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2013 Fiscal Year Final Research Report

a

Research Project

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Project/Area Number 23350060
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional materials chemistry
Research InstitutionKanagawa University

Principal Investigator

SUGAWARA Tadashi  神奈川大学, 理学部, 教授 (50124219)

Co-Investigator(Kenkyū-buntansha) 高倉 克人  鈴鹿工業高等専門学校, 准教授 (60396843)
Project Period (FY) 2011-04-01 – 2014-03-31
Keywords膜・集合体 / ベシクル
Research Abstract

1) Linkage between self-replication of DNA and self-reproduction of giant vesicles (GVs) was revealed on the basis of observation by optical microscopy and the populational analysis of groups of GVs. Although daughter GVs produced from the mother GV, were depleted with dNTP (deoxyNucleoside TriPhosphate), they adhered conveyer GVs filled with dNTP and fused with each other under the acidic condition. Hence daughter GVs acquired recursive ability; they were able to self-replicate DNA and self-divided after addition of the precursor of a membrane lipid. They also gave birth to granddaughters according to the same procedure. 3) It was found that this self-reproduction cycle consisted of four stages (Ingestion, Replication, Maturity, and Division), and each stage was promoted to the next by events which occurred in GVs.

  • Research Products

    (39 results)

All 2014 2013 2012 2011 Other

All Journal Article (13 results) Presentation (19 results) (of which Invited: 19 results) Book (5 results) Remarks (2 results)

  • [Journal Article] Spontaneous transformation from micelles to vesicles associated with sequential conversions of comprising amphiphiles within assemblies2014

    • Author(s)
      K. Takakura, T. Yamamoto, K. Kurihara, T. Toyota, K. Ohnuma and T. Sugawara
    • Journal Title

      Chem. Commun.

      Volume: 50 Pages: 2190-2192

    • DOI

      10.1039/C3CC43488E

  • [Journal Article] Chemical Control of the Monovalent-Divalent Electron-Transfer Phase Transition in Biferrocenium-TCNQ Salts2014

    • Author(s)
      T. Mochida, Y. Funasako, K. Takazawa, M. Takahashi, M. M. Matsushita, T. Sugawara
    • Journal Title

      Chem Commun.

      Volume: 50 Pages: 5473-5475

    • DOI

      10.1039/c4cc01296h

  • [Journal Article] 分子システムとしてつくる人工細胞2014

    • Author(s)
      菅原正, 鈴木健太郎, 栗原謙輔, 豊田太郎
    • Journal Title

      豊田研究報告

      Volume: 67 Pages: 63-70

  • [Journal Article] 自らが増殖する人工細胞の化学構築2014

    • Author(s)
      菅原正, 鈴木健太郎
    • Journal Title

      高分子

      Volume: 6 月号, No.6 Pages: 382-384

  • [Journal Article] Bi-axial alignment control of guanine crystals by diamagnetic orientation2013

    • Author(s)
      M. Iwasaka, Y. Miyashita, Y. Mizukawa, K. Suzuki, T. Toyota, T. Sugawara
    • Journal Title

      Appl. Phys. Exp

      Volume: 6 Pages: 037002-1-4

    • DOI

      10.7567/APEX.6.037002

  • [Journal Article] Macroscopic motion of supramolecular assemblies actuated by photoisomerization of azobenzene derivatives2013

    • Author(s)
      Y. Kageyama, N. Tanigake, Y. Kurokome, S. Iwaki, S. Takeda, K. Suzuki and T. Sugawara
    • Journal Title

      Chem. Commun.

      Volume: 49 Pages: 9386-9388

    • DOI

      10.1039/C3CC47786J

  • [Journal Article] Adhesion and Fusion of Two Kinds of Phospholipid Hybrid Vesicles Controlled by Surface Charges of Vesicular Membranes2012

    • Author(s)
      K. Suzuki, R. Aboshi, K. Kurihara, T. Sugawara
    • Journal Title

      Chem. Lett

      Volume: 41 Pages: 789-791

    • DOI

      10.1246/cl2012.789

  • [Journal Article] pH-Induced Switchable Vesicular Aggregation of Zwitterionic Phospholipids and Anionic Phospholipids2012

    • Author(s)
      K. Suzuki, K. Kurihara, Y. Okura, T. Toyota, T. Sugawara
    • Journal Title

      Chem. Lett

      Volume: 41 Pages: 1084-1086

    • DOI

      10.1246/cl2012.1084

  • [Journal Article] Local electronic properties at organic-metal interfaces : thiophene derivatives on Pt (III)2012

    • Author(s)
      H. Sato, S. Ushiyama, M. Sogo, M. Aoki, K. Shudo, T. Sugawara, S. Yanagisawa, Y. Morikawa, S.Masuda
    • Journal Title

      Phys. Chem. Chem. Phys

      Volume: 14 Pages: 15412-15420

  • [Journal Article] 人工細胞(原始細胞モデル)との化学的構築2012

    • Author(s)
      庄田耕一郎, 栗原謙輔, 菅原正
    • Journal Title

      遺伝 : 生物の科学

      Volume: 66 , No4 Pages: 365-373

  • [Journal Article] Compartment size dependence of performance of polymerase chain reaction inside giant vesicles2011

    • Author(s)
      K. Shohda, M. Tamura, Y. Kageyama, K. Suzuki, A. Suyama, T. Sugawara
    • Journal Title

      Soft Matter

      Volume: 7 Pages: 3750-3753

    • DOI

      10.1039/C0SM01463J

  • [Journal Article] Multitude of Morphological Dynamics of Giant Multilamellar Vesicles in Regulated Nonequilibrium Environments2011

    • Author(s)
      T. Tomita, T. Sugawara, Y. Wakamoto
    • Journal Title

      Langmuire

      Volume: 27 Pages: 10106-10112

    • DOI

      10.1021/la2018456

  • [Journal Article] Self-reproduction of supramolecular giant vesicles combined with the amplification of encapsulated DNA2011

    • Author(s)
      K. Kurihara, M. Tamura, K. Shohda, T. Toyota, K. Suzuki, T. Sugawara
    • Journal Title

      Nature Chemistry

      Volume: 3 Pages: 775-781

    • DOI

      10.1038/nchem.1127

  • [Presentation] Emergence of Active Site for Self-reproducing Dyanmics in Vesicle-based Protocell2014

    • Author(s)
      T. Sugawara
    • Organizer
      The 2nd In teranational Symposium on Dyanmical Ordering of Biomolecular Systems for Creation of Intergerated Functions
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      20140111-12
    • Invited
  • [Presentation] Artificial Cell Constructed as a Molecular System2013

    • Author(s)
      T. Sugawara
    • Organizer
      第7回分子科学討論会
    • Place of Presentation
      京都テルサ
    • Year and Date
      20130924-27
    • Invited
  • [Presentation] Approach to Evolvable Protocell2013

    • Author(s)
      T. Sugawara
    • Organizer
      International Workshop "From Soft Matter to protocell"
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      20130918-20
    • Invited
  • [Presentation] Artificial Cell Viewed as a Molecular System2013

    • Author(s)
      T. Sugawara
    • Organizer
      Okazaki Institute for Integrative Bioscience, Summer School 2013 "Bioorganization"
    • Place of Presentation
      Okazaki, Japan
    • Year and Date
      20130822-24
    • Invited
  • [Presentation] 外的刺激により繰り返し自己増殖するベシクル型人工細胞2013

    • Author(s)
      菅原正
    • Organizer
      第2回NINS Colloquium自然科学の将来像セッション3新物質と新機能-インテリジェントマテリアル-
    • Year and Date
      2013-12-16
    • Invited
  • [Presentation] 分子システムとしての人工細胞2013

    • Author(s)
      菅原正
    • Organizer
      公益財団法人豊田理化学研究所第13回フェロー研究報告会
    • Year and Date
      2013-12-11
    • Invited
  • [Presentation] 分子システムとしてみた人工細胞2013

    • Author(s)
      菅原正
    • Organizer
      第4回CIMoS(Research Center of Integrative Molecular Systems : 分子科学研究所)セミ ナー
    • Year and Date
      2013-07-22
    • Invited
  • [Presentation] Vesicular transport of depleted ingredients to a self-reproduced model protocell2012

    • Author(s)
      T. Sugawara, K. Kuriharara, T. Toyota, K. Suzuki
    • Organizer
      International Association of Colloid and Interface Scientists, Conference (IACIS2012)
    • Place of Presentation
      Sendai
    • Year and Date
      20120513-18
    • Invited
  • [Presentation] Giant Vesicle-based Sustainable Ptotocell2012

    • Author(s)
      T. Sugawara
    • Organizer
      2012 Exchange Symposium for Kanagawa University -National Taiwan University
    • Place of Presentation
      National Taiwan University, Taipei
    • Year and Date
      2012-12-29
    • Invited
  • [Presentation] セッション「自己組織化と生命 : 分子と生命をつなぐ架け橋(Self-organization in life: the essence to build up life from molecules)」 "Sustainable Model of Giant Vesicle-based Protocell"2012

    • Author(s)
      菅原正
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      Fukuoka
    • Year and Date
      2012-12-14
    • Invited
  • [Presentation] Proposal of an Evolvable Protocell2012

    • Author(s)
      T. Sugawara, et al.
    • Organizer
      2nd Discussion Symposium on Artificial Life and Biomimetic Functional Materials
    • Place of Presentation
      Sapporo
    • Year and Date
      2012-12-11
    • Invited
  • [Presentation] 分子システムとしてみた生体機能-自己複製,自己生産,自律運動-2012

    • Author(s)
      菅原正
    • Organizer
      第23回基礎有機化学討論会
    • Place of Presentation
      京都コルサ
    • Year and Date
      2012-09-21
    • Invited
  • [Presentation] 構成的アプローチによる生命システムの再構築2012

    • Author(s)
      菅原正
    • Organizer
      第123回東北大学金属材料研究所講演会
    • Place of Presentation
      東北大学金属材料研究所
    • Year and Date
      2012-05-23
    • Invited
  • [Presentation] Manipulating Molecular Electronics Composed of Redox of Redox-active π-systems2011

    • Organizer
      The 11th European Conference of Molecular Electronics (ECME 2011)
    • Year and Date
      20110907-10
    • Invited
  • [Presentation] Plenary Lecture "Cross - π - conjugated TTF-based Donor Radical as a Building Block of Molecular Spintronics2011

    • Organizer
      14th International Symposium on Novel Aromatic Compounds (ISNA-14)
    • Year and Date
      20110724-29
    • Invited
  • [Presentation] Self-Reproduction of Giant Vesicle Combined with Amplification of Encapsulated DNA2011

    • Organizer
      International Conference"Engineering of Chemical Complexity" Mini-symposium 6 : "Nonequilibrium soft matter"
    • Place of Presentation
      Harnack House, Berlin
    • Year and Date
      20110704-08
    • Invited
  • [Presentation] 「脂質生化学の新展開‐脂質機能に迫る新しい構成論的アプローチ‐」ベシクル型人工細胞への構成的アプローチ2011

    • Author(s)
      菅原正
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2011-09-24
    • Invited
  • [Presentation] Inorganic Biology and Protocells : Engineergin Artifficial Life2011

    • Organizer
      Symposium on "Inorganic Biology and Protocells : Engineergin Artifficial Life"
    • Place of Presentation
      University of Glasgow
    • Year and Date
      2011-09-13
    • Invited
  • [Presentation] Chemical Approach Towards a Protcell Model2011

    • Organizer
      Special Seminar
    • Place of Presentation
      Minnesota University, Minneapolis
    • Year and Date
      2011-07-29
    • Invited
  • [Book] 超分子の化学2014

    • Author(s)
      菅原正, 木村榮一編
    • Total Pages
      211
    • Publisher
      裳華房
  • [Book] 現代化学2013

    • Author(s)
      濱田嘉昭, 菅原正
    • Total Pages
      293
    • Publisher
      NHK出版
  • [Book] World Scientific, Constructive Approach Towards Protocells in Engineering of Chemical Complexity World Scientiffc Lecture Notes in Complex Systems(Eds, A.S. Mikhailov, G.Ertl)2013

    • Author(s)
      T. Sugawara, K.Kurihara, K,Suzuki
    • Total Pages
      359-374
  • [Book] "Magnetism Conductivity" in Multifunctional Molecu1ar Materials2013

    • Author(s)
      T .Sugawara, A. Miyazaki
    • Total Pages
      160
    • Publisher
      Pan Stanford Pub
  • [Book] 実験医学増刊 : 細胞を創る・生命システムを創る,第1章1「生体膜モデルから増殖型人工細胞へ-膜分子設計からのアプローチ」2011

    • Author(s)
      菅原正, 他
    • Total Pages
      26-40
    • Publisher
      羊土社
  • [Remarks] 神奈川大学理学部化学科の教員紹介

    • URL

      http://www.chem.kanagawa-u.ac.jp/detail//id213/html

  • [Remarks] 東京大学大学院複雑系生命システムセンター

    • URL

      http://rcis.c.u-tokyo.ac.jp/index.html

URL: 

Published: 2015-06-25  

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