2013 Fiscal Year Final Research Report
Research on signal transduction via transcriptional mediators
| Project/Area Number |
23370079
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
ISHII Shunsuke 独立行政法人理化学研究所, 石井分子遺伝学研究室, 上席研究員 (00124785)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 転写メディエーター / シグナル伝達 |
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| Research Abstract |
We found that corepressor Ski binds to TRIM27, and that TRIM27 contributes to deubiquitination via forming a complex with USP7. It was found that TRIM27 enters into the nucleus in response to poly(I-C) stimulation, suggesting that Ski ubiquitination may be regulated by TRIM27 in response to specific signaling.
In knockout mice of transcriptional adaptor Shn-2, T cell differentiation in thymus is blocked. It was found that Shn-2 is modified by O-GlcNAc at several sites which modulates nuclear entry of Shn-2. It was demonstrated that Shn-2 is localized on the T-cell receptor beta gene locus, and modulated allelic exclusion.
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[Journal Article] Histone variants enriched in oocytes enhance reprogramming to induced pluripotent stem cells2014
Author(s)
Shinagawa T, Takagi T, Tsukamoto D, Tomaru C, Huynh LM, Sivaraman P, Kumarevel T, Inoue K, Nakato R, Katou Y, Sado T, Takahashi S, Ogura A, Shirahige K & Ishii S
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Journal Title
Cell Stem Cell
Volume: 14
Pages: 217-227
DOI
Peer Reviewed
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[Journal Article] Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia2013
Author(s)
Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura HK, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton NM, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S & Miyakawa T
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Journal Title
Neuropsychopharmacology
Volume: 38
Pages: 1409-1425
DOI
Peer Reviewed
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[Journal Article] Schnurri-2 deficiency counteracts against bone loss induced by ovariectomy2011
Author(s)
Nagao M, Saita Y, Hanyu R, Hemmi H, Notomi T, Hayata T, Nakamoto T, Kaneko K, Kurosawa H, Ishii S, Ezura Y & Noda M
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Journal Title
J Cell Physiol
Volume: 226
Pages: 573-578
DOI
Peer Reviewed
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[Presentation] Deficiency of Schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia2012
Author(s)
宮川剛, 高雄啓三, 萩原英雄, 大平耕司, 昌子浩孝, 服部聡子, 小清水久嗣, 梅森十三, 高木豪, 石井俊輔
Organizer
第35回日本分子生物学会年会
Place of Presentation
福岡
Year and Date
2012-12-12
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