Epidemiological study to clarify the mechanism of radiation induced thyroid cancer around Chernobyl

2013 Fiscal Year Final Research Report

• Project/Area Number: 23406020
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Hygiene
• Research Institution: Nagasaki University
• Principal Investigator: TAKAMURA Noboru 長崎大学, 原爆後障害医療研究所, 教授 (30295068)
• Co-Investigator(Kenkyū-buntansha): HAYASHIDA Naomi 長崎大学, 原爆後障害医療研究所, 講師 (00420638) ; MATSUDA Naoki 長崎大学, 先導生命科学研究支援センター, 教授 (00304973) ; NAKASHIMA Masahiro 長崎大学, 原爆後障害医療研究所, 講師 (50284683)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Keywords: 甲状腺がん / 放射線 / 内部被ばく

Research Abstract

After the accident at the Chernobyl Nuclear Power Plant (CNPP), the incidence of thyroid cancer increased among children. To assess the prognosis of benign thyroid nodules in individuals living around the CNPP, we conducted a follow-up investigation of screening data from 1991 to 2000 in the Ukraine. Participants of this study were 160 inhabitants with thyroid nodules (nodule group) and 160 inhabitants without thyroid nodules (normal control group) intially identified by ultrasonography from 1991 to 2000.
No thyroid nodules were observed among the normal control group participants. The prevalence of thyroid abnormality, especially nodules that could be cancerous (malignant or suspicious by fine needle aspiration biopsy), was 7.5% in the nodule group and 0% in the normal control group (P<0.001). Our study indicated that a thyroid nodule in childhood is a prognostic factor around Chernobyl.

Research Products

• [Journal Article] Thyroid ultrasound findings in children from three Japanese prefectures : Aomori, Yamanashi and Nagasaki (2013)
  • Author(s): Hayashida N, Imaizumi M, Shimura H, Okubo N, Asari Y, Nigawara T, Midorikawa S, Kotani K, Nakaji S, Otsuru A, Akamizu T, Kitaoka M, Suzuki S, Taniguchi N, Yamashita S, Takamura N
  • Journal Title: PLoS ONE Volume: 8(12) Pages: e83220
  • Peer Reviewed
• [Journal Article] Mental health status among younger generation around Chernobyl (2013)
  • Author(s): Masunaga T, Kozlovsky A, Lyzikov A, Takamura N, Yamashita S
  • Journal Title: Arch Med Sci Volume: 9(6) Pages: 1114-6
  • Peer Reviewed
• [Journal Article] Measurements of individual radiation doses in residents living around the Fukushima Nuclear Power Plant (2013)
  • Author(s): Nagataki S, Takamura N, Kamiya K, Akashi M
  • Journal Title: Rad Res Volume: 180(5) Pages: 439-47
  • Peer Reviewed
• [Journal Article] Determinants for the return to hometowns after the accident at Fukushima Dai-ichi Nuclear Power Plant : a case study for the village of Kawauchi (2013)
  • Author(s): Orita M, Hayashida N, Urata H, Shinkawa T, Endo Y, Takamura N
  • Journal Title: Radiat Prot Dosimetry Volume: 156(3) Pages: 383-5
  • Peer Reviewed
• [Journal Article] Factors associated with relapse into drug use among male and female attendees of a three-month drug detoxification-rehabilitation programme in Dhaka, Bangladesh : a prospective cohort study (2013)
  • Author(s): Maehira Y, Chowdhury EI, Reza M, Drahozal R, Gayen TK, Masud I, Afrin S, Takamura N, Azim T
  • Journal Title: Harm Reduct J Volume: 10(1) Pages: 14
  • Peer Reviewed
• [Journal Article] Genetic profile and determinants of homocysteine levels in Kazakhstan patients with breast cancer (2013)
  • Author(s): Akilzhanova A, Nurkina Z, Momynaliev K, Ramanculov E, Zhumadilov Z, Rakhypbekov T, Hayashida N, Nakashima M, Takamura N
  • Journal Title: Anticancer Res Volume: 33(9) Pages: 4049-59
  • Peer Reviewed
• [Journal Article] Spatiotemporal characteristics of internal radiation exposure in evacuees and first responders after the radiological accident in Fukushima (2013)
  • Author(s): Morita N, Miura M, Yoshida M, Kumagai A, Ohtsuru A, Usa T, Kudo T, Takamura N, Yamashita S, Matsuda N
  • Journal Title: Rad Res Volume: 180(3) Pages: 299-301
  • Peer Reviewed
• [Journal Article] Ultrasonographic thyroid nodular findings in Japanese children (2013)
  • Author(s): Taniguchi N, Hayashida N, Shimura H, Okubo N, Asari Y, Nigawara T, Midorikawa S, Kotani K, Nakaji S, Imaizumi M, Ohtsuru A, Akamizu T, Kitaoka M, Suzuki S, Yamashita S, Takamura N
  • Journal Title: J Med Ultrasonic Volume: 40(3) Pages: 219-24
  • Peer Reviewed
• [Journal Article] Assessment of internal exposure doses in Fukushima by a whole body counter within one month after the nuclear power plant accident (2013)
  • Author(s): Matsuda N, Kumagai A, Ohtsuru A, Morita N, Miura M, Yoshida M, Kudo T, Takamura N, Yamashita S
  • Journal Title: Rad Res Volume: 179(6) Pages: 663-8
  • Peer Reviewed
• [Journal Article] Simultaneous determination of homocysteine, methionine and cysteine in maternal plasma after delivery by HPLC-fluorescence detection with DBD-F as a label (2013)
  • Author(s): Wada M, Hirose M, Kuroki M, Ikeda R, Sekitani Y, Takamura N, Kuroda N, Nakashima K
  • Journal Title: Biomed Chromat Volume: 27(6) Pages: 708-13
  • Peer Reviewed
• [Journal Article] Determinants of homocysteine concentrations in mother and neonatal girl pairs (2013)
  • Author(s): Sekitani Y, Hayashida N, Ikeoka T, Yoshida A, Nakazato M, Wada M, Fujita A, Matsuo A, Miyamura T, Obama M, Nakashima K, Maeda T, Masuzaki H, Takamura N
  • Journal Title: Clin Chem Lab Med Volume: 51(5) Pages: e89-92
  • Peer Reviewed
• [Journal Article] Urinary iodine concentrations of pregnant women in Zhitomir, Ukraine (2013)
  • Author(s): Sekitani Y, Hayashida N, Takahashi J, Kozlovsky A, Rudnitskiy S, Petrova A, Gutevych O, Chorniy A, Yamashita S, Takamura N
  • Journal Title: Clin Chem Lab Med Volume: 51(4) Pages: 811-6
  • Peer Reviewed
• [Journal Article] Vertical distribution and estimated doses from artificial radionuclides in soil samples around the Chernobyl Nuclear Power Plant and the Semipalatinsk Nuclear Testing Site (2013)
  • Author(s): Taira Y, Hayashida N, Tsuchiya R, Yamaguchi H, Takahashi J, Kazlovsky A, Urazalin M, Rakhypbekov T, Kudo T, Yamashita S, Takamura N
  • Journal Title: PLoS ONE Volume: 8(2) Pages: e57524
  • Peer Reviewed
• [Journal Article] Good stress management capability is associated with lower body mass index and restful sleep in the elderly (2013)
  • Author(s): Teraoka S, Hayashida N, Shinkawa T, Taira Y, Nagai-Sekitani Y, Irie S, Kamasaki T, Nakashima-Hashiguchi, Yoshida K, Orita M, Morishita M, Clancey G, Takamura N
  • Journal Title: Tohoku J Exp Med Volume: 229(1) Pages: 5-10
  • Peer Reviewed
• [Journal Article] Prognosis of thyroid nodules in individuals living in the Zhitomir region of Ukraine (2012)
  • Author(s): Hayashida N, Sekitani Y, Takahashi J, Kozlovsky A, Gutevych O, Saiko A, Nirova N, Petrova A, Rafalskiy R, Chorny S, Daniliuk V, Anami M, Yamashita S, Takamura N
  • Journal Title: PLoS ONE Volume: 7(11) Pages: e50648
  • Peer Reviewed
• [Journal Article] Evaluation of environmental contamination and estimated radiation dose for the return to residents' homes in Kawauchi Village, Fukushima Prefecture (2012)
  • Author(s): Taira Y, Hayashida N, Yamaguchi H, Endo Y, Yamashita S, Takamura N
  • Journal Title: PLoS ONE Volume: 7(9) Pages: e45816
  • Peer Reviewed
• [Journal Article] Environmental contamination and external radiation dose rates from radionuclides released from the Fukushima Nuclear Power Plant (2012)
  • Author(s): Taira Y, Takahashi J, Gutevitc A, Kazlovsky A, Kudo T, Matsuda N, Yamashita S, Takamura N
  • Journal Title: Radiat Prot Dosimetry Volume: 151(3) Pages: 537-45
  • Peer Reviewed
• [Journal Article] Importance of personal dose equivalent evaluation in Fukushima in overcoming social panic (2012)
  • Author(s): Yoshida K, Hashiguchi K, Taira Y, Matsuda N, Yamashita S, Takamura N
  • Journal Title: Radiat Prot Dosimetry Volume: 151(1) Pages: 144-6
  • Peer Reviewed
• [Journal Article] Monitoring the autonomic nervous activity as the objective evaluation of music therapy for severely and multiply disabled children (2012)
  • Author(s): Orita M, Hayashida N, Shinkawa T, Kudo T, Koga M, Togo M, Katayama S, Hiramatsu K, Mori S, Takamura N
  • Journal Title: Tohoku J Exp Med Volume: 227(3) Pages: 185-9
  • Peer Reviewed
• [Journal Article] Lessons from Chernobyl (2011)
  • Author(s): Takamura N, Yamashita S
  • Journal Title: Fukushima J Med Sci Volume: 57(2) Pages: 81-5
• [Journal Article] Leptin is an independent determinant of bone mineral density in men with type 2 diabetes mellitus (2011)
  • Author(s): Vasilkova O, Mikhort T, Sanec I, Sharshakova T, Hayashida N, Takamura N
  • Journal Title: Acta Diabetol Volume: 48(4) Pages: 291-5
  • Peer Reviewed
• [Journal Article] Screening for 137Cs Body Burden due to the Chernobyl Accident in Korosten City, Zhitomir, Ukraine : 1996-2008 (2011)
  • Author(s): Hayashida N, Sekitani Y, Kozlovsky A, Rafalsky R, Gutevich O, Daniliuk V, Yamashita S, Takamura N
  • Journal Title: J Rad Res Volume: 52(5) Pages: 629-33
  • Peer Reviewed
• [Journal Article] Background radiation and individual dosimetry in the costal area of Tamil Nadu, India (2011)
  • Author(s): Matsuda N, Brahmanandhan GM, Yoshida M, Takamura N, Suyama A, Koguchi Y, Juto N, Raj YL, Winsley G, Selvasekarapandian S
  • Journal Title: Radiat Prot Dosimetry Volume: 146(1-3) Pages: 314-7
  • Peer Reviewed
• [Journal Article] Suitability of tartrate-resistant Acid phosphatase type 5b as a screening marker for bone mineral density in community-dwelling elderly individuals (2011)
  • Author(s): Irie S, Hayashida N, Shinkawa T, Taira Y, Sekitani Y, Teraoka S, Hashiguchi K, Yoshida K, Morishita M, Takamura N
  • Journal Title: Tohoku J Exp Med
• [Journal Article] Mutational screening of the BRCA1 gene in sporadic breast cancer in the Kazakhstan population (2011)
  • Author(s): Akilzhanova A, Meirmanov S, Zhunussova T, Nakashima M, Takamura N, Akanov Z, Masadykov A, Sandybaev M, Ramankulov E, Yamashita S, Sekine I
  • Journal Title: Breast J Volume: 17(3) Pages: 328-30
  • Peer Reviewed
• [Journal Article] Prevalence of antithyroid antibodies and thyroid-stimulating hormone concentration in young people (2011)
  • Author(s): Sekitani Y, Hayashida N, Karevskaya IV, Zubareva IA, Kozlovsky A, Yamashita S, Takamura N
  • Journal Title: Clin Chem Lab Med Volume: 49(4) Pages: 747-9
  • Peer Reviewed
• [Journal Article] Testosterone is an independent determinant of bone mineral density in men with type 2 diabetes mellitus (2011)
  • Author(s): Vasilkova O, Mikhort T, Sanec I, Sharshakova T, Hayashida N, Takamura N
  • Journal Title: Clin Chem Lab Med Volume: 49(1) Pages: 99-103
  • Peer Reviewed
• [Journal Article] Current concentration of artificial radionuclides and estimated radiation doses around the Chernobyl Nuclear Power Plant, the Semipalatinsk Nuclear Testing Site, and in Nagasaki (2011)
  • Author(s): Taira Y, Hayashida N, Brahmanandhan GM, Nagayama Y, Yamashita S, Takahashi J, Gutevitc A, Kozlovsky A, Urazalin M, Takamura N
  • Journal Title: J Rad Res Volume: 52(1) Pages: 88-95
  • Peer Reviewed