2013 Fiscal Year Final Research Report
Response and specific function of IFN-lambda3 against infectious diseases
| Project/Area Number |
23390117
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
MIZOAKMI Masashi 独立行政法人国立国際医療研究センター, その他部局等, その他 (40166038)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIYAMA Masaya 国立国際医療研究センター, 肝炎・免疫研究センター, 上級研究員 (20612427)
MURATA Kazumoto 国立国際医療研究センター, 肝炎・免疫研究センター, 室長 (40345971)
SUZUKI Yoshiyuki 名古屋市立大学, 大学院・システム自然科学研究科, 教授 (70353430)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | インターフェロンラムダ / 転写 / シグナル伝達 / 進化 / 受容体 |
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| Research Abstract |
We have newly developed a detection assay for IFN-lambda3 protein, being encoded by IL28B gene that predict the efficacy of pegylated interferon and ribavirin (Peg-IFN/RBV) therapy for chronic hepatitis C patients. Using this assay, we demonstrated that IFN-lambda3 levels in the supernatant of peripheral mononuclear cells stimulated with toll-like receptor 7 agonist or serum levels of IFN-lambda3 more favorably predict the efficay of Peg-IFN/RBV treatment rather than genetic variation of IL28B. We also demonstrated that human BDCA3+dendritic cells recognize hepatitis C virus and produce IFN-lambda3 through toll-like receptor 3 pathway.
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Research Products
(40 results)
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[Journal Article] Ex vivo induction of IFN-λ3 by a TLR7 agonist determines response to Peg-IFN/ ribavirin therapy in chronic hepatitis C patients2014
Author(s)
Murata K, Sugiyama M, Kimura T, Yoshio S, Kanto T, Kirikae I, Saito H, Aoki Y, Hiramine S, Matsui T, Ito K, Korenaga M, Imamura M, Masaki N, Mizokami M
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Journal Title
J Gastroenterol
Volume: 49(1)
Pages: 126-37
DOI
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[Journal Article] IL28B polymorphisms and clinical implications for hepatitis C virus infection in Uzbekistan2014
Author(s)
Khudayberganova D, Sugiyama M, Masaki N, Nishida N, Mukaide M, Sekler D, Latipov R, Nataliya K, Dildora S, Sharapov S, Usmanova G, Raxmanov M, Musabaev E, Mizokami M
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Journal Title
PLoS One
Volume: 24;9
Pages: e93011
DOI
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[Journal Article] Hepatitis C virus kinetics by administration of pegylated interferon-α in human and chimeric mice carrying human hepatocytes with variants of the IL28B gene2013
Author(s)
Watanabe T, Sugauchi F, Tanaka Y, Matsuura K, Yatsuhashi H, Murakami S, Iijima S, Iio E, Sugiyama M, Shimada T, Kakuni M, Kohara M, Mizokami M
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Journal Title
Gut
Volume: 62
Pages: 1340-6
DOI
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[Journal Article] Human blood dendritic cell antigen 3 (BDCA3)(+) dendritic cells are a potent producer of interferon-λ in response to hepatitis C virus2013
Author(s)
Yoshio S, Kanto T, Kuroda S, Matsubara T, Higashitani K, Kakita N, Ishida H, Hiramatsu N, Nagano H, Sugiyama M, Murata K, Fukuhara T, Matsuura Y, Hayashi N, Mizokami M, Takehara T
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Journal Title
Hepatology
Volume: 57
Pages: 1705-15
DOI
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[Journal Article] Targeted induction of interferon-λ in humanized chimeric mouse liver abrogates hepatotropic virus infection2013
Author(s)
Nakagawa S, Hirata Y, Kameyama T, Tokunaga Y, Nishito Y, Hirabayashi K, Yano J, Ochiya T, Tateno C, Tanaka Y, Mizokami M, Tsukiyama-Kohara K, Inoue K, Yoshiba M, Takaoka A, Kohara M
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Journal Title
PLoS One
Volume: 8
Pages: e59611
DOI
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[Journal Article] LecT-Hepa, a glyco-marker derived from multiple lectins, as a predictor of liver fibrosis in chronic hepatitis C patients2012
Author(s)
Ito K, Kuno A, Ikehara Y, Sugiyama M, Saito H, Aoki Y, Matsui T, Imamura M, Korenaga M, Murata K, Masaki N, Tanaka Y, Hige S, Izumi N, Kurosaki M, Nishiguchi S, Sakamoto M, Kage M, Narimatsu H, Mizokami M
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Journal Title
Hepatology
Volume: 56
Pages: 1448-56
DOI
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[Journal Article] Factors responsible for the discrepancy between IL28B polymorphism prediction and the viral response to peginterferon plus ribavirin therapy in Japanese chronic hepatitis C patients2012
Author(s)
Saito H, Ito K, Sugiyama M, Matsui T, Aoki Y, Imamura M, Murata K, Masaki N, Nomura H, Adachi H, Hige S, Enomoto N, Sakamoto N, Kurosaki M, Mizokami M, Watanabe S
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Journal Title
Hepatol Res
Volume: 42(10)
Pages: 958-65
DOI
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[Journal Article] Pre-treatment prediction of response to pegylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factors2011
Author(s)
Kurosaki M, Tanaka Y, Nishida N, Sakamoto N, Enomoto N, Honda M, Sugiyama M, Matsuura K, Sugauchi F, Asahina Y, Nakagawa M, Watanabe M, Sakamoto M, Maekawa S, Sakai A, Kaneko S, Ito K, Masaki N, Tokunaga K, Izumi N, Mizokami M
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Journal Title
J Hepatol
Volume: 54
Pages: 439- 448
DOI
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[Journal Article] The rs8099917 polymorphism, when determined by a suitable genotyping method, is a better predictor for response to pegylated alpha interferon/ribavirin therapy in Japanese patients than other single nucleotide polymorphisms associated with interleukin-28B2011
Author(s)
Ito K, Higami K, Masaki N, Sugiyama M, Mukaide M, Saito H, Aoki Y, Sato Y, Imamura M, Murata K, Nomura H, Hige S, Adachi H, Hino K, Yatsuhashi H, Orito E, Kani S, Tanaka Y, Mizokami M
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Journal Title
J Clin Microbiol
Volume: 49
Pages: 1853-60
DOI
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