Characterization of nuclear pore complex re-assembly dynamics in cell cycle

2014 Fiscal Year Final Research Report

• Project/Area Number: 23310151
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Living organism molecular science
• Research Institution: Kanazawa University
• Principal Investigator: WONG W・Richard 金沢大学, 自然システム学系, 教授 (30464035)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 核膜孔複合体 / 細胞周期 / オートファジー / Tpr / Nup62 / Nup358 / 中心体 / ｐ５３

Outline of Final Research Achievements

The nuclear pore complex (NPC) is the major gatekeeper of macromolecular traffic between the nucleus and cytoplasm. It is composed of multiple subunits comprising ≈30 proteins called nucleoporins. During cell division, transmembrane nucleoporins and nuclear envelope membrane fragments move to the endoplasmic reticulum, while other nucleoporins are disassembled into subcomplexes that are distributed throughout the mitotic cytoplasm to kinetochore, spindle and centrosome regions. In this project, we are investigating the association of NPC proteins assembly and disassembly during cell division. We constantly published peer-reviewed papers with impact factor 5 and our graduate students all received awards in the society or conferences.

Free Research Field

複合新領域