2013 Fiscal Year Final Research Report
Systematic analyses of pathogenesis and cancer stem cell of pediatric solid tumors and development of novel therapeutic strategies
| Project/Area Number |
23390269
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
TAKITA Junko 東京大学, 医学部附属病院, 准教授 (00359621)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SANADA Masashi 京都大学, 医学(系)研究科(研究院) (20529044)
|
|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Keywords | 小児固形腫瘍 / Pediatric solid tumors / 横紋筋肉腫 / 次世代シークエンサー / 神経芽腫 |
|---|
| Research Abstract |
Pediatric solid tumors are one of the significant causes of death among children, and thus, development for new therapeutic strategy for intractable pediatric solid tumors is a global problem. To identify molecular targets of pediatric solid tumors and regulators of cancer stem cells, we performed target sequencing and exome sequencing using next generation sequencing technology. Target sequencing of 80 polycomb protein genes in 96 of neuroblastomas revealed that ASH1L mutations occurred in about 10% of cases. Thus, this gene is one of the candidate target for cancer stem cells regulators of neuroblastoma. In exome analysis of 16 cases of rhabdomyosarcoma (RMS), we identified FGFR4 pathway mutations in about 30% of all cases, and this pathway mutation was more frequently detected in embryonal subtype. Therefore, the inhibitor of FGFR4 pathway could be one of the promising therapeutic molecule for embryonal RMS.
|
-
-
-
-
-
-
-
[Journal Article] Comparison of intravenous with oral busulfan in allogeneic hematopoietic stem cell transplantation with myeloablative conditioning regimens for pediatric acute leukemia2013
Author(s)
Kato M, Takahashi Y, Tomizawa D, Okamoto Y, Inagaki J, Koh K, Ogawa A, Okada K, Cho Y, Takita J, Goto H, et al
-
Journal Title
Biol Blood Marrow Transplant
Volume: 19
Pages: 1690-1694
DOI
Peer Reviewed
-
-
-
-
-
-
-
[Journal Article] Aggressive transformation of juvenile myelomonocytic leukemia associated with duplication of oncogenic KRAS in consequence of acquired uniparental disomy2013
Author(s)
Kato M, Yasui N, Seki M, Kishimoto H, Sato-Otsubo A, Hasegawa D, Kiyokawa N, Hanada R. Ogawa S, Manabe A, Takita J, Koh K
-
Journal Title
J Pediatr
Volume: 162
Pages: 1285-1288
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
[Journal Article] IDH1 and IDH2 mutations are rare in pediatric myeloid malignancies2011
Author(s)
Oki K, Takita J, Hiwatari M, Nishimura R, Sanada M, Okubo J, Adachi M, Sotomatsu M, Kikuchi A, Igarashi T, Hayashi Y, Ogawa S
-
Journal Title
Leukemia
Volume: 25
Pages: 382-384
DOI
-
-
-
-
[Journal Article] Biallelic DICER1 mutations in sporadic pleuropulmonary blastoma
Author(s)
Seki M, Yoshida K, Shiraishi Y, Shimamura T, Sato Y, Nishimura R, Okuno Y, Chiba K, Tanaka H, Kato K, Kato M, Hanada R, Nomura Y, Park MJ, Ishida T, Oka A, Igarashi T, Miyano S, Hayashi Y, Ogawa S, Takita J
-
Journal Title
Cancer Res
Volume: 74
Pages: 2742-9
DOI
Peer Reviewed
-
[Presentation] Genetic Landscapes Of Childhood T-Cell Acute Lymphoblastic Leukemia2013
Author(s)
Seki M, Nishimura R, Hoshino N, Okuno Y, Yoshida K, Shiraishi Y, Sanada M, Miyano S, Hayashi Y, Ogawa S, Takita J
Organizer
American Society of Hematology 2013
Place of Presentation
New Orleans, U.S.A
Year and Date
20131207-10
-
-
[Presentation] The Genetic landscapes of rhabdomyosarcoma2013
Author(s)
Nishimura R, Yoshida K, Shiraishi Y, Okuno Y, Seki M, Hoshimo N, Sanada M, Hayashi Y, Miyano S, Ogawa S, Takita J
Organizer
The 45th Congress of the International Society of Paediatric Oncology
Place of Presentation
Hong Kong
Year and Date
20130925-28
-
[Presentation] Exome sequencing analysis in rhabdomyosarcoma including metastatic or relapsed tumors2013
Author(s)
Nishimura R, Yoshida K, Shiraishi Y, Okuno Y, Seki M, Hoshino N, Sanada M, Hayashi Y, Miyano S, Ogawa S, Takita J
Organizer
9th ASPR Congress
Place of Presentation
Malaysia
Year and Date
20130509-13
-
[Presentation] Genome-wide analyses of pleuropulmonary blastoma2013
Author(s)
Seki M, Nishimiura R, Hoshino N, Okuno Y, Yoshida K, Shiraishi Y, Sanada M, Kato K, Miyano S, Hayashi Y, Ogawa S, Takita J
Organizer
9th ASPR Congress
Place of Presentation
Malaysia
Year and Date
20130509-13
-
[Presentation] Genome-wide approach to identify gene targets of pleuropulmonary blastoma2013
Author(s)
Seki M, Nishimura R, Okuno Y, Yoshida K, Shiraishi Y, Sanada M, Kato K, Hayashi Y, Miyano S, Ogawa S, Takita J
Organizer
American Association for Cancer Research 2013
Place of Presentation
Washington DC, U.S.A.
Year and Date
20130406-10
-
-
-
-
[Presentation] Whole-exome sequencing of advanced neuroblastomas using nextgeneration sequencer2012
Author(s)
Nishimura R, Takita J, Yoshida K, Shiraishi Y, Okubo J, Hoshino N, Sanada M, Hayashi Y, Miyano S, Igarashi T, Ogawa S
Organizer
The 8 th Congress of Asian Society for Pediatric Research
Place of Presentation
Seoul
Year and Date
20120517-19
-
-
-
-
