2013 Fiscal Year Final Research Report
Exploration and exploit of intratumor microenvironment for both controlling local tumors and reducing distant metastatic potential
| Project/Area Number |
23300348
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAGASAWA Hideko 岐阜薬科大学, 薬学部, 教授 (90207994)
TANO Keizo 京都大学, 原子炉実験所, 准教授 (00183468)
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| Project Period (FY) |
2011-11-18 – 2014-03-31
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| Keywords | 休止期腫瘍細胞 / 急性低酸素 / 慢性低酸素 / 酸素化休止期腫瘍細胞 / 癌幹細胞 / 中性子捕捉療法 / CBE値 / 腫瘍血管正常化現象 |
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| Research Abstract |
Based on the developed method both for detecting the potential for controlling local tumors including intratumor quiescent cells and for evaluating pulmonary distant metastases from local tumors, releasing intratumor acute hypoxia leads to reduction of pulmonary metastatic potential, and boron neutron capture therapy with BSH (sodium borocaptate-10B) and with BPA (L-para-boronophenylalanin-10B) result in increasing the potential for controlling local tumors and suppressing the pulmonary distant metastatic potential, respectively.
Intratumor oxic quiescent cells were shown to have a greater recovery capacity like cancer stem cells, but not hypoxic, through selectively detecting their radio-sensitivity.
The compound biological effectiveness values for neutron capture agents that deliver into solid tumors more dependently on uptake capacity of tumor cells became more changeable. The value may be one of the indices showing the degree of tumor heterogeneity.
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Research Products
(43 results)
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[Journal Article] Boron neutron capture therapy outcomes for advanced or recurrent head and neck cancer2014
Author(s)
Suzuki M, Kato I, Aihara T, Hiratsuka J, Yoshimura K, Niimi M, Kimura Y, Ariyoshi Y, Haginomori S, Sakurai Y, Kinashi Y, Masunaga S, et al, 計15名
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Journal Title
J Radiat Res
Volume: 55(1)
Pages: 146-153
DOI
Peer Reviewed
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[Journal Article] Pilot clinical study of boron neutron capture therapy for recurrent hepatic cancer involving the intra-arterial injection of a ^<10>BSH-containing WOW emulsion2014
Author(s)
Yanagie H, Higashi S, Seguchi K, Ikushima I, Fujihara M, Nonaka Y, Oyama K, Maruyama S, Hatae R, Suzuki M, Masunaga S, et al. 計23名
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Journal Title
Appl Radiat Isot
Pages: S0969-8043(14)00021-9
DOI
Peer Reviewed
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[Journal Article] Evaluation of SCCVII tumor cell survival in clamped and non-clamped solid tumors exposed to carbon-ion beams in comparison to X-rays2013
Author(s)
Hirayama R, Uzawa A, Takase N, Matsumoto Y, Noguchi M, Koda K, Ozaki M, Yamashita K, Li H, Kase Y, Matsufuji N, Koike S, Masunaga S, et al. 計16名
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Journal Title
Mutat Res
Volume: 756(1-2)
Pages: 146-151
DOI
Peer Reviewed
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[Journal Article] Evaluation of In vivo Radiosensitizing Activity of Etanidazole as Hypoxic Radiosensitizer Using Tumor-bearing Chick Embryo2011
Author(s)
Abe C, Uto Y, Nakae T, Shinmoto Y, Sano K, Nakata H, Teraoka M, Endo Y, Maezawa H, Masunaga S, et al. 計12名
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Journal Title
J Radiat Res
Volume: 52(2)
Pages: 208-214
DOI
Peer Reviewed
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[Presentation] Evaluation of cell survival and micronucleus formation in clamped and non-clamped solid tumors exposed to carbon-ion beams in comparison to X-rays2012
Author(s)
Hirayama R, Uzawa A, Takase N, Koda K, Matsumoto Y, Ozaki M, Noguchi M, Kase Y, Matsufuji N, Koike S, Masunaga S, Ando K, Okayasu R, Furusawa Y
Organizer
At the 10th International Symposium on Chromosomal Aberrations
Place of Presentation
Amalfi, Italy
Year and Date
20121019-21
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