Realizing the induction heating cancer therapy by developing new iron nano particle and combination of tumor penetrating peptide (iRGD).

2014 Fiscal Year Final Research Report

• Project/Area Number: 23300362
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Clinical oncology
• Research Institution: University of Tsukuba
• Principal Investigator: ODA Tatsuya 筑波大学, 医学医療系, 教授 (20282353)
• Co-Investigator(Kenkyū-buntansha): YANAGIHARA Hideto 筑波大学, 数理物質系, 准教授 (50302386)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 電磁誘導加熱 / 癌焼灼治療 / 磁性ナノ粒子

Outline of Final Research Achievements

The present research aimed to realize the induction heating cancer therapy, that involve delivers magnetic nano-particles to cancer nodules and eradicate cancer by heat using irradiation of alternating current magnetic field. For this purpose, iron nano particle with high heat productive power more than 500 W/g was indispensable, which was not available at the project start time, and we originally developed surface-modified iron nanoparticle (DINP). The successful production of this new iron nanoparticle were subjected to application of international patent. The surface modification of DINP by block-polymer PEG did not confer sufficient stealth effect which aimed to escape from capture by macrophage and Kupffer cells. The enhanced delivery of DINP by co-addministration of tumor specific penetrating peptide (iRGD) were also unsuccessful. Instead, we directly injected DINP into mouse xenograft and obtained complete eradication by induction heating.

Free Research Field

消化器外科学