2013 Fiscal Year Final Research Report
Analysis of signal transduction pathways evoked by virus infection
Project/Area Number |
23390090
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Experimental pathology
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Research Institution | Hokkaido University |
Principal Investigator |
OHBA Yusuke 北海道大学, 医学(系)研究科(研究院), 教授 (30333503)
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Co-Investigator(Renkei-kenkyūsha) |
TSUDA Masumi 北海道大学, 大学院・医学研究科, 助教 (30431307)
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Project Period (FY) |
2011-04-01 – 2014-03-31
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Keywords | シグナル伝達 / エンドサイトーシス / バイオイメージング / インフルエンザウイルス |
Research Abstract |
Virus infections are one of the largest threats of humanity in modern society with scientific and technological advances, of which the H1N1 pandemic in 2009 would be a practical example. We have previously reported that PI3K bound to and activated by Ras plays a crucial role in the regulation of endocytosis by deciphering the signal transduction pathways with the best use of fluorescence bioimaging techniques. In this study, we found that Ras-PI3K signaling is required for influenza virus infection, and identified intracellular calcium as a key molecule to regulate a series of influenza virus infection processes. It might also be expected to lead to a new concept of antivirus therapeutics through application of these results.
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Research Products
(43 results)
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[Journal Article] Sustained elevation of Snail promotes Glial- Mesenchymal Transition (GMT) after irradiation in malignant glioma2014
Author(s)
R. Mahabir, M, Tanino, E. Aiman, L. Wang, T. Kimura, T. Itoh, Y. Ohba, H. Nishihara, H. Shirato, M. Tsuda, and S. Tanaka
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Journal Title
Neuro-Oncology
Volume: 6
Pages: 671-685
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[Journal Article] Beneficial innate signaling 4/5 interference for anti-bacterial responses by a TLR-mediated enhancement of the MKP-IRF3 axis2013
Author(s)
H. Negishi, K. Matsuki, N. Endo, H. Sarashina, S. Miki, A. Matsuda, K. Fukazawa, N. Taguchi-Atarashi, H. Ikushima, H. Yanai, J. Nishio, K. Honda, Y. Fujioka, Y. Ohba, T. Noda, S. Taniguchi, E. Nishida, Y. Zhang, H. Chi, R. A. Flavell, and T. Taniguchi
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Journal Title
Proc. Natl. Acad. Sci. U.S.A.
Volume: 110
Pages: 19884-19889
DOI
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[Journal Article] Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB12012
Author(s)
S. Chiba, M. Baghdadi, H. Akiba, H. Yoshiyama, I. Kinoshita, H. Dosaka-Akita, Y. Fujioka, Y. Ohba, J.V. Gorman, J.D. Colgan, M. Hirashima, T. Uede, A. Takaoka, H. Yagita and M. Jinushi
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Journal Title
Nat. Immunol
Volume: 13
Pages: 832-842
DOI
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[Journal Article] DJ-1 associates with synaptic membranes2011
Author(s)
Y. Usami, T. Hatano, S. Imai, S.I. Kubo, S. Sato, S. Saiki, Y. Fujioka, Y. Ohba, F. Sato, M. Funayama, H. Eguchi, K. Shiba, H. Ariga, J. Shen and N. Hattori
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Journal Title
Neurobiol. Dis
Volume: 43
Pages: 651-662
DOI
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[Journal Article] Induction of colonic regulatory T cells by indigenous Clostridium species2011
Author(s)
K. Atarashi, T. Tanoue, T. Shima, A. Imaoka, T. Kuwahara, Y. Momose, G. Cheng, S. Yamasaki, T. Saito, Y. Ohba, T. Taniguchi, K. Takeda, S. Hori, I.I. Ivanov, Y. Umesaki, K. Itoh and K. Honda
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Journal Title
Science
Volume: 331
Pages: 337-341
DOI
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[Journal Article] ZAPS is a potent stimulator of RIG-I-mediated signaling for antiviral response2011
Author(s)
S. Hayakawa, S. Shiratori, H. Yamato, T. Kameyama, C. Kitatsuji, F. Kashigi, S. Goto, S. Kameoka, D. Fujikura, T. Yamada, T. Mizutani, M. Kazumata, M. Sato, J. Tanaka, M. Asaka, Y. Ohba, T. Miyazaki, M. Imamura and A. Takaoka
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Journal Title
Nat. Immunol
Volume: 12
Pages: 37-44
DOI
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