2013 Fiscal Year Final Research Report
Food entrainable circadian rhythm in humans
| Project/Area Number |
23390047
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
NISHIDE Shin-ya 北海道大学, 大学院・医学研究科, 助教 (40451398)
YAMANAKA Yujiro 北海道大学, 大学院・医学研究科, 助教 (20528343)
HASHIMOTO Satoko 北海道大学, 大学院・医学研究科, 学術研究員 (80374247)
|
|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Keywords | 生物時計 / 食事 / 生体リズム / コルチゾール / 睡眠 |
|---|
| Research Abstract |
Appearance of premeal anticipatory hormone peak and entrainability of restricted meal schedule were examined in humans who stayed in a temporal isolation facility without knowing the time of day. Meal was supplied once a day for 10 days. As a result, the premeal peak was not detected in plasma melatonin, cortisol, insulin, ghrelin, and leptin. On the other hand, the sleep-wake cycle was entrained by the meal schedule, whereas the circadian melatonin rhythm was not entrained showing phase-delay shifts. These findings indicated that the so-called food entrainable circadian rhythm failed to appear in humans under the present conditions, and that the meal schedule was the time cue for the sleep-wake cycle but not for the circadian pacemaker.
|
Research Products
(30 results)
