2013 Fiscal Year Final Research Report
Molecular analysis of inflammasome in periodontal tissue destruction and regeneration.
| Project/Area Number |
23390478
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
YAMADA SATORU 大阪大学, 歯学部附属病院, 講師 (40359849)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Shinya 大阪大学, 大学院・歯学研究科, 教授 (70239490)
KITAMURA Masahiro 大阪大学, 大学院・歯学研究科, 准教授 (10243247)
YANAGITA Manabu 大阪大学, 大学院・歯学研究科, 助教 (80379081)
SAITO Masahiro 東北大学, 大学院・歯学研究科, 教授 (40215562)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO Teruko 東北大学, 大学院・歯学研究科, 教授 (00127250)
MORISAKI Takayuki 国立循環器病研究センター, 分子生物学部, 部長 (30174410)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 歯周組織 / インフラマソーム / ECM分子 |
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| Research Abstract |
In this study, we investigated expression pattern of inflammasome in periodontal tissue and cells to assess the involvement of inflammasome in periodontal tissue homeostasis, destruction and regeneration. It was shown that inflammasome-associated molecules are expressed in periodontal tissues and cells in normal conditions and these expressions are up-regulated in inflammatory conditions. Periodontal ligament associated extracellular matrix (PDL-ECM) proteins show the interaction with inflammasome, suggesting the regulation of tissue-homeostasis and inflammatory responses by PDL-ECM-inflammasome pathway.
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