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2013 Fiscal Year Final Research Report

The eco-epidemiology of forest and zoonotic malaria.

Research Project

  • PDF
Project/Area Number 23406022
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Public health/Health science
Research InstitutionNagasaki University

Principal Investigator

NAKAZAWA Shusuke  長崎大学, 熱帯医学研究所, 助教 (20180268)

Co-Investigator(Kenkyū-buntansha) CULLETON Richard  長崎大学, 熱帯医学研究所, 准教授 (10503782)
MASUDA Gaku  京都大学, 地球環境学堂, 特定研究員 (00455916)
MAENO Yoshimasa  藤田保健衛生大学, 医学部, 准教授 (70131191)
KAWAI Satoru  獨協医科大学, 医学部, 准教授 (70275733)
SATO Megumi  新潟大学, 新潟大学, 助教 (70601813)
KOBAYASHI Shigeo  京都大学, 大学院・アジア・アフリカ地域研究研究科, 教授 (40353685)
KANEKO Osamu  長崎大学, 熱帯医学研究所, 教授 (50325370)
YUMOTO Takakazu  京都大学, 霊長類研究所, 教授 (70192804)
Co-Investigator(Renkei-kenkyūsha) HUFFMAN Michael  京都大学, 霊長類研究所, 准教授 (10335242)
Project Period (FY) 2011-04-01 – 2014-03-31
Keywords森林マラリア / サルマラリア / 森林植生・土地利用 / ヒトの行動 / 野生サルの行動 / 媒介蚊の行動 / マラリア伝播 / 学際的研究
Research Abstract

A monkey malaria parasite Plasmodium knowlesi was found in blood samples collected both from people living in Khanh Phu area, Vietnam and from those living on the border between Quang Tri province, Vietnam and Savannakhet province, Laos. The four monkey malaria species, P. knowlesi, P. inui, P. cynomolgi and P. coatneyi and the three human malarial species, P. falciparum, P. vivax ans P. malariae were detected from salivary glands of Anopheles dirus collected by the human landing catch method in Khanh Phu area. The DNA of P. knowlesi was detected from fecal samples collected from a P. knowlesi infecting experimental macaque monkey and wild monkeys. P. knowlesi gametocytes were produced in the blood of P. knowlesi infecting people. Human malaria transmission was found to be maintained by a specific small groups. Terrain, vegetation, land use, livelihood of residents revealed to be related to the infectious diseases.

  • Research Products

    (26 results)

All 2014 2013 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (17 results) Remarks (2 results)

  • [Journal Article] Clinical Presentation and Laboratory Diagnosis of the First Human Case in a Scottish Traveller2014

    • Author(s)
      Cordina, C., Culleton, R., Jones, B.L., Smith, C., McConnachie, A., Coyne, M and Alexander, C.L Plasmodium knowlesi
    • Journal Title

      Journal of Travel Medicine

      Volume: (In Press)

    • DOI

      10.1111/jtm.12131

    • Peer Reviewed
  • [Journal Article] DNA from Pre-Erythrocytic Stage Malaria Parasites is Detectable by PCR in the Faeces and Blood of Hosts2014

    • Author(s)
      Abkallo HM, Liu W, Hokama S, Ferreira PE, Nakazawa S, Maeno, Y., Quang, N. T., Kaneko, O., Huffman, M.A., Kawai, S., Marchand, R. P., Carter, R., B.H., Hahn and Culleton, R
    • Journal Title

      International Journal For Parasitology

      Volume: (In Press)

    • DOI

      10.1016/j.ijpara.2014.03.002

    • Peer Reviewed
  • [Journal Article] Plasmodium genetic loci linked to host cytokine and chemokine responses2014

    • Author(s)
      Pattararadilokrat S, Li J, Wu J, Qi Y, Eastman RT, Zi;versmit M, Nair SC, Huaman MC, Qunones M, Jiang H, Li N, Zhu J, Zhao K, Kaneko O, Long CA, Su XZ
    • Journal Title

      Genes Immun

      Volume: 15 Pages: 145-52

    • Peer Reviewed
  • [Journal Article] Generation of rodent malaria parasites with a high mutation rate by destructing proofreading activity of DNA polymerase δ2014

    • Author(s)
      Honma H, Hirai M, Nakamura S, Hakimi H, Kawazu SI, Palacpac NM, Hisaeda H, Matsuoka H, Kawai S, Endo H, Yasunaga T, Ohashi J, Mita T, Horii T, Furusawa M, TanabeK
    • Journal Title

      DNA Res

      Volume: (In press)

    • Peer Reviewed
  • [Journal Article] African origin of the malaria parasite Plasmodium vivax2014

    • Author(s)
      Li W, Li Y, Shaw KS, Learn GH, Plenderleith LJ, Malenke JA, Sundraraman SA, Ramirez MA, Crystal PA Smith AG, Bibollet-Ruche F, Ayouba A, Locatelli S, Esteben A, Mouacha F, Guichet E, Butel C, Ahuka-Mundeke S, Inogwabini BI, Ndjango JB, Speede S, Sanz CM, Morgan DB, Gonder Mk, Kranzusch PJ, Walsh CM, Morgan DB, Gonder MK, Iranzusch PJ, Walsh PD, Georgiev AV, Muller MN, Piel AK, Stewart FA, Wilson ML, Pusey AE, Cui L, Wang Z, Farnert A, Sutherland CJ, Nolder D, Hart JA, Hart TB, Bertolani P, Gillis A, Lebreton M, Tafon B, Kiyang J, Djolo CF, Schneider BS, Wolfe ND, Mpoudi-Ngole E, Delaporte E, Carter R, Culleton R, Shaw GM, Rayner JC, Peeters M, Han BH, Sharp PM
    • Journal Title

      Nature communications

      Volume: 5 Pages: 346

    • Peer Reviewed
  • [Journal Article] Defining the geographical range of the Plasmodium Knowlesi reservoir2014

    • Author(s)
      Moyes CL, Henry Aj, Golding N, Huang Z, Singh B, Baird JK, Newton PN, Huffman M, Duda KA, Drakely CJ, Elyazar IR, Anstey NM, Chen Q, Zommers Z, Bhatt S, Gething PW, Hay SI
    • Journal Title

      PLoS Negl Trop Dis

      Volume: 8 Pages: e2780

    • DOI

      10.1371/journal.pntd.0002780

    • Peer Reviewed
  • [Journal Article] Genetic diversity and lack of artemisinin selection signature on the Plasmodium falciparum ATP6 in the Greater Mekong Subregion2013

    • Author(s)
      Miao M, Wang Z, Yang Z, Yuan L, Parker DM, PutaporntipC, Jonguwuiwes S, Xangsayarath P, Pngvongsa T, Moji H, Dinh Thuong T, Abe T, Nakazawa S, Kyaw MP, Yan G, Sirichaisinthop J, Sattabongkot J, Mui J, Su XZ, Kaneko O, Gui L
    • Journal Title

      PLoS One

      Volume: 8 Pages: e59192

    • DOI

      10.1371/journal.pone.0059192

    • Peer Reviewed
  • [Presentation] ベトナム南部におけるスポロゾイトから見た森林マラリア伝播の分子疫学的医研究2014

    • Author(s)
      前野芳正, 他
    • Organizer
      第83会日本寄生虫学会大会
    • Place of Presentation
      松山 日本
    • Year and Date
      2014-03-27
  • [Presentation] DAN from pre-erythrocytic patrasites is detected by PCR in the blood and faeces of hosts2013

    • Author(s)
      Culleton R
    • Organizer
      The 4th International Symposium on Human and Monkey malaria in Vietnam
    • Place of Presentation
      Nagasaki Japan
    • Year and Date
      2013-11-27
  • [Presentation] Current status of Plasmodium knowlesi culture in our laboratory2013

    • Author(s)
      Azuma L
    • Organizer
      The 4th International Symposium on Human and Monkey malaria in Vietnam
    • Place of Presentation
      Nagasaki Japan
    • Year and Date
      2013-11-27
  • [Presentation] Anti-malaria antiv bodies in urine : an indicator of malaria burden2013

    • Author(s)
      Itoh M
    • Organizer
      The 4th International Symposium on Human and Monkey malaria in Vietnam
    • Place of Presentation
      Nagasaki Japan
    • Year and Date
      2013-11-27
  • [Presentation] Sero-epidemiological survey of border malaria in Quang Tri, Vietnam2013

    • Author(s)
      Watanabe H
    • Organizer
      The 4th International Symposium on Human and Monkey malaria in Vietnam
    • Place of Presentation
      Nagasaki Japan
    • Year and Date
      2013-11-27
  • [Presentation] Scientific Platform program and Net work2013

    • Author(s)
      Nakazawa S
    • Organizer
      The 4th International Symposium on Human and Monkey malaria in Vietnam
    • Place of Presentation
      Nagasaki Japan
    • Year and Date
      2013-11-26
  • [Presentation] Tropical forest condition related with villagers' livelihoods and infectious diseases in Khanh Phu, Vietnam2013

    • Author(s)
      Kobayashi S.
    • Organizer
      The 4th International Symposium on Human and Monkey malaria in Vietnam
    • Place of Presentation
      Nagasaki Japan
    • Year and Date
      2013-11-26
  • [Presentation] Immigration policy in Vietnam's : central highlands and malaria: memory on epidemic of "immigration malaria" of the Trin's community in Cau Ba and Khanh Phucommunes2013

    • Author(s)
      Shine T
    • Organizer
      The 4th International Symposium on Human and Monkey malaria in Vietnam
    • Place of Presentation
      Nagasaki Japan
    • Year and Date
      2013-11-26
  • [Presentation] What monkeys? : identifying the Khanh Phu P. knowlesi monkey hosts in their own back yard2013

    • Author(s)
      Huffman M
    • Organizer
      The 4th International Symposium on Human and Monkey malaria in Vietnam
    • Place of Presentation
      Nagasaki Japan
    • Year and Date
      2013-11-26
  • [Presentation] Attempts to catch Anopheles dirus with new, human odour-baited traps in Khanh Phu forest2013

    • Author(s)
      Nguyen TQ
    • Organizer
      The 4th International Symposium on Human and Monkey malaria in Vietnam
    • Place of Presentation
      Nagasaki Japan
    • Year and Date
      2013-11-26
  • [Presentation] Micro climatological baseline data of Khanh Phu forest2013

    • Author(s)
      Masuda G
    • Organizer
      The 4th International Symposium on Human and Monkey malaria in Vietnam
    • Place of Presentation
      Nagasaki Japan
    • Year and Date
      2013-11-26
  • [Presentation] Providing useful analyses to the malaria affected areas : a new type of cooperation2013

    • Author(s)
      Masuda G
    • Organizer
      The 4th International Symposium on Human and Monkey malaria in Vietnam
    • Place of Presentation
      Nagasaki Japan
    • Year and Date
      2013-11-26
  • [Presentation] Molecular epidemiological study on gametocyte for the transmission2013

    • Author(s)
      Maeno Y
    • Organizer
      The 4th International Symposium on Human and Monkey malaria in Vietnam
    • Place of Presentation
      Nagasaki Japan
    • Year and Date
      2013-11-26
  • [Presentation] Survey of Plasmodium knowlesi infection in Khanh Phu : detection of the parasites DNA in the blood samples collected from monkey and human2013

    • Author(s)
      Kawai S
    • Organizer
      The 4th International Symposium on Human and Monkey malaria in Vietnam
    • Place of Presentation
      Nagasaki Japan
    • Year and Date
      2013-11-26
  • [Presentation] Plasmodium knowlesi DNA detection in monkey fecal samples2013

    • Author(s)
      Sato M
    • Organizer
      The 4th International Symposium on Human and Monkey malaria in Vietnam
    • Place of Presentation
      Nagasaki Japan
    • Year and Date
      2013-11-26
  • [Presentation] Human behavior: bio-logging people : by changing a lifestyle habit2013

    • Author(s)
      Shine T
    • Organizer
      The 4th International Symposium on Human and Monkey malaria in Vietnam
    • Place of Presentation
      Nagasaki Japan
    • Year and Date
      2013-11-26
  • [Presentation] New perspectives on the transmission of malaria between macaques and humans : the case of Vietnam2013

    • Author(s)
      Huffman M, et al
    • Organizer
      The 5th Congress of European Federation for Primatology
    • Place of Presentation
      Antwerp Belgium
    • Year and Date
      2013-10-10
  • [Remarks]

    • URL

      http://www.tm.nagasaki-u.ac.jp/jsps_aavietnam/index.html

  • [Remarks]

    • URL

      http://www.tm.nagasaki-u.ac.jp/jsps_aavietnam/english/index.html

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Published: 2015-06-25   Modified: 2018-02-26  

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