The role of intrinsic immunity for EBV-mediated nasopharyngeal carcinogenesis

2014 Fiscal Year Final Research Report

• Project/Area Number: 23390396
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kanazawa University
• Principal Investigator: YOSHIZAKI Tomokazu 金沢大学, 医学系, 教授 (70262582)
• Co-Investigator(Kenkyū-buntansha): SUGIMOTO Hisashi 金沢大学, 附属病院, 講師 (20547179) ; WAKISAKA Naohiro 金沢大学, 附属病院, 講師 (70377414) ; KONDO Satoru 金沢大学, 附属病院, 助教 (70436822) ; ENDO KAzuhira 金沢大学, 附属病院, 助教 (30547154)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 上咽頭癌 / Epstein-Barr ウイルス / 内因性免疫 / 中咽頭癌 / ヒトパピローマウイルス / APOBEC

Outline of Final Research Achievements

Intrinsic immunity, including APOBEC family, is a defense system inherent to a cell itself. Viral oncogenesis by EBV, HPV has been a matter of issue these days. We identified that APOBEC3G was overexpressed in both EBV-pisitive nasopharyngeal cancer and HPV-positive oropharyngeal cancer tissues. Moreover, APOBEC specific G to A, C to T mutations were frequently detected in HPV-E2 region. These results suggest that intrinsic immunity, especially, APOBEC3G, is associated with HPV-mediated oropharyngeal oncogenesis.

Free Research Field

耳鼻咽喉科・頭頸部外科