2013 Fiscal Year Final Research Report

Development of minimally-invasive interventional radiological therapy of primary aldosteronism based on adrenal venous sampling.

Research Project

Project/Area Number	23390296
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	Radiation science
Research Institution	Tohoku University
Principal Investigator	TAKASE KEI 東北大学, 大学病院, 准教授 (60361094)
Co-Investigator(Kenkyū-buntansha)	OOTA Makoto 東北大学, 流体科学研究所, 准教授 (20400418) MORIMOTO Ryou 東北大学, 大学病院, 助教 (30547394) SEIJI Kazumasa 東北大学, 大学病院, 講師 (50400247) SATOU Fumitoshi 東北大学, 大学病院, 講師 (70343051)
Co-Investigator(Renkei-kenkyūsha)	SATOU Miho 東北大学, 医学系研究科, 助手 (70579622)
Project Period (FY)	2011-04-01 – 2014-03-31
Keywords	primary aldosteronism / adrenal venou sampring / IVR / RF ablation / hypertension
Research Abstract	Real-size vascular model including adrenal venous tributaries was generated, which was utilized for simulation of catheterization. Experimental study using bovine adrenal gland showed that 3 insertion patterns of bipolar needles enables complete ablation of adrenal adenoma with 10 to 25-mm in diameter. Adjacent organ with 5-mm intervening adipose tissue was preserved. Initial clinical interventional radiological treatment achieved normalization of plasma aldosterone level and amount in 24-hour urine specimen. Cost-effectiveness of this treatment was also proven.