• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2013 Fiscal Year Final Research Report

Cellular mechanism in thrombin mediated HMGB1 release. Effect of cluster formation of HMGB1 on the cell-surface receptors.

Research Project

  • PDF
Project/Area Number 23390412
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionKagoshima University

Principal Investigator

MARUYAMA Ikuro  鹿児島大学, 医歯(薬)学総合研究科, 特任教授 (20082282)

Co-Investigator(Kenkyū-buntansha) KAWAHARA Koichi  大阪工業大学, 工学部生命工学科, 特任教授 (10381170)
ITO Takashi  鹿児島大学, 大学院・医歯学総合研究科, 特任講師 (20381171)
OYAMA Yoko  鹿児島大学, 大学院・医歯学総合研究科, 特任助教 (20583470)
HASHIGUCHI Teruto  鹿児島大学, 大学院・医歯学総合研究科, 教授 (70250917)
Project Period (FY) 2011-04-01 – 2014-03-31
KeywordsPAMPs / DAMPs / HMGB1 / inflammasome
Research Abstract

HMGB1, a representative danger associated molecular patterns, DAMP is released from almost all nucleated necrotic cells and activated epithelial cells including endothelial cells. The HMGB1 released out of the cells acts on Toll Like receptors(TLR)-2,TLR-4 and receptor for advanced glycation endproducts, RAGE. If the cells were primed by preceding PAMPs, pathogen associated molecular patterns, dual signalings from PAMPs and DAMPs generate and secrete IL-1b(beta) and IL-18 resulting self-defensive inflammation and hemostatic reaction. However excessive this dual signaling often reads to systemic and/or fulminant inflammation and coagulation resulting systemic inflammatory response syndrome(SIRS) and/or disseminated intravascular coagulation(DIC). We could present that for example HMGB1 and LPS or thrombin may have a crucial role in these severe conditions. Thus the regulation and intervention of PAMPs and DAMPs are important in preventive medicine in the emergency medicines.

  • Research Products

    (20 results)

All 2014 2013 2012 2011

All Journal Article (18 results) (of which Peer Reviewed: 17 results) Presentation (2 results)

  • [Journal Article] Comparative evaluation of direct thrombin and factor Xa inhibitors with antiplatelet agents under flow and static conditions : an in vitro flow chamber model2014

    • Author(s)
      Hosokawa K, Ohnishi T, Sameshima H, Miura N, Koide T, Maruyama I, Tanaka KA
    • Journal Title

      PLoS One

      Volume: 9(1) Pages: e86491

    • DOI

      10.1371/journal.pone.0086491

    • Peer Reviewed
  • [Journal Article] Antithrombotic effects of PAR1 and PAR4 antagonists evaluated under flow and static conditions2014

    • Author(s)
      Hosokawa K, Ohnishi T, Miura N, Sameshima H, Koide T, Tanaka KA, Maruyama I
    • Journal Title

      Thromb Res

      Volume: 133(1) Pages: 66-72

    • DOI

      10.1016/j.thromres.2013.10.037

    • Peer Reviewed
  • [Journal Article] Hemoadsorption of high-mobility group box chromosomal protein 1 using a column for large animals2013

    • Author(s)
      Nishiyama R, Shinoda M, Tanabe M, Oshima G, Takano K, Miyasho T, Fuchimoto Y, Yamada S, Inoue T, Shimada K, Suda K, Tanaka M, Hayashida T, Yagi H, Kitago M, Obara H, Itano O, Takeuchi H, Kawachi S, Maruyama I, Kitagawa Y
    • Journal Title

      Eur Surg Res

      Volume: 51(3-4) Pages: 181-90

    • DOI

      10.1159/000357563

    • Peer Reviewed
  • [Journal Article] Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism2013

    • Author(s)
      Nakahara M, Ito T, Kawahara K, Yamamoto M, Nagasato T, Shrestha B, Yamada S, Miyauchi T, Higuchi K, Takenaka T, Yasuda T, Matsunaga A, Kakihana Y, Hashiguchi T, Kanmura Y, Maruyama I
    • Journal Title

      PLoS One

      Volume: 8(9) Pages: e75961

    • DOI

      10.1371/journal.pone.0075961

    • Peer Reviewed
  • [Journal Article] Coagulation activity and white thrombus formation in the microminipig2013

    • Author(s)
      Miura N, Kawaguchi H, Nagasato T, Yamada T, Ito T, Izumi H, Sameshima H, Miyoshi N, Tanimoto A, Maruyama I
    • Journal Title

      In Vivo

      Volume: 27(3) Pages: 357-61

    • Peer Reviewed
  • [Journal Article] Analysing responses to aspirin and clopidogrel by measuring platelet thrombus formation under arterial flow conditions2013

    • Author(s)
      Hosokawa K, Ohnishi T, Sameshima H, Miura N, Ito T, Koide T, Maruyama I
    • Journal Title

      Thromb Haemost

      Volume: 109(1) Pages: 102-11

    • DOI

      10.1160/TH12-06-0441

    • Peer Reviewed
  • [Journal Article] Neutrophil elastase inhibitor improves survival rate after ischemia reperfusion injury caused by supravisceral aortic clamping in rats2013

    • Author(s)
      Fujimura N, Obara H, Suda K, Takeuchi H, Miyasho T, Kawasako K, Du W, Yamada S, Ono S, Matsumoto K, Matsuda S, Yagi H, Kitago M, Shinoda M, Itano O, Tanabe M, Sakamoto M, Maruyama I, Kitagawa Y
    • Journal Title

      J Surg Res

      Volume: 180(1) Pages: e31-6

    • DOI

      10.1016/j.jss.2012.04.037

    • Peer Reviewed
  • [Journal Article] Immunohistochemical expression of thrombomodulin in vestibular schwannoma2013

    • Author(s)
      Yamahata H, Yunoue S, Tokimura H, Hanaya R, Hirano H, Tokudome M, Karki P, Yonezawa H, Sugata S, Kawahara K, Maruyama I, Arita K
    • Journal Title

      Brain Tumor Pathol

      Volume: 30(1) Pages: 28-33

    • DOI

      10.1007/s10014-012-0095-z

    • Peer Reviewed
  • [Journal Article] Paucity of CD34-positive cells and increased expression of high-mobility group box 1 in coronary thrombus with type 2 diabetes mellitus2012

    • Author(s)
      Yamashita A, Nishihira K, Matsuura Y, Ito T, Kawahara K, Hatakeyama K, Hashiguchi T, Maruyama I, Yagi H, Matsumoto M, Fujimura Y, Kitamura K, Shibata Y, Asada Y
    • Journal Title

      Atherosclerosis

      Volume: 224(2) Pages: 511-4

    • DOI

      10.1016/j.atherosclerosis.2012.07.027

    • Peer Reviewed
  • [Journal Article] Increased plasma levels of high mobility group box 1 in patients with acute liver failure2012

    • Author(s)
      Oshima G, Shinoda M, Tanabe M, Ebinuma H, Nishiyama R, Takano K, Yamada S, Miyasho T, Masugi Y, Matsuda S, Suda K, Fukunaga K, Matsubara K, Hibi T, Yagi H, Hayashida T, Yamagishi Y, Obara H, Itano O, Takeuchi H, Kawachi S, Saito H, Hibi T, Maruyama I, Kitagawa Y
    • Journal Title

      Eur Surg Res

      Volume: 48(3) Pages: 154-62

    • DOI

      10.1159/000338363

    • Peer Reviewed
  • [Journal Article] Role of high mobility group box chromosomal protein 1 in ischemia-reperfusion injury in the rat small intestine2012

    • Author(s)
      Kojima M, Tanabe M, Shinoda M, Yamada S, Miyasho T, Suda K, Hibi T, Obara H, Itano O, Kawachi S, Kitajima M, Maruyama I, Kitagawa Y
    • Journal Title

      J Surg Res

      Volume: 178(1) Pages: 466-71

    • DOI

      10.1016/j.jss.2012.01.044

    • Peer Reviewed
  • [Journal Article] Circulating high-mobility group box 1 and cardiovascular mortality in unstable angina and non-ST-segment elevation myocardial infarction2012

    • Author(s)
      Hashimoto T, Ishii J, Kitagawa F, Yamada S, Hattori K, Okumura M, Naruse H, Motoyama S, Matsui S, Tanaka I, Izawa H, Maruyama I, Nomura M, Ozaki Y
    • Journal Title

      Atherosclerosis

      Volume: 221(2) Pages: 490-5

    • DOI

      10.1016/j.atherosclerosis.2012.01.040

    • Peer Reviewed
  • [Journal Article] Prediction of the neurological outcome with intrathecal high mobility group box 1 and S100B in cardiac arrest victims : a pilot study2012

    • Author(s)
      Oda Y, Tsuruta R, Fujita M, Kaneda K, Kawamura Y, Izumi T, Kasaoka S, Maruyama I, Maekawa T
    • Journal Title

      Resuscitation

      Volume: 83(8) Pages: 1006-12

    • DOI

      10.1016/j.resuscitation.2012.01.030

    • Peer Reviewed
  • [Journal Article] Mitigation of occult lung injury by pneumonectomy via minithoracotomy in mice2012

    • Author(s)
      Kohno M, Watanabe M, Izumi Y, Tasaka S, Kitagawa Y, Maruyama I, Kobayashi K
    • Journal Title

      Thorac Cardiovasc Surg

      Volume: 60(2) Pages: 124-30

    • DOI

      10.1055/s-0030-1271011

    • Peer Reviewed
  • [Journal Article] 新規DIC 治療薬トロンボモジュリン製剤の作用機序2011

    • Author(s)
      伊藤隆史, 丸山征郎
    • Journal Title

      臨床血液

      Volume: 52巻 Pages: 356-360

  • [Journal Article] Gradual increase of high mobility group protein b1 in the lungs after the onset of acute exacerbation of idiopathic pulmonary fibrosis2011

    • Author(s)
      Ebina M, Taniguchi H, Miyasho T, Yamada S, Shibata N, Ohta H, Hisata S, Ohkouchi S, Tamada T, Nishimura H, Ishizaka A, Maruyama I, Okada Y, Takashi K, Nukiwa T
    • Journal Title

      Pulm Med

      Volume: 2011 Pages: 916486

    • DOI

      10.1155/2011/916486

    • Peer Reviewed
  • [Journal Article] Valproic acid increases susceptibility to endotoxin shock through enhanced release of high-mobility group box 12011

    • Author(s)
      Sugiura S, Ishihara Y, Komatsu T, Hagiwara M, Tanigawa N, Kato Y, Mizutani H, Kawahara K, Maruyama I, Noguchi T, Matsushita K
    • Journal Title

      Shock

      Volume: 36(5) Pages: 494-500

    • DOI

      10.1097/SHK.0b013e31822f7e58

    • Peer Reviewed
  • [Journal Article] Thrombomodulin : protectorate God of the vasculature in thrombosis and inflammation2011

    • Author(s)
      Ito T, Maruyama I
    • Journal Title

      J Thromb Haemost

      Volume: Suppl 1 Pages: 168-73

    • DOI

      10.1111/j.1538-7836.2011.04319.x

    • Peer Reviewed
  • [Presentation] Regulation of Danger Signals from HMGB1and Histones by Endothelial or Circulating Thrombomodulin2013

    • Author(s)
      Ikuro Maruyama
    • Organizer
      The Merinoff World Congress 2013 : HMGB1
    • Place of Presentation
      Manhasset, NY
    • Year and Date
      20131009-11
  • [Presentation] Assay method of des-HMGB1, N-terminus cleaved out HMGB1 by thrombinthrombomodulin, and its clinical significance2013

    • Author(s)
      Ikuro Maruyama, Takashi Ito, Yoshio Azuma, Mayumi Nakahara, Teruto Hashiguchi, Shingo Yamada
    • Organizer
      XXIVcongress of the ISTH
    • Place of Presentation
      Amsterdam, The Netherlands
    • Year and Date
      20130629-0704

URL: 

Published: 2015-06-25  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi