2013 Fiscal Year Final Research Report
Signal networks among organ/tissue in the disorder of phosphate homeostasis
| Project/Area Number |
23390226
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MIYAMOTO KENICHI 徳島大学, ヘルスバイオサイエンス研究部, 教授 (70174208)
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| Co-Investigator(Kenkyū-buntansha) |
SEGAWA Hiroko 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (70325257)
KIDO Shinsuke 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 特任助教 (30437652)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | リン利尿 / 腎臓 / 繊維芽細胞増殖因子２３ (FGF23) / 骨細胞 |
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| Research Abstract |
Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that plays an important role in phosphate (Pi) transport in the proximal tubular cells. Klotho forms a specific receptor complex with FGF receptor that transmits signaling of FGF23 in the distal tubules. FGF23/klotho signaling leads to down-regulation of sodium-dependent Pi cotransporter (NaPi-II ) in the proximal tubules. In the present study, we investigated the mechanisms of down-regulation of renal Pi transporter by FGF23/klotho system and the production of FGF23 in bone cells. We show that klotho expression in the proximal tubules is induced by several conditions. Furthermore, inactivation of NaPi-IIc by PKC is the first step of FGF23/klotho dependent down-regulation of the transporters. Thus, FGF23/klotho signaling in the kidney-bone axis is essential for Pi homeostasis.
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Research Products
(40 results)
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[Journal Article] Critical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute response to PTH2013
Author(s)
Maeda A, Okazaki M, Baron DM, Dean T, Khatri A, Mahon M, Segawa H, Abou-Samra AB, Jüppner H, Bloch KD, Potts JT Jr, Gardella TJ
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Journal Title
Proc Natl Acad Sci USA
Volume: 110
Pages: 5864-5869
DOI
Peer Reviewed
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[Journal Article] Sodium-dependent phosphate cotransporters : Lessons from gene knockout and mutation studies2011
Author(s)
Miyamoto K, Haito-Sugino S, Kuwahara S, Ohi A, Nomura K, Ito M, Kuwahata M, Kido S, Tatsumi S, Kaneko I, Segawa H
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Journal Title
J Pharm Sci
Volume: 100(9)
Pages: 3719-3730
DOI
Peer Reviewed
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[Journal Article] Analysis of different complexes of type IIa sodium-dependent phosphate transporter in rat renal cortex using blue-native polyacrylamide gel electrophoresis2011
Author(s)
Tanimura A, Yamada F, Saito A, Ito M, Kimura T, Anzai N, Horie D, Yamamoto H, Miyamoto K, Taketani Y, Takeda E
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Journal Title
J Med Invest
Volume: 58(1.2)
Pages: 140-147
URL
Peer Reviewed
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[Presentation] Molecular mechanisms of cadmium (Cd) dependent fibroblast growth factor 23 secretion in bone2012
Author(s)
Kido S, Fujiwara M, Nomura K, Sasaki S, Shiozaki Y, Segawa H, Tatsumi S, Miyamoto K
Organizer
Americal Society Nephrology, Kidney Week
Place of Presentation
San Diego Convention Center, CA, USA
Year and Date
2012-11-02
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[Presentation] Mechanisms of hyperphosphatemia in the osteocyte-abelated mice2012
Author(s)
Tatsumi S, Kamatani T, Nomura K, Yoshimi A, Shiozaki Y, Sasaki S, Manabe M, Kido S, Segawa H, Miyamoto K
Organizer
Americal Society Nephrology, Kidney Week
Place of Presentation
San Diego Convention Center, CA, USA
Year and Date
2012-11-02
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[Presentation] Role of Sodium-Dependent Phosphate(Pi)Transporter(Npt2b)on Salivary Pi Secretion2011
Author(s)
Segawa H, Mukai T, Ohnishi S, Sasaki S, Ohi A, Kuwahara S, Kido S, Tatsumi S, Ishikawa Y, Ueda O, Horiba N, Jishage K, Fukushima N, Miyamoto K
Organizer
J Am Soc Nephrol
Place of Presentation
Pennsylvania Convention Center in Philadelphia, USA
Year and Date
2011-11-11
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[Presentation] Molecular Consequences of the SLC34A3 Mutations of Hereditary Hypophosphatemic Rickets with Hypercalciuria(HHRH)2011
Author(s)
Ohi A, Haito Sugino S, Ito M, Shiozaki Y, Nomura K, Kusaka Y, Sasaki S, Ohnishi S, Yamaguchi S, Kido S, Tatsumi S, Segawa H, Miyamoto K
Organizer
J Am Soc Nephrol
Place of Presentation
Pennsylvania Convention Center in Philadelphia, USA
Year and Date
2011-11-10
