Development of systemically injectable siRNA delivery systems by fine-tuning of block copolymers

2014 Fiscal Year Final Research Report

• Project/Area Number: 23390009
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Tokyo Institute of Technology (2012-2014); The University of Tokyo (2011)
• Principal Investigator: NISHIYAMA Nobuhiro 東京工業大学, 資源化学研究所, 教授 (10372385)
• Co-Investigator(Kenkyū-buntansha): MIYATA Kanjiro 東京大学, 大学院医学系研究所, 准教授 (50436523)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: siRNA / DDS / ブロック共重合体 / ポリエチレングリコール(PEG) / ポリ(L-リジン)(PLL) / がん / 腎疾患

Outline of Final Research Achievements

siRNA is expected to be used for the treatment of various diseases due to its capability to efficiently knockdown the target mRNA in a sequence-specific manner. However, the development of useful vehicles for siRNA is a critical issue. We have recently found that poly(ethylene glycol)-polycations block copolymers can form small-sized polyion complexes with single molecule siRNA, and in this study, we have studied the utility of small-sized polyion complexes named “PIC nanocarriers” as siRNA delivery systems. The optimized PIC nanocarriers exhibited prolonged circulation and enhanced tumor accumulation after the systemic administration. We have demonstrated the usefulness of PIC nanocarriers for the treatment of solid tumors and kidney diseases.

Free Research Field

バイオマテリアル、ドラッグデリバリーシステム