2014 Fiscal Year Final Research Report
Verification study of sleep bruxism pathogenesis focused on the serotonin nerve activities as neuromodulator
| Project/Area Number |
23390442
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Prosthodontics/ Dental materials science and
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KUBOKI Takuo 岡山大学, 大学院医歯薬学総合研究科, 教授 (00225195)
SOGAWA Chiharu 岡山大学, 大学院医歯薬学総合研究科, 助教 (10253022)
MAEKAWA Kenji 岡山大学, 大学院医歯薬学総合研究科, 准教授 (20304313)
SOGAWA Norio 松本歯科大学, 歯学部, 教授 (30236153)
KITAYAMA Shigeo 岡山大学, 大学院医歯薬学総合研究科, 教授 (80177873)
|
|---|
| Project Period (FY) |
2011-04-01 – 2015-03-31
|
| Keywords | 睡眠時ブラキシズム / セロトニン神経系 / トランスポーター / 筋電図 / 睡眠障害 / 口腔運動器疾患 |
|---|
| Outline of Final Research Achievements |
This aimed to evaluate the correlation between SERT uptake ability in human peripheral platelets and SB frequency. Subjects were consecutively recruited from sixth-year students. SB frequency was determined as the summary score of 3-consecutive night assessments using a self-contained EMG detector/analyzer in their home environment. Fasting peripheral venous blood samples were collected in the morning following the final SB assessment. Amount of SERTs and platelets were quantified by ELISA assay. Functional characterization of SERT, 5-HT uptake, maximum velocity (Vmax) and affinity constant (Km) were assessed by [3H] 5-HT uptake assay. The correlation between these aforementioned variables and SB level was evaluated.
A small but significant negative correlation between SB level and [3H] 5-HT uptake was observed (p<0.05, R2=0.063, Spearman correlation). Platelet serotonin uptake is significantly correlated to SB frequency, although it only explains a small amount of SB variability.
|
| Free Research Field |
歯科補綴学
|
