慢性腎不全の生命予後を規定する遺伝子情報の国際比較調査研究

2013 Fiscal Year Annual Research Report

• Project/Area Number: 23406027
• Section: 海外学術
• Research Institution: Nagoya University
• Principal Investigator: 松尾 清一 名古屋大学, 医学(系)研究科(研究院), 教授 (70190410)
• Co-Investigator(Kenkyū-buntansha): 丸山 彰一 名古屋大学, 医学(系)研究科(研究院), 准教授 (10362253) ; 湯澤 由紀夫 藤田保健衛生大学, 医学部, 教授 (00191479) ; 佐藤 和一 名古屋大学, 医学部附属病院, 講師 (90508920) ; 坪井 直毅 名古屋大学, 医学部附属病院, 講師 (50566958) ; 安田 宜成 名古屋大学, 医学(系)研究科(研究院), 准教授 (60432259) ; 加藤 佐和子 名古屋大学, 医学(系)研究科(研究院), 助教 (80625757)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Keywords: 国際研究者交流 / スウェーデン / ゲノムDNAメチル化 / コホート研究 / LUMA法 / 末期腎不全

Research Abstract

我々は、日本人のCKD stage5患者のコホート研究NISE study (Nagoya Immunity System in the End-stage renal disease study)　を実行中で現在160例近い登録が得られている。初期登録患者50名のゲノムDNAメチル化の解析をLUMA法で行った。患者を高DNAメチル化群と低DNAメチル化群にわけたところ、年齢、性別、糖尿病、喫煙、貧血、血清アルブミン値に違いはなかったが、高DNAメチル化群において有意にフェリチン値が高値であった。また、高メチル化は細菌感染症のマーカーであるプロカルシトニンとフェリチン値に正相関していた。以上のことから、DNAの高メチル化は無症候性の感染症による炎症と関与があることが示唆された（S Kato. Nephron Extra 2012;2:159-168）。また、高メチル化は一年後のCRPの上昇と相関しており、線形回帰モデルによる多変量解析にても、同様の傾向が認められた。以上より高メチル化はそのときの炎症を反映すると共に、将来の炎症にも関与する可能性が示唆された（第２９回国際血液浄化学会にて報告）。
血液浄化療法によってゲノムDNAメチル化が変化するか、またどのような患者がゲノムDNAメチル化の変様を来しやすいか解析するために、透析導入から1年を経過したところで再度約１２０名の血液検体を採取しDNAの抽出を行いストックホルムに郵送した。今後さらに、ストックホルムにてLUMA法で解析を行いゲノムDNAメチル化が患者予後に関与するか検討が必要である。

Current Status of Research Progress

Reason

25年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

25年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Clinical Correlates of Ambulatory BP Monitoring among Patients with CKD. (2013)
  • Author(s): Iimuro S, Imai E, Watanabe T, Nitta K, Akizawa T, Matsuo S, Makino H, Ohashi Y, Hishida A; for the Chronic Kidney Disease Japan Cohort Study Group.
  • Journal Title: Clin J Am Soc Nephrol. Volume: 8(5) Pages: 721-30
  • DOI: 10.2215/CJN.06470612
  • Peer Reviewed
• [Journal Article] Japan Renal Biopsy Registry and Japan Kidney Disease Registry: Committee Report for 2009 and 2010. (2013)
  • Author(s): Sugiyama H, Yokoyama H, Sato H, Saito T, Kohda Y, Nishi S, Tsuruya K, Kiyomoto H, Iida H, Sasaki T, Higuchi M, Hattori M, Oka K, Kagami S, Kawamura T, Takeda T, Hataya H, Fukasawa Y, Fukatsu A, Morozumi K, Yoshikawa N, Shimizu A, Kitamura H, Yuzawa Y, Matsuo S, Kiyohara Y, Joh K, Nagata M, Taguchi T, Makino H
  • Journal Title: Clin Exp Nephrol. Volume: 17(2) Pages: 155-73
  • DOI: 10.1007/s10157-012-0746-8.
  • Peer Reviewed
• [Journal Article] Risk factors for increased left ventricular hypertrophy in patients with chronic kidney disease. (2013)
  • Author(s): Nitta K, Iimuro S, Imai E, Matsuo S, Makino H, Akizawa T, Watanabe T, Ohashi Y, Hishida A.
  • Journal Title: Clin Exp Nephrol. Volume: 17(5) Pages: 730-42
  • DOI: 10.1007/s10157-012-0758-4.
  • Peer Reviewed
• [Journal Article] Deficiency of growth factor midkine exacerbates necrotizing glomerular injuries in progressive glomerulonephritis. (2013)
  • Author(s): Kojima H, Kosugi T, Sato W, Sato Y, Maeda K, Kato N, Kato K, Inaba S, Ishimoto T, Tsuboi N, Matsuo S, Maruyama S, Yuzawa Y, Kadomatsu K.
  • Journal Title: Am J Pathol Volume: 182(2) Pages: 410-9
  • DOI: 10.1016/j.ajpath.2012.10.016.
  • Peer Reviewed
• [Journal Article] Association of cardiac valvular calcifications and C-reactive protein with cardiovascular mortality in incident hemodialysis patients: a Japanese cohort study. (2013)
  • Author(s): Takahashi H, Ishii H, Aoyama T, Kamoi D, Kasuga H, Ito Y, Yasuda K, Tanaka M, Yoshikawa D, Maruyama S, Matsuo S, Murohara T, Yuzawa Y.
  • Journal Title: Am J Kidney Dis Volume: 61(2) Pages: 254-61
  • DOI: 10.1053/j.ajkd.2012.09.007.
  • Peer Reviewed
• [Journal Article] Serum-Starved Adipose-Derived Stromal Cells Ameliorate Crescentic GN by Promoting Immunoregulatory Macrophages. (2013)
  • Author(s): Furuhashi K, Tsuboi N, Shimizu A, Katsuno T, Kim H, Saka Y, Ozaki T, Sado Y, Imai E, Matsuo S, Maruyama S.
  • Journal Title: J Am Soc Nephrol. Volume: 24(4) Pages: 587-603
  • DOI: 10.1681/ASN.2012030264.
  • Peer Reviewed
• [Journal Article] Nationwide survey on current treatments for IgA nephropathy in Japan. (2013)
  • Author(s): Matsuzaki K1, Suzuki Y, Nakata J, Sakamoto N, Horikoshi S, Kawamura T, Matsuo S, Tomino Y
  • Journal Title: Clin Exp Nephrol Volume: 17(6) Pages: 827-33
  • DOI: 10.1007/s10157-013-0779-7.
  • Peer Reviewed
• [Journal Article] Overestimation of the risk of progression to end-stage renal disease in the poor prognosis' group according to the 2002 Japanese histological classification for immunoglobulin A nephropathy. (2013)
  • Author(s): Miyazaki Y, Kawamura T, Joh K, Okonogi H, Koike K, Utsunomiya Y, Ogura M, Matsushima M, Yoshimura M, Horikoshi S, Suzuki Y, Furusu A, Yasuda T, Shirai S, Shibata T, Endoh M, Hattori M, Akioka Y, Katafuti R, Hashiguchi A, Kimura K, Matsuo S, Tomino Y.
  • Journal Title: Clin Exp Nephrol. Volume: Epub Pages: Epub
  • Peer Reviewed
• [Journal Article] Proposal of remission criteria for IgA nephropathy. (2013)
  • Author(s): Suzuki Y, Matsuzaki K, Suzuki H, Sakamoto N, Joh K, Kawamura T, Tomino Y, Matsuo S.
  • Journal Title: Clin Exp Nephrol Volume: Epub Pages: Epub
  • Peer Reviewed
• [Journal Article] Anti-C5a complementary peptide ameliorates acute peritoneal injuries induced by neutralization of Crry and CD59. (2013)
  • Author(s): Mizuno T, Mizuno M, Imai M, Suzuki Y, Kushida M, Noda Y, Maruyama S, Okada H, Okada N, Matsuo S, Ito Y.
  • Journal Title: Am J Physiol Renal Physiol. Volume: 305(11) Pages: F1603-16
  • DOI: 10.1152/ajprenal.00681.2012.
  • Peer Reviewed
• [Journal Article] Lower serum albumin level is associated with higher fractional excretion of creatinine. (2013)
  • Author(s): Horio M, Imai E, Yasuda Y, Watanabe T, Matsuo S.
  • Journal Title: Clin Exp Nephrol Volume: Epub Pages: Epub
  • Peer Reviewed
• [Journal Article] Perforative peritonitis caused by appendicitis in a patient on peritoneal dialysis. (2013)
  • Author(s): Mizuno M, Suzuki Y, Nonaka K, Sei Y, Maruyama S, Matsuo S, Ito Y.
  • Journal Title: Intern Med. Volume: 52(11) Pages: 1177-81
  • Peer Reviewed
• [Journal Article] A ray of light in the dark: alternative approaches to the assessment and treatment of ischemic nephropathy. (2013)
  • Author(s): Tsuboi N, Maruyama S, Matsuo S, Imai E.
  • Journal Title: Nephrol Dial Transplant. Volume: 29(2) Pages: 228-31
  • DOI: 10.1093/ndt/gft463.
  • Peer Reviewed
• [Journal Article] Geriatric nutritional risk index accurately predicts cardiovascular mortality in incident hemodialysis patients. (2013)
  • Author(s): Takahashi H, Ito Y, Ishii H, Aoyama T, Kamoi D, Kasuga H, Yasuda K, Maruyama S, Matsuo S, Murohara T, Yuzawa Y.
  • Journal Title: J Cardiol. Volume: S0914-5087(13) Pages: 00352-3
  • DOI: 10.1016/j.jjcc.2013.10.018.
  • Peer Reviewed
• [Journal Article] Rat adipose tissue-derived stem cells attenuate peritoneal injuries in rat zymosan-induced peritonitis accompanied by complement activation. (2013)
  • Author(s): Kim H, Mizuno M, Furuhashi K, Katsuno T, Ozaki T, Yasuda K, Tsuboi N, Sato W, Suzuki Y, Matsuo S, Ito Y ,Maruyama S1.
  • Journal Title: Cytotherapy. Volume: 16(3) Pages: 357-68
  • DOI: 10.1016/j.jcyt.2013.10.011
  • Peer Reviewed
• [Journal Article] Significance of combined cyclosporine-prednisolone therapy and cyclosporine blood concentration monitoring for idiopathic membranous nephropathy with steroid-resistant nephrotic syndrome: a randomized controlled multicenter trial. (2013)
  • Author(s): Saito T, Iwano M, Matsumoto K, Mitarai T, Yokoyama H, Yorioka N, Nishi S, Yoshimura A, Sato H, Ogahara S, Shuto H, Kataoka Y, Ueda S, Koyama A, Maruyama S, Nangaku M, Imai E, Matsuo S, Tomino Y; The Refractory Nephrotic Syndrome Study Group.
  • Journal Title: Clin Exp Nephrol. Volume: Epub Pages: Epub
  • Peer Reviewed
• [Journal Article] CD147/basigin reflects renal dysfunction in patients with acute kidney injury. (2013)
  • Author(s): Nagaya H, Kosugi T, Maeda-Hori M, Maeda K, Sato Y, Kojima H, Hayashi H, Kato N, Ishimoto T, Sato W, Yuzawa Y, Matsuo S, Kadomatsu K, Maruyama S.
  • Journal Title: Clin Exp Nephrol. Volume: Epub Pages: Epub
  • Peer Reviewed
• [Journal Article] Long-Term Effects of Spironolactone in Peritoneal Dialysis Patients. (2013)
  • Author(s): Ito Y, Mizuno M, Suzuki Y, Tamai H, Hiramatsu T, Ohashi H, Ito I, Kasuga H, Horie M, Maruyama S, Yuzawa Y, Matsubara T, Matsuo S; on behalf of the Nagoya Spiro Study Group.
  • Journal Title: J Am Soc Nephrol. Volume: Epub Pages: Epub
  • Peer Reviewed
• [Journal Article] Comparison of Kidney Disease: Improving Global Outcomes and Acute Kidney Injury Network criteria for assessing patients in intensive care units. (2013)
  • Author(s): Shinjo H, Sato W, Imai E, Kosugi T, Hayashi H, Nishimura K, Nishiwaki K, Yuzawa Y, Matsuo S, Maruyama S.
  • Journal Title: Clin Exp Nephrol Volume: Epub Pages: Epub
  • Peer Reviewed
• [Presentation] Spironolactone improving intrarenal renin-angiotensin system activation in type ２diabetic nephropathy patients with overt albuminuria. (2014)
  • Author(s): Sawako Kato, Shoichi Maruyama, Hirofumi Makino, Jun Wada, Takashi Uzu, Hisazumi Araki,Daisuke Koya, Keizo Kanasaki, Akira Nishiyama, Hiroyuki Kobori, Enyu Imai, Masahiko Ando, Yutaka Oiso, Seiichi Matsuo
  • Organizer: The 14th Asian Pacific Congress of Nephrology
  • Place of Presentation: SHINAGAWA PRINCE HOTEL(東京港区）
  • Year and Date: 20140514-20140514
• [Presentation] ASSOCIATION OF GLOMERULAR MACROPHAGE PHENOTYPES AND URINE SOLUBLE CD163 WITH DISEASE ACTIVITY IN HUMAN LUPUS NEPHRITIS. (2014)
  • Author(s): N. Endo, N. Tsuboi, K. Furuhashi, S. Matsuo, S. Maruyama.
  • Organizer: 9th International Congress on Autoimmunity
  • Place of Presentation: Nice,France
  • Year and Date: 20140326-20140330
• [Presentation] Lower Serum Albumin Level Is Associated with Higher Fractional Excretion of Creatinine. (2013)
  • Author(s): Masaru Horio, MD, Enyu Imai, MD, PhD, Yoshinari Yasuda, MD, PhD, Tsuyoshi Watanabe, MD, Seiichi Matsuo, MD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
  • Year and Date: 20131105-20131110
• [Presentation] Performance of Japanese and CKD-EPI GFR Equations in Japanese Subjects. (2013)
  • Author(s): Yoshinari Yasuda, MD, PhD, Imai Junko, Shoichi Maruyama, MD, Seiichi Matsuo, MD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
  • Year and Date: 20131105-20131110
• [Presentation] Spironolactone Prevents Cardiac Hypertrophy in Peritoneal Dialysis Patients without Significant Adverse Effects. (2013)
  • Author(s): Yasuhiko Ito, MD, PhD, Masashi Mizuno, MD, PhD, Yasuhiro Suzuki, MD, Hirotake Kasuga, MD, PhD, Shoichi Maruyama, MD, Yukio Yuzawa, MD, Seiichi Matsuo, MD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
  • Year and Date: 20131105-20131110
• [Presentation] The Nationwide Retrospective Cohort Study in IgA Nephropathy in Japan. (2013)
  • Author(s): Takashi Yasuda, MD, PhD, Yoshinari Yasuda, MD, PhD, Sachiko Ohde, Osamu Takahashi, MD, PhD, Tetsuya Kawamura, MD, PhD, Seiichi Matsuo, MD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
  • Year and Date: 20131105-20131110
• [Presentation] Adverse Events Associated with Immunosuppressive Therapy and Tonsillectomy in IgAN: The Nationwide Retrospective Cohort Study in IgAN in Japan. (2013)
  • Author(s): Yoshinari Yasuda, MD, PhD, Takashi Yasuda, MD, PhD, Sachiko Ohde, Osamu Takahashi, MD, PhD, Tetsuya Kawamura, MD, PhD, Seiichi Matsuo, MD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
  • Year and Date: 20131105-20131110
• [Presentation] Neutrophil/Lymphocyte Ratio as a Predictor of Cardiovascular Events in Japanese Patients Starting Renal Replacement Therapy. (2013)
  • Author(s): Sawako Kato, MD, PhD, Bengt Lindholm, MD, PhD, Yukio Yuzawa, MD, Seiichi Matsuo, MD, Shoichi Maruyama, MD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
  • Year and Date: 20131105-20131110
• [Presentation] Mac-1 Deficiency Protects Mouse from Pulmonary Hemorrhage, whereas Exacerbates Glomerulonephritis in Experimental Model of Systemic Lupus Erythematosus. (2013)
  • Author(s): Yiqin Shi, Naotake Tsuboi, MD, PhD, Kazuhiro Furuhashi, MD, PhD, Shoichi Maruyama, MD, Seiichi Matsuo, MD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
  • Year and Date: 20131105-20131110
• [Presentation] GFR Distributions among Scheduled Contrast-Enhanced Computed Tomography before and after eGFR Self-Report. (2013)
  • Author(s): Yoshinari Yasuda, MD, PhD, Kanako Shibata, Shoichi Maruyama, MD, Seiichi Matsuo, MD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
  • Year and Date: 20131105-20131110
• [Presentation] Glycosylated Protein CD147 Reflects Renal Dysfunction in Patients with Acute Tubular Necrosis. (2013)
  • Author(s): Hiroshi Kojima, MD, Tomoki Kosugi, MD, PhD, Mayuko Maeda, MD, Kayaho Maeda, MD, Yuka Sato, MD, Hiroki Hayashi, MD, Waichi Sato, MD, PhD, Seiichi Matsuo, MD, Shoichi Maruyama, MD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
  • Year and Date: 20131105-20131110
• [Presentation] C-Reactive Protein Mediates the Association between Low Socioeconomic Status and Pulse Pressure in Japanese CKD Cohort (CKD-JAC). (2013)
  • Author(s): Naohiko Fujii, MD, PhD, Takayuki Hamano, MD, PhD, Yoshitaka Isaka, MD, PhD, Tsuyoshi Watanabe, MD, Kosaku Nitta, MD, PhD, Tadao Akizawa, MD, Seiichi Matsuo, MD, Enyu Imai, MD, PhD, Hirofumi Makino, MD, PhD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
  • Year and Date: 20131105-20131110
• [Presentation] Resistance to Immunosuppressive Therapy in Patients with Primary Nephrotic Syndrome: Japan Nephrotic Syndrome Cohort Study (JNSCS) (2013)
  • Author(s): Ryohei Yamamoto, MD, PhD, Shoichi Maruyama, MD, Hitoshi Yokoyama, MD, PhD, Seiichi Matsuo, MD, Enyu Imai, MD, PhD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
  • Year and Date: 20131105-20131110
• [Presentation] Molecular Characteristics of Anti-PLA2R IgG in Japanese Patients with Idiopathic Membranous Nephropathy. (2013)
  • Author(s): Shin' ichi Akiyama, PhD, Enyu Imai, MD, PhD, Seiichi Matsuo, MD, Shoichi Maruyama, MD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
  • Year and Date: 20131105-20131110
• [Presentation] Regional Differences in Chronic Kidney Disease Prevalence in Japan: A Japanese Nationwide Health-Check Study. (2013)
  • Author(s): Yoshinari Yasuda, MD, PhD, Kiyoshi Shibata, PhD, Kunitoshi Iseki, MD, Toshiki Moriyama, MD, PhD, Kunihiro Yamagata, MD, PhD, Kazuhiko Tsuruya, MD, PhD, Hideaki Yoshida, MD, PhD, Shouichi Fujimoto, MD, Koichi Asahi, MD, PhD, Tsuyoshi Watanabe, MD, Seiichi Matsuo, MD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
  • Year and Date: 20131105-20131110
• [Presentation] Serum-starved Adipose-derived Stromal Cells Ameliorate Rat Crescentic Glomerulonephritis By Promoting Immunoregulatory Macrophages. (2013)
  • Author(s): Naotake Tsuboi, Kazuhiro Furuhashi, Seiichi Matsuo, Shoichi Maruyama
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
  • Year and Date: 20131105-20131110
• [Presentation] SLEに伴うPodocyte infoldingの1例 (2013)
  • Author(s): 田中 章仁、神谷 文隆、永原 靖子、鈴木 康弘、加藤 規利、勝野 敬之、尾崎 武徳、小杉 智規、佐藤 和一、坪井 直毅、水野 正司、丸山 彰一、伊藤 恭彦、松尾 清一
  • Organizer: 第43回日本腎臓学会西部学術大会
  • Place of Presentation: 松山全日空ホテル(愛媛県松山市)
  • Year and Date: 20131011-20131012
• [Presentation] 視力障害で発症し多発性硬化症と診断した腹膜透析患者の一例 (2013)
  • Author(s): 永原 靖子、鈴木 康弘、加藤 規利、勝野 敬之、尾崎 武徳、小杉 智規、佐藤 和一、坪井 直毅、水野 正司、丸山 彰一、伊藤 恭彦、松尾 清一
  • Organizer: 第43回日本腎臓学会西部学術大会
  • Place of Presentation: 松山全日空ホテル(愛媛県松山市)
  • Year and Date: 20131011-20131012
• [Presentation] CKD診療連携における多職種介入の効果 (2013)
  • Author(s): 濱田 昌実、加藤 佐和子、林 睦晴、後藤 資実、安田 宜成、丸山 彰一、松尾 清一
  • Organizer: 第43回日本腎臓学会西部学術大会
  • Place of Presentation: 松山全日空ホテル(愛媛県松山市)
  • Year and Date: 20131011-20131012
• [Presentation] The continuous erythropoietin receptor activator (C.E.R.A.) maintains renal anemia safely at extended administration intervals in CAPD patients. (2013)
  • Author(s): Takako Tomita, Yasuhiro Suzuki, Yasuhiko Ito, Masashi Mizuno, Hiroshi Kinashi, Humiko Sakata, Takeshi Terabayashi, Yumi Sei, Shoichi Maruyama and Seiichi Matsuo
  • Organizer: 6th International Society for Peritoneal Dialysis - Asia Pacific Chapter Meeting, ISPD-APCM
  • Place of Presentation: 台北,中国
  • Year and Date: 20130927-20130929
• [Presentation] Low Serum Cultured Adipose Tissue-derived Stromal Cells Ameriorate Acute Kidney Injury In Rats. (2013)
  • Author(s): Takayuki Katsuno, Naotake Tsuboi, Seiichi Matsuo, Shoichi Maruyama
  • Organizer: Forefronts in Nephrology Florence
  • Place of Presentation: フィレンツェ、イタリア
  • Year and Date: 20130912-20130915
• [Presentation] Expression of membrane complement regulators in end stage renal disease patients on peritoneal dialysis therapy. (2013)
  • Author(s): Yumi Sei, Masashi Mizuno, Yasuhiro Suzuki, Masaki Imai, Keiko Higashide, Claire L Harris, Seiichi Matsuo,Yasuhiko Ito
  • Organizer: 14th European Meeting on Complement in Human Disease
  • Place of Presentation: イエーナ,ドイツ
  • Year and Date: 20130817-20130821
• [Presentation] 脂肪由来間葉系幹細胞を用いた急性呼吸窮迫症候群への治療戦略 (2013)
  • Author(s): 三村哲史，坪井直毅，橋本直純，清水明日花，金恒秀，古橋和拡，松尾清一，丸山彰一
  • Organizer: 第34回日本炎症再生医学会
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 20130702-20130703
• [Presentation] 低血清培養脂肪由来間葉系幹細胞の創傷治癒促進効果についての検討 (2013)
  • Author(s): 阿部 智子，尾崎 武徳，堀之内明日花，金 恒秀，古橋 和拡，秋山 真一，勝野 敬之，安田 香，坪井 直毅，松尾 清一，丸山 彰一
  • Organizer: 第34回日本炎症再生医学会
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 20130702-20130703
• [Presentation] Mac-1 deficiency protects mouse from pulmonary hemorrhage, whereas (2013)
  • Author(s): 石 一沁，坪井 直毅，古橋 和拡，Mayadas Tanya，丸山 彰一，松尾 清一
  • Organizer: 第34回日本炎症再生医学会
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 20130702-20130703
• [Presentation] 保存期腎不全～CKD-JAC主解析結果について～ (2013)
  • Author(s): 今井圓裕、松尾清一、渡辺毅、菱田明
  • Organizer: 第58回日本透析医学会学術集会
  • Place of Presentation: 福岡国際会議場(福岡市)
  • Year and Date: 20130620-20130623
• [Presentation] 名古屋大学関連施設レジストリーからみた現在の腹膜透析の問題点とその対策 (2013)
  • Author(s): 伊藤恭彦、水野正司、鈴木康弘、松尾清一
  • Organizer: 第58回日本透析医学会学術集会
  • Place of Presentation: 福岡国際会議場(福岡市)
  • Year and Date: 20130620-20130623
• [Presentation] 多施設PD合同レジストリーにおける患者予後規定因子の検討 (2013)
  • Author(s): 杉山斉、森永裕士、槇野博史、伊藤恭彦、松尾清一、鶴屋和彦、吉田寿子、丸山弘樹、後藤眞、西野友哉、寺脇博之、中山昌明、中元秀友
  • Organizer: 第58回日本透析医学会学術集会
  • Place of Presentation: 福岡国際会議場(福岡市)
  • Year and Date: 20130620-20130623
• [Presentation] Fabry病による慢性腎不全で長期に安定した腹膜透析(PD)施行中の一例 (2013)
  • Author(s): 武藤玲子、勝野敬之、鈴木康弘、安田香、尾崎武徳、小杉智規、安田宜成、佐藤和一、坪井直毅、水野正司、伊藤恭彦、丸山彰一、松尾清一
  • Organizer: 第58回日本透析医学会学術集会
  • Place of Presentation: 福岡国際会議場(福岡市)
  • Year and Date: 20130620-20130623
• [Presentation] 血友病A,慢性C型肝硬変、HIV三者合併の血液透析導入１症例 (2013)
  • Author(s): 坪井 直毅、武藤玲子、安田香、佐藤和一、丸山彰一、松尾清一
  • Organizer: 第58回日本透析医学会学術集会
  • Place of Presentation: 福岡国際会議場(福岡市)
  • Year and Date: 20130620-20130623
• [Presentation] Serum-starved adipose-derived stromal cells ameliorate rat crescentic glomerulonephritis by promoting immunoregulatory macrophages. (2013)
  • Author(s): Kazuhiro Furuhashi, Naotake Tsuboi, Asuka Shimizu, Yiqin Shi, Hangsoo Kim, Takayuki Katsuno, Yosuke Saka, Takenori Ozaki, Waichi Sato, Enyu Imai, Seiichi Matsuo, Shoichi Maruyama
  • Organizer: ISSCR(International Society for Stem Cell Research) 11th Annual Meeting
  • Place of Presentation: Boston,USA
  • Year and Date: 20130612-20130615
• [Presentation] BENEFICIAL EFFECT OF CONTINUOUS ERYTHROPOIETIN RECEPTOR ACTIVATOR (C.E.R.A.) IN CAPD PATIENTS. (2013)
  • Author(s): Yasuhiro Suzuki, Yasuhiko Ito,Masashi Mizuno,Hideki Hiramatsu,Hiroshi Kinashi, Humiko Nagura, Takeshi Terabayashi, Yumi Sei, Takako Tomita, Shoichi Maruyama,Seiichi Matsuo.
  • Organizer: The World Congress of Nephrology 2013
  • Place of Presentation: 香港(中国）
  • Year and Date: 20130531-20130604
• [Presentation] LOW SERUM CULTURED ADIPOSE-DERIVED MESENCHIMAL STROMAL CELLS AMERIORATE RAT MODEL WITH UNILATERAL URETERAL OBSTRUCTION. (2013)
  • Author(s): Tomoko Abe, Asuka Horinouchi, Hangsoo Kim, Kazuhiro Huruhashi, Shinichi Aiyama, Takayuki Katsuno, Kaoru Yasuda, Takinori Ozaki, Naotake Tsuboi, Seiichi Matsuo, Shouichi Maruyama.
  • Organizer: The World Congress of Nephrology 2013
  • Place of Presentation: 香港(中国）
  • Year and Date: 20130531-20130604
• [Presentation] MIDKINE REGULATES BLOOD PRESSURE THROUGH CYTOCHROME P450-DERIVED EICOSANOIDS. (2013)
  • Author(s): Yuka Sato, Waichi Sato,Shoichi Maruyama, Christpher Wilcox, John Falck, Tomohiro Masuda, Tomoki Kosugi,Enyu Imai, Kenji Kadomatsu, Seiichi Matsuo.
  • Organizer: The World Congress of Nephrology 2013
  • Place of Presentation: 香港(中国）
  • Year and Date: 20130531-20130604
• [Presentation] ANTI-PHOSPHOLIPASE A2 RECEPTOR ANTIBODIES FOR MEMBRANOUS NEPHROPATHY WITH NEPHROTIC SYNDROME IN JAPAN. (2013)
  • Author(s): Reiko Muto, Eri Ito, Shinichi Akiyama, Takenori Ozaki, Sawako Kato, Waichi Sato, Shoichi Maruyama,Seiichi Matsuo.
  • Organizer: The World Congress of Nephrology 2013
  • Place of Presentation: 香港(中国）
  • Year and Date: 20130531-20130604
• [Presentation] SERUM-STARVED ADIPOSE-DERIVED STROMAL CELLS AMELIORATE RENAL INJURY ASSOCIATED WITH RAT CRESCENTIC GLOMERULONEPHRITIS BY PROMOTING THE GENERATION OF IMMUNOREGULATORY MACROPHAGES. (2013)
  • Author(s): Kazuhiro Furuhashi, Naotake Tsuboi, Asuka Shimizu, Hangsoo Kim,Takayuki Katsuno, Seiichi Matsuo, Shoichi Maruyama.
  • Organizer: The World Congress of Nephrology 2013
  • Place of Presentation: 香港(中国）
  • Year and Date: 20130531-20130604
• [Presentation] THE SERUM BETA 2-MICROGLOBULIN LEVEL PREDICTS PATIENT SURVIVAL IN ASSOCIATION WITH THE RESIDUAL RENAL FUNCTION IN JAPANESE PATIENTS ON PERITONEAL DIALYSIS: A PROSPECTIVE MULTICENTER COHORT STUDY (PDR-CS) . (2013)
  • Author(s): Hitoshi Sugiyama, Yasuhiko Ito,Kazuhiko Tsuruya, Hisako Yoshida, Hiroki Maruyama, Shin Goto, Tomoya Nishino, Masaaki Nakayama, Hidetomo Nakamoto, Hiroshi Morinaga, Seiichi Matsuo, Hirofumi Makino.
  • Organizer: The World Congress of Nephrology 2013
  • Place of Presentation: 香港(中国）
  • Year and Date: 20130531-20130604
• [Presentation] EFFICACY AND SAFETY OF FLUOROSCOPIC MANIPULATION USING ALPHA REPLACER FOR PERITONEAL CATHETER MALPOSITION. (2013)
  • Author(s): Yosuke Saka, Keisuke Nonaka, Yuko Shimamura, Akihiro Sawai, Mitsuhiro Tawada, Yasuhiko Ito, Syoichi Maruyama, Seiichi Matsuo.
  • Organizer: The World Congress of Nephrology 2013
  • Place of Presentation: 香港(中国）
  • Year and Date: 20130531-20130604
• [Presentation] RAT ADIPOSE TISSUE-DERIVED STROMAL CELLS ATTENUATE PERITONEAL INJURIES IN RAT ZYMOSAN-INDUCED PERITONITIS ACCOMPANIED BY COMPLEMENT ACTIVATION. (2013)
  • Author(s): Hangsoo Kim,Masashi Mizuno, Kazuhiro Furuhashi,Takayuki Katsuno, Takenori Ozaki,Kaoru Yasuda,1 Naotake Tsuboi, Yasuhiko Ito,Shoichi Maruyama, Matsuo Seiichi.
  • Organizer: The World Congress of Nephrology 2013
  • Place of Presentation: 香港(中国）
  • Year and Date: 20130531-20130604
• [Presentation] RESISTANCE TO IMMUNOSUPPRESSIVE THERAPY IN PRIMARY NEPHROTIC SYNDROME: JAPAN NEPHROTIC SYNDROME COHORT STUDY (JNSCS). (2013)
  • Author(s): Shoichi Maruyama, Ryohei Yamamoto, Hitoshi Yokoyama, Yoshitaka Isaka, Kosaku Nitta,Eri Muso, Shunya Uchida,Kunio Morozumi, Seiichi Matsuo, Enyu Imai.
  • Organizer: The World Congress of Nephrology 2013
  • Place of Presentation: 香港(中国）
  • Year and Date: 20130531-20130604
• [Presentation] PROPOSAL OF CLINICAL REMISSION CRITERIA FOR IgA NEPHROPATHY PATIENTS. (2013)
  • Author(s): Keiichi Matsuzaki,Yusuke Suzuki, Naoko Sakamoto,Hitoshi Suzuki, Hiroyuki Yanagawa,Satoshi Horikoshi,Seiichi Matsuo, Tetsuya Kawamura, Yasuhiko Tomino.
  • Organizer: The World Congress of Nephrology 2013
  • Place of Presentation: 香港(中国）
  • Year and Date: 20130531-20130604
• [Presentation] THE LOWER SOCIOECONOMIC STATUS DOES NOT REPRESENT THE WORSE PHOSPHATE STATUS IN JAPAN, UNLIKE IN THE UNITED STATES. (2013)
  • Author(s): Naohiko Fujii, Takayuki Hamano, Yoshitaka Isaka, Tsuyoshi Watanabe, Yasuo Ohashi, Kosaku Nitta, Tadao Akizawa,Akira Hishida,Seiichi Matsuo,Enyu Imai, Hirofumi Makino.
  • Organizer: The World Congress of Nephrology 2013
  • Place of Presentation: 香港(中国）
  • Year and Date: 20130531-20130604
• [Presentation] PREVALENCE OF AUTOANTIBODY AGAINST PLA2R IN PATIENTS WITH MEMBRANOUS NEPHROPATHY IN JAPAN. (2013)
  • Author(s): Shin'ichi Akiyama,Takenori Ozaki,Hitoshi Yokoyama, Enyu Imai,Seiichi Matsuo,Shoichi Maruyama.
  • Organizer: The World Congress of Nephrology 2013
  • Place of Presentation: 香港(中国）
  • Year and Date: 20130531-20130604
• [Presentation] ＣＤ１４７はループス腎炎の重症度を反映する。 (2013)
  • Author(s): 前田 麻友子、小杉 智規、長屋 啓、前田 佳哉輔、佐藤 由香、小島 博、尾崎 武徳、佐藤 和一、丸山 彰一、松尾 清一
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 20130510-20130512
• [Presentation] 片側尿管結紮モデルラットに対する低血清培養脂肪由来間葉系幹細胞の効果 (2013)
  • Author(s): 阿部 智子、堀之内 明日花、金 恒秀、古橋 和拡、秋山 真一、勝野 敬之、安田 香、尾崎 武徳、坪井 直毅、松尾 清一、丸山 彰一
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 20130510-20130512
• [Presentation] ワークショップ2 基礎から臨床につながる補体学 (2013)
  • Author(s): 水野 正司、伊藤 恭彦、鈴木 康弘、清 祐実、丸山 彰一、松尾 清一
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 20130510-20130512
• [Presentation] Zymosan投与により誘導される補体依存性腹膜炎モデルに対する脂肪由来間葉系幹細胞の有用性 (2013)
  • Author(s): 金 恒秀、水野 正司、古橋 和拡、勝野 敬之、安田 香、尾崎 武徳、坪井 直毅、伊藤 恭彦、松尾 清一、丸山 彰一
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 20130510-20130512
• [Presentation] 腎代替療法における補体の関わり (2013)
  • Author(s): 水野正司、伊藤恭彦、鈴木康弘、清祐実、丸山彰一、松尾清一
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 20130510-20130512
• [Presentation] ミッドカイン（MK）がepoxyeicosatrienoic acids(EETs)を抑制し血圧制御に関与する (2013)
  • Author(s): 佐藤 由香、佐藤 和一、増田 智広、小杉 智規、丸山 彰一、今井 圓裕、松尾 清一
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 20130510-20130512
• [Presentation] 新規透析導入患者における脈圧と平均血圧の検討 (2013)
  • Author(s): 加藤 佐和子、丸山 彰一、安田 宜成、杉浦 祥代、鶴田 良成、湯澤 由紀夫、松尾 清一
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 20130510-20130512
• [Presentation] ミネラロコルチコイド受容体(MR)拮抗薬の腹膜透析患者の心・腹膜・残腎機能への効果 (2013)
  • Author(s): 伊藤 恭彦、水野 正司、玉井 宏史、平松 武幸、大橋 宏重、伊藤 功、春日 弘毅、丸山 彰一、松尾 清一
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 20130510-20130512
• [Presentation] 日本の膜性腎症患者における抗PLA2R自己抗体の陽性率 (2013)
  • Author(s): 秋山 真一、尾崎 武徳、横山 仁、松尾 清一、今井 圓裕、丸山 彰一
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 20130510-20130512
• [Presentation] 膜性腎症の抗PLA2R抗体と予後規定因子が寛解導入に与える影響 (2013)
  • Author(s): 武藤 玲子、伊藤 衣里、秋山 真一、尾崎 武徳、加藤 佐和子、佐藤 和一、丸山 彰一、松尾 清一
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 20130510-20130512
• [Presentation] 進行性腎障害調査研究班の研究成果と課題 (2013)
  • Author(s): 丸山 彰一、松尾 清一
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 20130510-20130512
• [Presentation] ラットanti-GBM腎炎に対する脂肪由来間葉系幹細胞治療で誘導されるマクロファージフェノタイプの詳細検討 (2013)
  • Author(s): 古橋 和拡、坪井 直毅、清水 明日花、金 恒秀、勝野 敬之、安田 香、尾崎 武徳、佐藤 和一、松尾 清一、丸山 彰一
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 20130510-20130512
• [Presentation] 腎動態シンチグラフィによるパラアミノ馬尿酸クリアランス値の検証 (2013)
  • Author(s): 今井 順子、安田 宜成、杉浦 由姫乃、松本 祐之、加藤 佐和子、濱田 昌実、丹羽 操、後藤 資実、林 睦晴、柴田 佳菜子、松尾 清一
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 20130510-20130512
• [Presentation] CD147はCD4+ T細胞を制御し、実験ループス腎炎の病勢を抑制する (2013)
  • Author(s): 前田 佳哉輔、小杉 智規、増田 智広、長屋 啓、前田 麻友子、佐藤 由香、小島 博、佐藤 和一、丸山 彰一、松尾 清一
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 20130510-20130512
• [Presentation] 造影CTオーダ時の腎機能把握とeGFR分布について (2013)
  • Author(s): 柴田 佳菜子、安田 宜成、岩野 信吾、外山 和男、阿知波 正剛、加藤 佐和子、丸山 彰一、中尾 誠、長縄 慎二、松尾 清一
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Year and Date: 20130510-20130512