Amyloid imaging with PET and florbetapir F18 in geriatric depression

2014 Fiscal Year Final Research Report

• Project/Area Number: 23390292
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Nippon Medical School
• Principal Investigator: YOSHIRO Okubo 日本医科大学, 医学(系)研究科(研究院), 教授 (20213663)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Hidenori 日本医科大学, 大学院医学研究科, 教授 (30221328) ; TATENO Amane 日本医科大学, 医学部, 准教授 (50297917)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: アミロイドイメージング / アルツハイマー病 / うつ病 / PET

Outline of Final Research Achievements

We performed amyloid positron emission tomography (PET) with [18F]florbetapir in patients with Alzheimer's disease (AD), mild cognitive impairment (MCI), and older healthy controls (OHC). A cutoff values for measuring AD-like levels of amyloid for SUVR was well differentially diagnosed and clinically defined AD from OHC. We examined patients with MCI with a history of geriatric depression (GD) and OHC to evaluate the effect of beta-amyloid (Aβ) pathology. Compared to patients without Aβ (GD-Aβ), patients with Aβ (GD+Aβ) did not differ in terms of age, cognitive function, severity of depression and ADL, and brain atrophy. But GD+Aβ had significantly older average age at onset of GD. Our results showed that the rate of Aβ positivity was higher in late-onset GD and that onset-age was associated with SUVR, suggesting that the later the onset of GD, the more Aβ pathology affected its onset.

Free Research Field

精神医学