2013 Fiscal Year Final Research Report
Regulatory mechanisms of bone metabolism by innate immune system
| Project/Area Number |
23390426
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAMIJO Ryutaro 昭和大学, 歯学部, 教授 (70233939)
TAMURA Tomohiko 横浜市立大学, 医学系研究科, 教授 (50285144)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 自然免疫 / 骨代謝 / 骨粗鬆症 / 細胞分化 / 破骨細胞 / 骨 / 歯周病 / 薬物 |
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| Research Abstract |
Activation of Toll-like receptors (TLRs) is thought to exacerbate inflammatory bone resorption. In the present study, we found that Poly(I:C), a synthetic double-stranded RNA (dsRNA) that acts as a ligand of Toll-like receptor 3 (TLR3), suppresses bone loss in osteoporosis model mice, while it inhibited osteoclastogenesis via production of interferon (IFN)-beta and the STAT1- dependent signaling pathway in osteoclast precursors. Thus, Poly(I:C) and TLR3 may be important components of a new therapeutic strategy for inflammatory bone loss.
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[Journal Article] Octacalcium phosphate suppresses chondrogenic differentiation of ATDC5 cells2013
Author(s)
Shibuya I, Yoshimura K, Miyamoto Y, Yamada A, Takami M, Suzawa T, Suzuki D, Ikumi N, Hiura F, Anada T, Suzuki O, Kamijo R
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Journal Title
Cell Tissue Res
Volume: Vol.352
Pages: 401-412
DOI
Peer Reviewed
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[Journal Article] Downregulation of carbonic anhydrase IX promotes Col10a1 expression in chondrocytes2013
Author(s)
Maruyama T, Miyamoto Y, Yamamoto G, Yamada A, Yoshimura K, Suzawa T, Takami M, Akiyama T, Hoshino M, Iwasa F, Ikumi N, Tachikawa T, Mishima K, Baba K, Kamijo R
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Journal Title
PLoS ONE
Volume: Vol.8
Pages: e56984
DOI
Peer Reviewed
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[Journal Article] R848, a toll-like receptor 7 agonist, inhibits osteoclast differentiation but not survival or bone-resorbing function of mature osteoclasts2012
Author(s)
Miyamoto A, Takami M, Matsumoto A, Mochizuki A, Yamada T, Tachi K, Shibuya I, Nakamach, T, Shioda S, Baba K, Inoue T, Miyamoto Y, Yim M, Kamijo R
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Journal Title
Cytotechnology
Volume: 64
Pages: 331-339
DOI
Peer Reviewed
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[Journal Article] BMP2 differentially regulates the expression of Gremlin1 and Gremlin2, the negative regulators of BMP function, during osteoblast differentiation2012
Author(s)
Suzuki D, Yamada A, Aizawa R, Funato S, Matsumoto T, Suzuki W, Takami M, Miyamoto Y, Suzawa T, Yamamoto M, Baba K, Kamijo R
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Journal Title
Calcif Tissue Int
Volume: 91
Pages: 88-96
DOI
Peer Reviewed
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[Journal Article] Shared and distinct functions of the transcription factors IRF4 and IRF8 in myeloid cell development2011
Author(s)
Yamamoto M, Kato T, Hotta C, Nishiyama A, Kurotaki D, Yoshinari M, Takami M, Ichino M, Nakazawa M, Matsuyama T, Kamijo R, Kitagawa S, Ozato K, Tamua T
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Journal Title
PLoS ONE
Volume: 6(10)
Pages: e25812
DOI
Peer Reviewed
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[Book] Functions of Toll-like receptors in osteoclast differentiation induced by receptor activator of NF-κB ligand. In The New Frontiers in Research for Oral Cancer2013
Author(s)
Takami M, Miyamoto Y, Matsumoto A, Mochizuki A, Tachi K, Baba K, Inoue T, Mijung Y, Shibuya I, Zhao B, Kamijo R
Total Pages
209(35-49)
Publisher
MARUZEN. CO. LTD, Tokyo
URL
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[Book] Screening for regulators of osteoblast differentiation induced by BMP-2. The New Frontiers in Research for Oral Cancer2013
Author(s)
Yamada A, Matsumoto T, Suzuki D, Funato S, Takami M, Aizawa R, Suzawa T, Miyamoto Y, Suzuki W, Yoshimura K, Nakayama M, Maki K, Yamamoto M, Baba K, Kamijo R
Total Pages
209(82-89)
Publisher
MARUZEN. CO. LTD, Tokyo
URL
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