2013 Fiscal Year Final Research Report
Surgical Therapy for the neuropathic pain.
Project/Area Number |
23390375
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Anesthesiology/Resuscitation studies
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Research Institution | Kyoto University |
Principal Investigator |
INADA Yuji 京都大学, 再生医科学研究所, 非常勤講師 (90254515)
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Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Tatsuo 京都大学, 再生医科学研究所, 准教授 (70227908)
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Project Period (FY) |
2011-04-01 – 2014-03-31
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Keywords | カウザルギー / 神経因性疼痛 / 慢性疼痛 / 人工神経 / アロデニア / コラーゲン / CRPS / 難治性疼痛 |
Research Abstract |
Animal experimental model was made in Beagle dogs on the neuropathic pain. Using this mode the mechanism was studied concerning the surgical approach which refers the local and central nerve systems with electrophysiological and pathological, biochemical methods to reveal the main reason of on-set of the neuropathic pain. We have already found in clinically that the local recovery of the peripheral nerve reads to reduce the neuropathic pain, the study revealed one part of this mechanism. Since the animal model of a neuropathic pain was established by ligation of the peripheral nerve, we applied it for the sciatic nerve of Beagle dogs as a model of the neuropathic nerve. For the new treatment, we challenged to replace the damaged site with a nerve conduit composed of PGA and collagen and evaluated nether peripheral repair may contribute the morbus of the neuropathic pain.
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Research Products
(106 results)
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[Journal Article] A novel surgical marking system for small peripheral lung nodules based on radio frequency identification technology : Feasibility study in a canine model2014
Author(s)
Kojima, F., Sato, T., Takahata, H., Okada, M., Sugiura, T., Oshiro, O., Date, H., Nakamura, T
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Journal Title
J Thorac Cardiovasc Surg
Volume: 147
Pages: 1384-9
DOI
Peer Reviewed
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[Journal Article] Regeneration of Canine Inferier Alveolar Nerve by Polyglycolic Acid-Collagen Tube with Platelet Rich Plasma2013
Author(s)
Shigeno, K., Kaneko, M., Wakatsuki, M., Nakada, A., Hashimoto, Y., Honda, M., Inada, Y., Nakamura, T
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Journal Title
Int J Artif Organs
Volume: 36
Pages: 571
Peer Reviewed
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[Journal Article] Improvement of eustachian tube function by Tissue-Engineered regeneration of mastoid air cells2013
Author(s)
Kanemaru, S., Umeda, H., Yamashita, M., Hiraumi, H., Hirano, S., Nakamura, T., Ito, J
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Journal Title
Laryngoscope
Volume: 123
Pages: 472-476
DOI
Peer Reviewed
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[Journal Article] Functional regeneration of laryngeal muscle using bone marrow-derived stromal cells2013
Author(s)
Kanemaru, S., Kitani, Y., Ohno, S., Shigemoto, T., Kojima, T., Ishikawa, S., Mizuta, M., Hirano, S., Nakamura, T., Dezawa, M
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Journal Title
Laryngoscope
Volume: 123
Pages: 2728-34
DOI
Peer Reviewed
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[Journal Article] Protracted delay in taste sensation recovery after surgical lingual nerve repair : a case report2013
Author(s)
Seo, K., Inada, Y., Terumitsu, M. Nakamura, T., Shigeno, K., Tanaka, Y., Tsurumaki, T., Kurata, S., Matsuzawa, H
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Journal Title
Journal of Medical Case Reports
Volume: 7
Pages: 77-81
DOI
Peer Reviewed
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[Journal Article] Transforming Growth Factor β 3 for the prevention of vocal fold scarring2012
Author(s)
Ohno, S., Hirano, S., Kanemaru, S., Kitani, Y., Kojima, T., Ishikawa, S., Mizuta, M., Tateya, I., Nakamura, T., Ito, J
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Journal Title
Laryngoscope
Volume: 122
Pages: 583-589
DOI
Peer Reviewed
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[Journal Article] Regeneration of canine inferior alveolar nerve by polyglycolic acid-collagen tube2012
Author(s)
Shigeno, k., Nakada, A., Kaneko, M., Wakatsuki, M., Hashimoto, Y., Inada, Y., Nakamura, T
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Journal Title
Int Artif Organs
Volume: 35(8)
Pages: 569
Peer Reviewed
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[Journal Article] Promotion of bone repairing by use of novel Collagen scaffold in Rabbit skull defect model2012
Author(s)
Wakatsuki, M., Kaneko, M., Sasauchi, K., Nakada, A., Shigeno, K., Nakamura, T
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Journal Title
Int Artif Organs
Volume: 35(8)
Pages: 591
Peer Reviewed
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[Journal Article] Artificial trachea and In situ tissue engineering : twelve gean-follow up.in canine model2012
Author(s)
Nakamura, T., Fumitsugu, K., Sato, T., Nakada, A., Wakatsuki, M., Sasauchi, K., Kida, N., Kanemaru, S., Omori, K., Kaneko, M., Shigeno, k., Inada, Y., Endo, K
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Journal Title
Int Artif Organs
Volume: 35(8)
Pages: 608
Peer Reviewed
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[Journal Article] Role of Circulating Mesenchymal Stem Cells in Vocal Fold Wound Healing2012
Author(s)
Ohno, S., Hirano, S., Kanemaru, S., Mizuta, M., Ishikawa, S., Tateya, I., Nakamura, T., Ito, J
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Journal Title
Laryngoscope
Volume: 122(11)
Pages: 2503-2510
DOI
Peer Reviewed
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[Journal Article] Increased expression of phosphatidylcholine (16 : 0/18:1) and (16:0/18:2) in thyroid papillary cancer2012
Author(s)
Ishikawa, S., Tateya, I., Hayakawa, T., Masaki, N., Takizawa, Y., Ohno, S., Kojima, T., Kitani, Y., Kitamura, M., Hirano, S., Setou, M., Ito, J
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Journal Title
PLoS One
Volume: 7(11)
Pages: e48873
DOI
Peer Reviewed
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[Journal Article] Implantation of an atelocollagen sponge with autologous bone marrow-derived mesenchymal stromal cells for treatment of vocal fold scarring in a canine model2011
Author(s)
Ohno, S., Hirano, S., Kanemaru, S., Kitani, Y., Kojima, T., Tateya, I.Nakamura, T., Ito, J
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Journal Title
Ann Otol Rhinol Laryngol
Volume: 120
Pages: 401-408
Peer Reviewed
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[Journal Article] Prevention of buccal mucosa scarring with transforming growth factor β 32011
Author(s)
Ohno, S., Hirano, S., Kanemaru, S., Tateya, I., Kitani, Y., Kojima, T., Nakamura, T., Ito, J
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Journal Title
Laryngoscope
Volume: 121
Pages: 1404-1409
DOI
Peer Reviewed
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[Journal Article] Feasibility study of corticosteroid treatment for esophageal ulcer after EMR in a canine model2011
Author(s)
Honda, M., Nakamura, T., Hori, Y., Shionoya, Y., Yamamoto, K., Nishizawa, Y., Kojima, F., Shigeno, K
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Journal Title
Journal of Gastroenterology
Volume: 46
Pages: 866-872
DOI
Peer Reviewed
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[Journal Article] Use of adipose-derived stromal cells for prevention of esophageal stricture after circumferential EMR in a canine model2011
Author(s)
Honda, M., Hori, Y., Nakada, A., Uji, M., Nishizawa, Y., Yamamoto, K., Kobayashi, T., Shimada, H., Kida, N., Sato, T., Nakamura, T
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Journal Title
Gastrointestinal Endoscopy
Volume: 73
Pages: 777-784
DOI
Peer Reviewed
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[Journal Article] Development of a novel antiadhesive material, alginate flakes, ex vivo and in vivo2011
Author(s)
Hirasaki, Y., Fukunaga, M., Kidokoro, A., Hashimoto, A., Nakamura, T., Tsujimoto, H., Hagiwara, A
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Journal Title
Surg today
Volume: 41
Pages: 970-977
DOI
Peer Reviewed
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[Journal Article] Regeneration of radiation damaged salivary glands with adipose-derived stromal cells2011
Author(s)
Kojima, T., Kanemaru, S., Hirano, S., Tateya, I., Ohno, S., Nakamura, T., Ito, J
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Journal Title
Laryngoscope
Volume: 121
Pages: 1864-1869
DOI
Peer Reviewed
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[Journal Article] The protective efficacy of basic fibroblast growth factor in radiation-induced salivary gland dysfunction in mice2011
Author(s)
Kojima, T., Kanemaru, S., Hirano, S., Tateya, I., Suehiro, A., Kitani, Y., Kishimoto, Y., Ohno, S., Nakamura, T., Ito, J
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Journal Title
Laryngoscope
Volume: 121
Pages: 1870-1875
DOI
Peer Reviewed
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[Journal Article] Reduction of air leaks in a canine model of pulmonary resection with a new staple-line buttress2011
Author(s)
Hashimoto, A., Kuwabara, M., Hirasaki, Y., Tsujimoto, H., Torii, T., Nakamura, T., Hagiwara, A
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Journal Title
J Thorac Cardiovasc Surg
Volume: 142
Pages: 366-371
DOI
Peer Reviewed
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[Journal Article] Survival and treatments in patients with incompletely resected thymoma
Author(s)
Hamaji, M., Omasa, M., Chen, F., Yamada, T., Sato, M., Menju, T., Sato, T., Aoyama, A., Sonobe, M., Bando, T., Date, H
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Journal Title
Asian Thoracic and Cardiovascular Annals
Volume: (in press)
Peer Reviewed
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[Presentation] Novel tracheal prosthesis using in situ Tissue Engineering2013
Author(s)
Nakamura, T., Kojima, F., Sato, T., Hamaji, M., Kaneko, M., Kanemaru, S., Nakada, A., Omori, K., Shigeno, K., Wakatsuki, M., Endo, K
Organizer
40th Annual ESAO Congress
Place of Presentation
Scotland
Year and Date
20130911-14
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[Presentation] Regeneration of Canine Inferier Alveolar Nerve by Polyglycolic Acid-Collagen Tube with Platelet Rich Plasma2013
Author(s)
Shigeno, K., Kaneko, M., Wakatsuki, M., Nakada, A., Hashimoto, Y., Honda, M., Inada, Y., Nakamura, T
Organizer
40th Annual ESAO Congress
Place of Presentation
Scotland
Year and Date
20130911-14
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[Presentation] Impact of Transmission Power Variation to the Position Estimation Error Performance of RFID-tag Assisted Surgery Support System2013
Author(s)
Takahata, H., Sugiura, T., Kojima, F., Sato, T., Okada, M., Oshiro, O
Organizer
International Conference of the IEEE Engineering in Medicine and Biology Society(EMBC'2013)
Place of Presentation
Osaka
Year and Date
20130703-07
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[Presentation] The effect of astaxanthin on vocal fold wound healing2013
Author(s)
Mizuta, M., Hirano, S., Tateya, I., Hiwatashi, N., Kanemaru, S. Ito, J
Organizer
The 134th American Laryngological Association
Place of Presentation
Orlando
Year and Date
20130410-11
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[Presentation] Experimental study of new vascularized composite allotransplantation : Anorectal transplantation with rats, dogs and human cadavers. 11th Meeting of the International Hand and Composite Tissue2013
Author(s)
Araki, J., Nishizawa, Y., Sato, T., Naito, M., Akita, K., Tashiro, K., Iida, T., Koshima, I
Organizer
Allotransplantation Society
Place of Presentation
Wroctaw
Year and Date
2013-08-29
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[Presentation] Anorectal transplantation research for the stoma patients2013
Author(s)
Araki. J., Nishizawa, Y., Sato, T., Naito, M., Akita, K., Tashiro, K., Iida, T., Koshima, I
Organizer
6th European Plastic Surgery Research Council
Place of Presentation
Hamburg
Year and Date
2013-08-22
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[Presentation] Anorectal transplantation research with rats, dogs and human cadavers2013
Author(s)
Araki, J., Nishizawa, Y., Sato, T., Naito, M., Akita, K., Tashiro, K., Iida, T., Koshima, I
Organizer
World Society of Reconstructive Microsurgery 2013 Congress
Place of Presentation
Chicago
Year and Date
2013-07-11
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[Presentation] In-Vivo Localization of Micro Radio Frequency Identification Tag : Concept Proof of Novel Surgical Marking System for Small Peripheral Lung Nodule2013
Author(s)
Kojima, F., Sato, T., Takahata, H., Okada, M., Sugiura, T., Oshiro, O., Date, H., Nakamura. T
Organizer
第21回アジア胸部心臓血管外科学会
Place of Presentation
神戸
Year and Date
2013-04-06
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[Presentation] PROMOTION OF BONE REPAIRING BY USE OF NOVEL COLLAGEN SCAFFOLDS IN RABBIT SKULL DEFECT MODEL2012
Author(s)
Wakatsuki, M., Kaneko, M., Sasauchi, K., Nakada, A., Shigeno, K., Nakamura, T
Organizer
39th Annual ESAO Congress
Place of Presentation
Rostock (Germany)
Year and Date
20120926-29
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[Presentation] REGENERATION OF CANINE INFERIER ALVEOLAR NERVE BY POLGLY-COLIC ACID-COLLAGEN TUBE2012
Author(s)
Shigeno, K., Shionoya, Y., Nakada, A., Kaneko, M., Wakatsuki, M., Hashimoto, Y., Inada, Y., Nakamura, T
Organizer
39th Annual ESAO Congress
Place of Presentation
Rostock (Germany)
Year and Date
20120926-29
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[Presentation] Role of Circulating Mesenchymal Stem Cells in Vocal Fold Wound Healing2012
Author(s)
Ohno, S., Hirano, S., Kanemaru, S., Mizuta, M., Ishikawa, S., Tateya, I., Nakamura, T., Ito, J
Organizer
The 92nd Annual Meeting of The American Broncho-Esophagological Association
Place of Presentation
San Diego (USA)
Year and Date
2012-04-19
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[Presentation] Transforming Growth Factor beta3 for the prevention of vocal fold scarring2011
Author(s)
Ohno, S., Hirano, S., Kanemaru, S., Tateya, I., Kada, S., Ito, J
Organizer
The Voice Foundation's 40th Annual Symposium : Care of the Professional Voice
Place of Presentation
Philadelphia (USA)
Year and Date
2011-06-02
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