshida T., Fujimaki T., Kawamiya T., Yokoi K., Watanabe S., Satoh K., Aoyagi Y., 他6名
  • Journal Title: Am J Hypertens Volume: 24(8) Pages: 924-929
  • Peer Reviewed
• [Journal Article] Association of a genetic variant of BTN2A1 with metabolic syndrome in East Asian populations (2011)
  • Author(s): Oguri M., Kato K., Yoshida T., Fujimaki T., Horibe H., Yokoi K., Watanabe S., Satoh K., Aoyagi Y., 他8名
  • Journal Title: J Med Genet Volume: 48(11) Pages: 787-792
  • Peer Reviewed
• [Journal Article] How many steps/day are enough? For older adults and special populations (2011)
  • Author(s): Tudor-Locke C., Craig CL., Aoyagi Y., Bell RC., Croteau KA., De Bourdeaudhuij I., Ewald B., Gardner AW., Hatano Y., Lutes LD., Matsudo SM., Ramirez-Marrero FA., Rogers LQ., Rowe DA., Schmidt MD., Tully MA., Blair SN
  • Journal Title: Int J Behav Nutr Phys Act Volume: 8 Pages: 80
  • Peer Reviewed
• [Journal Article] Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations (2011)
  • Author(s): Yamada Y., Nishida T., Ichihara S., Sawabe M., Fuku N., Nishigaki Y., Aoyagi Y., 他20名
  • Journal Title: Atherosclerosis Volume: 215(1) Pages: 145-152
  • Peer Reviewed
• [Journal Article] Association of a genetic variant of BTN2A1 with chronic kidney disease in Japanese individuals (2011)
  • Author(s): Yoshida T., Kato K., Horibe H., Oguri M., Fukuda M., Satoh K., Aoyagi Y., 他3名
  • Journal Title: Nephrology (Carlton) Volume: 16(7) Pages: 642-648
  • Peer Reviewed
• [Journal Article] Association of a polymorphism of BTN2A1 with chronic kidney disease in individuals with or without hypertension or diabetes mellitus (2011)
  • Author(s): Yoshida T., Kato K., Oguri M., Horibe H., Kawamiya T., Yokoi K., Fujimaki T., Watanabe S., Satoh K., Aoyagi Y., 他5名
  • Journal Title: Exp Ther Med Volume: 2(2) Pages: 325-331
  • Peer Reviewed
• [Journal Article] Association of polymorphisms of BTN2A1 and ILF3 with myocardial infarction in Japanese individuals with different lipid profiles (2011)
  • Author(s): Yoshida T., Kato K., Oguri M., Horibe H., Kawamiya T., Yokoi K., Fujimaki T., Watanabe S., Satoh K., Aoyagi Y., 他5名
  • Journal Title: Mol Med Rep Volume: 4(3) Pages: 511-518
  • Peer Reviewed
• [Journal Article] Association of polymorphisms of BTN2A1 and ILF3 with myocardial infarction in Japanese individuals with or without hypertension, diabetes mellitus or chronic kidney disease (2011)
  • Author(s): Yoshida T., Kato K., Oguri M., Horibe H., Kawamiya T., Yokoi K., Fujimaki T., Watanabe S., Satoh K., Aoyagi Y., 他5名
  • Journal Title: Int J Mol Med Volume: 27(5) Pages: 745-752
  • Peer Reviewed
• [Journal Article] Associations of Activity Monitor Output and an Estimate of Aerobic Fitness with Pulse Wave Velocities : The Nakanojo Study
  • Author(s): Ayabe M., Park S., Shephard R.J., Aoyagi Y
  • Journal Title: J Aging Phys Act Volume: (In press)
  • Peer Reviewed
• [Presentation] Habitual Physical Activity and Immunological Function in Older Individuals : Preliminary Findings from The Nakanojo Study (2013)
  • Author(s): Aoyagi Y., Ayabe M., Park S., Kawakami H., Kuwata H., Shephard R.J
  • Organizer: 3rd International Conference on Ambulatory Monitoring of Physical Activity and Movement2013
  • Place of Presentation: Massachusetts, USA
  • Year and Date: 20130617-19
• [Presentation] Associations of Pedometer/accelerometer Data and MaximalWalking Speeds with PulseWave Velocities : The Nakanojo Study (2013)
  • Author(s): Ayabe M., Park S., Shephard R.J., Aoyagi Y
  • Organizer: 3rd International Conference on Ambulatory Monitoring of Physical Activity and Movement 2013
  • Place of Presentation: Massachusetts, USA
  • Year and Date: 20130617-19
• [Presentation] Objectively Measured Physical Activity and Calcaneal Bone Health in Older Japanese Adults : The Nakanojo Study (2013)
  • Author(s): Park H., Shephard R.J., Park S., Aoyagi Y
  • Organizer: 3rd International Conference on Ambulatory Monitoring of Physical Activity and Movement 2013
  • Place of Presentation: Massachusetts, USA
  • Year and Date: 20130617-19
• [Presentation] Objectively Measured Physical Activity and Appendicular Lean Tissue in Older Japanese Adults : The Nakanojo Study (2013)
  • Author(s): Shephard R.J., Park H., Park S., Aoyagi Y
  • Organizer: 3rd International Conference on Ambulatory Monitoring of Physical Activity and Movement 2013
  • Place of Presentation: Massachusetts, USA
  • Year and Date: 20130617-19
• [Presentation] Effect of enteric-coated lactoferrin supplementation on immune markers in serum of healthy elderly individuals : a randomized, double-blind, placebo-controlled trial (2013)
  • Author(s): Kawakami H., Park H., Park S., Kuwata H., Aoyagi Y
  • Organizer: The 11th International Conference on Lactoferrin : Structure, Function, and Application
  • Place of Presentation: Roma, Italia
  • Year and Date: 20130000
• [Presentation] 健康長寿の実現に最適な日常身体活動の量と質 : 中之条研究「10 年の成果」 (2013)
  • Author(s): 青柳幸利
  • Organizer: 運動疫学研究会
  • Place of Presentation: 国立健康・栄養研究所
  • Year and Date: 2013-09-20
• [Presentation] Habitual physical activity and health in the elderly : the Nakanojo Study (2011)
  • Author(s): Aoyagi Y
  • Organizer: The 2nd International Conference on the Ambulatory Monitoring of Physical Activity and Movement 2011
  • Place of Presentation: Glasgow, United Kingdom
  • Year and Date: 20110524-27
• [Presentation] Objectively measured physical activity and metabolic syndrome in older Japanese adults : longitudinal data from the Nakanojo Study (2011)
  • Author(s): Park S, Park H, Yoshiuchi K, Shephard R.J, and Aoyagi Y
  • Organizer: The 2nd International Conference on the Ambulatory Monitoring of Physical Activity and Movement 2011
  • Place of Presentation: Glasgow, United Kingdom
  • Year and Date: 20110524-27
• [Presentation] Objectively measured physical activity and sarcopenia in older Japanese adults : longitudinal data from the Nakanojo Study (2011)
  • Author(s): Park H, Park S, Shephard R.J, and Aoyagi Y
  • Organizer: The 2nd International Conference on the Ambulatory Monitoring of Physical Activity and Movement 2011
  • Place of Presentation: Glasgow, United Kingdom
  • Year and Date: 20110524-27
• [Presentation] Effects of enteric-coated lactoferrin supplementation on the immune status of healthy elderly individuals : a randomized, double-blind, placebo -controlled trial (2011)
  • Author(s): Kawakami H, Park H, Park S, Kuwata H, and Aoyagi Y
  • Organizer: The 10th International Conference on Lactoferrin : Structure, Function, and Application
  • Place of Presentation: Mazatlan, Mexico
  • Year and Date: 20110508-12
• [Book] あらゆる病気を防ぐ「一日8000歩・速歩き20分」健康法 (2013)
  • Author(s): 青柳幸利
  • Publisher: 東京 : 草思社
• [Book] 「中之条研究」の基礎となった, 高齢者における歩行機能の重要性 : 老化のメカニズムと予防法 (2012)
  • Author(s): 青柳幸利. 背景編
  • Publisher: 東京 : ノーブル・プレス
• [Book] 「中之条研究」で実証された, 健康長寿の実現に最適な日常身体活動の量と質 (2011)
  • Author(s): 青柳幸利. 基礎編
  • Publisher: 東京 : ノーブル・プレス
• [Book] 「中之条研究」で実証された, 医療費削減の効果が得られる日常身体活動の量と質 (2011)
  • Author(s): 青柳幸利. 実践編
  • Publisher: 東京 : ノーブル・プレス
• [Book] Health-related quality of life and habitual physical activity among older Japanese. In A.C. Michalos (Ed.), Encyclopedia of quality of life research
  • Author(s): Aoyagi Y., Shephard R.J
  • Publisher: Heidelberg: Springer(In press)