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2013 Fiscal Year Final Research Report

Effects of insulin resistance-related factors on the stem cell functions in vivo.

Research Project

  • PDF
Project/Area Number 23390056
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General pharmacology
Research InstitutionShiga University of Medical Science

Principal Investigator

IMAMURA Takeshi  滋賀医科大学, 医学部, 准教授 (00552093)

Co-Investigator(Kenkyū-buntansha) TORII Ryuzou  滋賀医科大学, 動物生命科学研究センター, 教授 (50106647)
Co-Investigator(Renkei-kenkyūsha) YOSHIDA Yoshinori  京都大学, iPS 細胞研究所, 講師 (20447965)
OKAMURA Tomio  滋賀医科大学, 医学部, 教授 (70152337)
TAWA Masashi  滋賀医科大学, 医学部, 助教 (10510274)
Project Period (FY) 2011-04-01 – 2014-03-31
Keywords幹細胞 / インスリン抵抗性因子 / 糖尿病
Research Abstract

In this study, we planned to investigate whether the stem cell functions are damaged under the diabetic and/or insulin resistant conditions. Using the iPS cells established with the skin fibroblast of cynomolgus monkey, we identified the inhibitory effects of insulin resistant factor, IL-1beta on the ability of differentiation from iPS cells in vitro and in vivo. Thus, it is suggested that the stem cell functions are modified by the insulin resistant factors.

  • Research Products

    (13 results)

All 2014 2013 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Effects of atorvastatin, amlodipine, and their combination on vascular dysfunction in insulin-resistant rats2014

    • Author(s)
      Okamura T, Tawa M, Geddawy A, Shimosato T, Iwasaki H, Shintaku H, Yoshida Y, Masada M, Shinozaki K, Imamura T
    • Journal Title

      J Pharmacol Sci

      Volume: 124 Pages: 76-85

    • URL

      https://www.jstage.jst.go.jp/article/jphs/124/1/124_13178FP/_article

    • Peer Reviewed
  • [Journal Article] The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR432013

    • Author(s)
      Kimura I, Ozawa K, Inoue D, Imamura T, Kimura K, Maeda T, Terasawa K, Kashihara D, Hirano K, Tani T, Takahashi T, Miyauchi S, Shioi G, Inoue H, Tsujimoto G
    • Journal Title

      Nature Commun

      Volume: 4 Pages: 1829-1840

    • DOI

      10.1038/ncomms2852

    • Peer Reviewed
  • [Journal Article] Influence of hypoxia on endothelium-derived NO-mediated relaxation in rat carotid, mesenteric and iliac arteries2013

    • Author(s)
      Tawa M, Shimosato T, Geddawy A, Imamura T, Okamura T
    • Journal Title

      Pharmacology

      Volume: 91 Pages: 322-30

    • DOI

      10.1159/000351706

    • Peer Reviewed
  • [Journal Article] Chronic Administration of Nicotine-Free Cigarette Smoke Extract Impaired Endothelium-Dependent Vascular Relaxation in Rats via Increased Vascular Oxidative Stress2012

    • Author(s)
      Shimosato T, Geddawy A, Tawa M, Imamura T, Okamura T
    • Journal Title

      J Pharmacol Sci

      Volume: 118 Pages: 206-214

    • URL

      https://www.jstage.jst.go.jp/article/jphs/118/2/118_11187FP/_article

    • Peer Reviewed
  • [Journal Article] Contribution of nitric oxide in big endothelin-1-induced cardioprotective effects on ischemia/ reperfusion injury in rat hearts2011

    • Author(s)
      Tawa M, Fukumoto T, Ohkita M, Yamashita N, Geddawy A, Imamura T, Ayajiki K, Okamura T, Matsumura Y
    • Journal Title

      J Cardiovasc Pharmacol

      Volume: 57 Pages: 575-578

    • DOI

      10.1097/FJC.0b013e31821325ad

    • Peer Reviewed
  • [Journal Article] Impairment by hypoxia or hypoxia/reoxygenation of nitric oxide-mediated relaxation in isolated monkey coronary artery : the role of intracellular superoxide2011

    • Author(s)
      Tawa M, Yamamizu K, Geddawy A, Shimosato T, Imamura T, Ayajiki K, Okamura T
    • Journal Title

      J Pharmacol Sci

      Volume: 116 Pages: 188-196

    • URL

      https://www.jstage.jst.go.jp/article/jphs/116/2/116_11031FP/_article

    • Peer Reviewed
  • [Presentation] Glycogen Synthase Kinase-3 beta differentially modifies early and late stages of adipogenesis from the pluripotent stem cells to mature adipocytes2014

    • Author(s)
      今村武史
    • Organizer
      第87回日本薬理学会総会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2014-03-20
  • [Presentation] Effects of diabetic conditions on the stem cell functions transplanted in diabetic monkeys2014

    • Author(s)
      今村武史
    • Organizer
      キーストン・シンポジウム
    • Place of Presentation
      Keystone 米国 コロラド州
    • Year and Date
      2014-01-14
  • [Presentation] インスリン抵抗性ラットにおける血管機能障害に及ぼすアトロバスタチンおよびアムロジピンの併用効果2013

    • Author(s)
      田和正志
    • Organizer
      第13回日本NO 学会学術集会
    • Place of Presentation
      沖縄県医師会館
    • Year and Date
      2013-06-28
  • [Presentation] Effects of insulin resistance on adipogenic differentiation of the stem cells transplanted in cynomolgus monkeys2013

    • Author(s)
      今村武史
    • Organizer
      第86回日本薬理学会総会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2013-03-22
  • [Presentation] Inhibition of Glycogen Synthase Kinase-3 beta enhances adipogenesis via the stimulation of glucose transport in mesenchymal stem cells2013

    • Author(s)
      今村武史
    • Organizer
      キーストン・シンポジウム
    • Place of Presentation
      Keystone 米国 コロラド州
    • Year and Date
      2013-02-26
  • [Presentation] Activity of fat cell differentiation in diabetic conditions2012

    • Author(s)
      今村武史
    • Organizer
      第85回日本薬理学会総会
    • Place of Presentation
      国立京都国際会議場
    • Year and Date
      2012-03-16
  • [Remarks]

    • URL

      http://www.shiga-med.ac.jp/pharm/research.html

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Published: 2015-06-25  

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