2013 Fiscal Year Final Research Report
Molecular Basis of differentiation of Entamoeba histolytica
| Project/Area Number |
23390099
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUKUI Kumiko (00420092)
SATO Dan (50468477)
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| Co-Investigator(Renkei-kenkyūsha) |
JEELANI Ghulam (80725820)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 感染症 / 分化 / トランスクリプトーム / 寄生虫 / 病原性 |
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| Research Abstract |
Metabolomics and transcriptomics analyses of encystation in Entamoeba invadens was conducted. We demonstrated a comprehensive view of metabolisms during encystation, including several unpredicted pathways and metabolites. These data should help us to further identify key regulatory points of gene expression and metabolic fluxes, and eventually understand elaborate regulation of entire metabolic network during encystation.
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Research Products
(24 results)
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[Journal Article] Transcriptional and functional analysis of trifluoromethionine resistance in Entamoeba histolytica2012
Author(s)
Penuliar, G. M., Furukawa, A., Nakada-Tsukui, K., Husain, A., Sato, D., and Nozaki, T
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Journal Title
J. Antimicrob. Chemother
Volume: 67
Pages: 375-386
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[Journal Article] Amebiasis in HIV-1-infected Japanese men : clinical features and response to therapy2011
Author(s)
Watanabe, K., Gatanaga, H., de Cadiz, A.E., Tanuma, J., Nozaki, T., Oka, S
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Journal Title
PLoS Negl. Trop. Dis
Volume: 5
Pages: e1318
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[Presentation] Biochemical and functional characterization of novel NADH kinase in the enteric protozoan parasite Entamoeba histolytica2013
Author(s)
Jeelani, G., Husain, A., Sato, D., Soga, T., Suematsu, M., Nozaki, T
Year and Date
20130000
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[Presentation] Metabolome of encystation in Entamoeba histolytica2012
Author(s)
Jeelani, G., Dan, S., Husain, A., Escueta-de Cadiz, Sugimoto, M., Soga, T., Suematsu, M., and Nozaki, T
Organizer
Metabolomics of Protozoan parasites
Place of Presentation
Glasgow, U.K.
Year and Date
20120910-14
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[Presentation] Organelle metabolomics of Entamoeba histolytica2012
Author(s)
Chiba, Y., Dan, S., Makiuchi, T., Jeelani, G., Soga, T., and Nozaki, T
Organizer
Metabolomics of Protozoan Parasites
Place of Presentation
Glasgow, U.K.
Year and Date
20120910-14
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[Presentation] Metabolic profiling of the protozoan parasite Entamoeba revealed activation of unpredicted pathway during encystation2012
Author(s)
Jeelani, G, , Sato, S., Husain, A., Escueta-de Cadiza, A., Sugimoto, M., Soga, T., Suematsu, M., and Nozaki, T
Year and Date
20120000
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