2013 Fiscal Year Final Research Report
Analysis of the mechanisms of phosphorus homeostasis in major organ using high-phosphorus diet administrated rat model and its application
| Project/Area Number |
23300273
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NAKAI Yuji 東京大学, 農学生命科学研究科, 特任准教授(移行) (10321788)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIJIMA Tomoko 東京大学, 大学院・農学生命科学研究科, 特任助教 (80568270)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 高リン食 / DNAマイクロアレイ / ラット / 腎臓 / 肝臓 / 白色脂肪組織 / NaPi-IIb |
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| Research Abstract |
Ten male Wistar rats were divided into two groups and fed a diet containing 0.3% (C) or 1.2% (HP) phosphorous for 24 days. DNA microarray analyses were performed using kidney, liver and white adipose tissue (WAT) of these animals. A hierarchical clustering analysis revealed that gene expression profiles of the two groups are different from each other. Among the genes that were differentially expressed between the two groups, there was significant upregulation of type IIb sodium-dependent phosphate transporter (NaPi-IIb) in the kidney of HP rats. As for the liver, upregulation of fatty acid beta-oxidation and downregulation of amino acid catabolic process by HP diet administration were observed. Upregulation of genes related to fatty acid beta-oxidation was also observed in the WAT of HP rat. Thus, our results indicate that administration of high phosphorus diet induced not only regulation of phosphate homeostasis but also changes in various metabolic pathways.
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[Journal Article] Influence of a Short-Term Iron-Deficient Diet on Hepatic Gene Expression Profiles in Rats2013
Author(s)
Kamei, A., Watanabe, Y., Kondo, K., Okada, S., Shinozaki, F., Ishijima, T., Nakai, Y., Kondo, T., Arai, S., and Abe, K
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Journal Title
PLoS ONE
Volume: 8
Pages: e65732
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[Journal Article] High Phosphorus Diet-Induced Changes in NaPi-IIb Phosphate Transporter Expression in the Rat Kidney : DNA Microarray Analysis2012
Author(s)
Suyama, T., Okada, S., Ishijima, T., Iida, K., Abe, K., and Nakai, Y
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Journal Title
PLoS ONE
Volume: 7
Pages: e29483
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