2013 Fiscal Year Final Research Report
The role of CD169 macrophages in anti-tumor immunity induced by dead tumor cells
| Project/Area Number |
23390095
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
TANAKA Masato 東京薬科大学, 生命科学部, 教授 (00294059)
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| Co-Investigator(Renkei-kenkyūsha) |
ASANO Kenichi 東京薬科大学, 生命科学部, 准教授 (10513400)
NISHITAI Gen 東京薬科大学, 生命科学部, 助教 (60509941)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | がん / マクロファージ / 細胞死 |
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| Research Abstract |
In this study, we tried to reveal the molecular and cellular mechanisms of activation of anti-tumor immunity by CD169-positive macrophages located in lymph node sinus. We generated CD169-Cre-YFP mice, in which CD169-positive macrophages were specifically labeled with YFP, and examined the character of these cells using the mice. We also identified CD169 macrophages-producing molecules that may be able to activate anti-tumor immunity. We established an experimental model to induce cell death of tumor cells in tumor-bearing mice, found the drastic changes in tumor-associated macrophages after tumor cell death. We also reveal the roles of CD169 macrophages in the immune regulation in non-immune tissues.
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