Development of new diagnosis approaches for detecting cardiovascular dysfunction in patients with respiratory disease using positron emission tomography

2013 Fiscal Year Final Research Report

• Project/Area Number: 23390294
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: YOSHINAGA Keiichiro 北海道大学, 医学(系)研究科(研究院), 特任教授 (30435961)
• Co-Investigator(Kenkyū-buntansha): KATOH Chietsugu 北海道大学, 保健科学研究院, 教授 (10292012) ; TSUJINO Ichizo 北海道大学, 北海道大学病院, 講師 (00344507) ; MANABE Noriko 北海道大学, 北海道大学病院, 講師 (70463742)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Keywords: 核医学 / 肺高血圧症 / 心サルコイドーシス / 心筋代謝 / 心筋炎症 / 交感神経機能

Research Abstract

Right ventricular (RV) oxidative metabolism increased in patients with PH in association with prognostic markers such as mean PAP, PVR, and BNP.. Patients with WHO functional class II to III PH also had increased RV power and efficiency. These findings may indicate a myocardial energetics adaptation response to increasing PAP. Intensive PH treatments reduced RV oxidative metabolism and improved RV volume/oxygen consumption index. In this project, we developed possible new prognostic markers and useful treatment monitor markers in patients with PH.
F-18 flucorodeoxyglucose (FDG) has been considered to be a diagnostic marker of cardiac involvement sarcoidosis (CS). We reported the association between the ECG abnormalities and positive F-18 FDG uptake in LV. This indicates active inflammation is associated with rhythm abnormalities. We also reported the reduced cardiac sympathetic nervous function in CS. These findings may contribute the understanding the disease mechanisms.

Research Products

• [Journal Article] Attenuated right ventricular energetics evaluated using C-11 acetate PET in patients with pulmonary hypertension (2014)
  • Author(s): Yoshinaga K, Ohira H, Tsujino I, Oyama-Manabe N, Mielniczuk L, Beanlands R, Katoh C, Kasai K, Manabe O, Sato T, Fujii S, Ito Y, Tomiyama Y, Nishimura M, Tamaki N
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 41 Pages: 1240-50
  • Peer Reviewed
• [Journal Article] Electrocardiographically gated 11C-hydroxyephedrine PET for the simultaneous assessment of cardiac sympathetic and contractile functions (2014)
  • Author(s): Magota K, Hattori N, Manabe O, Naya M, Oyama-Manabe N, Shiga T, Kuge Y, Yamada S, Sakakibara M, Yoshinaga K, Tamaki N
  • Journal Title: Ann Nucl Med Volume: 3 Pages: 187-95
  • Peer Reviewed
• [Journal Article] Recommendations for 18F-Fluorodeoxyglucose positron emission tomography imaging for cardiac sarcoidosis. -Japanese Society of Nuclear Cardiology Recommendations (2014)
  • Author(s): Ishida Y, Yoshinaga K, Miyagawa M, Moroi M, Kondoh C, Kiso K, Kumita S
  • Journal Title: Ann Nucl Med Volume: (in press)
  • Peer Reviewed
• [Journal Article] Elevated <18>~F-fluorodeoxyglucose uptake in the interventricular septum is associated with atrioventricular block in patients with suspected cardiac involvement sarcoidosis (2013)
  • Author(s): Manabe O, Ohira H, Yoshinaga K, Sato T, Klaipetch A, Oyama-Manabe N, Ito Y, Tsujino I, Nisimura M, Tamaki N
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 40:10 Pages: 1558-66
  • Peer Reviewed
• [Journal Article] Ischemic memory imaging using metabolic radiopharmaceuticals-overview in clinical settings and ongoing investigations (2013)
  • Author(s): Yoshinaga K, Naya M, Shiga T, Suzuki E, Tamaki N
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 41 Pages: 384-393
  • Peer Reviewed
• [Journal Article] Myocardial blood flow quantification using positron-emission tomography-analysis and practice in the clinical setting- (2013)
  • Author(s): Yoshinaga K, Tomiyama Y, Suzuki E, Tamaki N
  • Journal Title: Circ J Volume: 77:7 Pages: 1662-1671
  • Peer Reviewed
• [Journal Article] Interrelation between myocardial oxidative metabolism and diastolic function in patients undergoing surgical ventricular reconstruction (2013)
  • Author(s): Chiba S, Naya M, Iwano H, Yoshinaga K, Katoh C, Manabe O, Yamada S, Wakasa S, Kubota S, Matsui Y, Tamaki N, Tsutsui H
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 40 Pages: 349-355
  • Peer Reviewed
• [Journal Article] Quantification of regional myocardial blood flow estimation with three-dimensional dynamic rubidium-82 PET and modified spillover correction model (2012)
  • Author(s): Katoh C, Yoshinaga K, Klein R, Kasai K, Tomiyama Y, Manabe O, Naya M, Sakakibara M, Tsutsui H, deKemp RA, Tamaki N
  • Journal Title: J Nucl Cardiol Volume: 19:4 Pages: 763-74
  • Peer Reviewed
• [Journal Article] Effects of surgical ventricular reconstruction and mitral complex reconstruction on cardiac oxidative metabolism and efficiency innNonischemic and ischemic dilated cardiomyopathy (2011)
  • Author(s): Sugiki T, Naya M, Manabe O, Wakasa S, Kubota S, Chiba S, Iwano H, Y amada S, Y oshinaga K, T amaki N, T sutsui H, Matsui Y
  • Journal Title: JACC Cardiovasc Ima Volume: 4 Pages: 762-70
  • Peer Reviewed
• [Journal Article] Incremental diagnostic value of regional myocardial blood flow quantification over relative perfusion imaging with generator produced rubidium-82 (2011)
  • Author(s): Yoshinaga K, Katoh C, Manabe O, Klein R, RA, T sutsui H, T amaki N
  • Journal Title: PET .Circ J Volume: 75 Pages: 2628-34
  • Peer Reviewed
• [Presentation] Left ventricular F-18 fluorodeoxyglucose uptake associated with myocardial autonomic dysfunction in patients suspected with cardiac sarcoidosis (2014)
  • Author(s): Yoshinaga K, Ohira H, T sujino I, Katoh C
  • Organizer: American College of Cardiology 63th Annual Scientific Session&Expo.Walter E
  • Place of Presentation: Washington Convention Center (Washington, DC )
  • Year and Date: 20140329-31
• [Presentation] Right ventricular F-18 fluorodeoxyglucose uptake associated with broader left ventricular involvements in patients suspected with cardiac sarcoidosis (2013)
  • Author(s): Yoshinaga K, Manabe O, Ohira H, Tsujino I, Sato T, Nishimura M, Tamaki N
  • Organizer: Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2013 Annual Meeting
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 20130608-12
• [Presentation] Effects of intensified pulmonary hypertension specific vasodilator therapy on myocardial oxidative metabolism aassessed using C-11 PET in patients with pulmonary hypertension (2013)
  • Author(s): Yoshinaga K, Ohira H, Tsujino I, Manabe O
  • Organizer: American College of Cardiology 62th Annual Scientific Session&Expo
  • Place of Presentation: the Moscone Center (San Francisco, California )
  • Year and Date: 20130309-11
• [Presentation] Prone position acquisition of myocardial 123I metaiodobenzylguanidine (MIBG)SPECT shows closer regional uptake to 11C hydroxyephedrine PET (2012)
  • Author(s): Yoshinaga K, Katho C, Mori Y, Tomiyama Y, Manabe O, Kasai K, Chiba S, Magota K, Tamaki N
  • Organizer: Society of Nuclear Medicine 2012 Annual Meeting
  • Place of Presentation: Miami Beach, Florida
  • Year and Date: 20120609-13
• [Presentation] Elevated right ventricular oxidative metabolism in patients with chronic thromboembolic pulmonary hypertension (CTEPH) or pulmonary arterial hypertension (P AH) using C-11 Acetate PET (2011)
  • Author(s): Yoshinaga K, Ohira H, T sujino I, Manabe O
  • Organizer: American Heart Association Scientific Sessions 2011
  • Place of Presentation: Orlando, Florida
  • Year and Date: 20111112-16