2013 Fiscal Year Final Research Report
A novel functions of FGF2 and VEGF gene products: induction of resistance to antiangiogenic treatment
| Project/Area Number |
23390198
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KONDO Shigetada 徳島大学, ヘルスバイオサイエンス研究部, 准教授 (40304513)
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| Co-Investigator(Renkei-kenkyūsha) |
KUWANO Yuki 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (00563454)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 血管新生阻害 / VEGF / FGF２ / ノンコーディングRNA / 悪性進展 |
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| Research Abstract |
VEGF-targeted therapies have become an important treatment for a number of human malignancies. The VEGF inhibitors are actually effective in several types of cancers, however, the benefits are transiently, and the vast majority of patients who initially respond to the therapies will develop resistance.
I elucidate that one of mechanisms for the acquired resistance is the direct effect(s) of VEGF inhibitors on tumor cells expressing VEGF receptors. Treatment with bevacizumab and 5-FU induced two novel non-coding (nc)RNAs. These ncRNAs silenced p53 expression and inhibited p53 function. As the results, these ncRNAs induced malignant phenotypes in colon cancer cells, including over-activation of HIF1, angiogenic switching, resistance of apoptosis, aberrant cell cycle regulation, cancer stem-like phenotype, and resistance to bevacizumab. I revealed expression profiles of these ncRNAs in colon cancer patients; these ncRNA was overexpressed in patients treated with bevacizumab.
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[Journal Article] Chronic inhibition of tumor cell-derived VEGF enhances the malignant phenotype of colorectal cancer cells2013
Author(s)
Yamagishi, N., Teshima-Kondo, S. (corresponding author), Masuda, K., Nishida, K., Kuwano, Y., Nikawa, T., and Rokutan, K
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Journal Title
BMC Cancer
Volume: 13
Pages: 229
DOI
Peer Reviewed
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[Journal Article] Isoflavones Derived from Soy Beans Prevent MuRF1-Mediated Muscle Atrophy in C2C12 Myotubes through SIRT1 Activation2013
Author(s)
Hirasaka K, Maeda T, Ikeda C, Haruna M, Kohno S, Abe T, Ochi A, Mukai R, Oarada M, Teshima-Kondo, S., Ohno A, Okumura Y, Terao J, Nikawa T
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Journal Title
J Nutr Sci Vitaminol
Volume: 59(4)
Pages: 317-324
Peer Reviewed
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[Journal Article] Soy Glycinin Contains a Functional Inhibitory Sequence against Muscle Atrophy -Associated Ubiquitin Ligase Cbl-b2013
Author(s)
Abe T, Kohno S, Yama T, Ochi A, Suto T, Hirasaka K, Ohno A, Teshima-Kondo S, Okumura Y, Oarada M, Choi I, Mukai R, Terao J, Nikawa T
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Journal Title
Int J Endocrinol
Pages: 907565
DOI
Peer Reviewed
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[Journal Article] Cbl-b Is a Critical Regulator of Macrophage Activation Associated with Obesity-Induced Insulin Resistance in Mice2013
Author(s)
Abe T, Hirasaka K, Kagawa S, Kohno S, Ochi A, Utsunomiya K, Sakai A, Ohno A, Teshima-Kondo S, Okumura Y, Oarada M, Maekawa Y, Terao J, Mills EM, Nikawa T
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Journal Title
Diabetes
Volume: 62(6)
Pages: 1957-1969
DOI
Peer Reviewed
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[Journal Article] An Intracellular Fragment of Osteoactivin Formed by Ectodomain Shedding Translocated to the Nucleoplasm and Bound to RNA Binding Proteins2012
Author(s)
Utsunomiya K, Owaki K, Okumura Y, Yano M, Oto T, Suzuki E, Tamura S, Abe T, Kohno S, Ohno A, Hirasaka K, Teshima-Kondoh S, Nikawa T
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Journal Title
Biosci Biotechnol Biochem
Volume: 76(12)
Pages: 2225-2229
Peer Reviewed
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[Journal Article] Unloading stress disturbs muscle regeneration through perturbed recruitment and function of macrophages2012
Author(s)
Kohno S, Yamashita Y, Abe T, Hirasaka K, Oarada M, Ohno A, Teshima-Kondo S, Higashibata A, Choi I, Mills EM, Okumura Y, Terao J, Nikawa T
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Journal Title
J Appl Physiol
Volume: 112(10)
Pages: 1773-1782
DOI
Peer Reviewed
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[Presentation] IRS-1 転写産物による骨格筋の分化制御2013
Author(s)
平野俊介, 永野ひかる, 山岸直子, 数藤拓郎, 冨田知里, 安倍知紀, 宇都宮健郎, 越智ありさ, 真板綾子, , 二川健, 近藤茂忠
Organizer
第46回日本栄養・食糧学会中国・四国支部大会
Place of Presentation
山口県立大学(山口県山口市)
Year and Date
2013-11-16
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[Presentation] IRS-1 遺伝子産物による骨格筋細胞の脱分化2012
Author(s)
永野ひかる, 近藤茂忠, 河野尚平, 坂井敦子, 安倍知紀, 宇都宮健郎, 越智ありさ, 上地達也, 上村啓太, 池田千佳, 後藤春樹, 山下結衣, 坂東亜紀, 前田翼, 数藤拓郎, 真板綾子, 平坂勝也, 奥村裕司, 二川健
Organizer
第66回日本栄養・食糧学会大会
Place of Presentation
東北大学川内北キャンパス(宮城県仙台市)
Year and Date
20120518-24
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