• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2013 Fiscal Year Final Research Report

Influence of ambient neuromodulators on learning through hetero-GPCR interplay

Research Project

  • PDF
Project/Area Number 23500384
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neuroscience in general
Research InstitutionUniversity of Toyama

Principal Investigator

TABATA Toshihide  富山大学, 大学院理工学研究部(工学), 准教授 (80303270)

Co-Investigator(Renkei-kenkyūsha) KAMIKUBO Yuji  順天堂大学, 医学部, 助教 (80509670)
Project Period (FY) 2011 – 2013
KeywordsGタンパク質 / シナプス可塑性 / ニューロン / 受容体 / 学習 / 小脳 / 生理学 / 神経科学
Research Abstract

In cerebellar Purkinje cells, B-type gamma-aminobutyric acid receptor (GABAbR) and type-1 adenosine receptor (A1R) are suggested to modulate type-1 metabotropic glutamate receptor (mGluR1) whose intracellular signaling triggers induction of cerebellar long-term depression (LTD). Using a machine vision-based optokinetic reflex (OKR) measuring system, we found that in mice, cerebellar injection of a GABAbR agonist facilitated OKR adaptation, a cerebellar LTD-dependent learning. Moreover, using in-vitro preparations, we found that A1R interacted with mGluR1 via its C-terminus and that A1R activation suppressed the LTD of Purkinje cell's glutamate-responsiveness by lowering mGluR1's ligand-sensitivity in a G protein-independent manner. The hetero-G protein-coupled receptor interplay may influence central synaptic plasticity and learning.

  • Research Products

    (16 results)

All 2014 2013 2011 Other

All Journal Article (8 results) (of which Peer Reviewed: 4 results) Presentation (6 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] The synaptic targeting of mGluR1 by its carboxyl-terminal domain is crucial for cerebellar function2014

    • Author(s)
      Y. Ohtani, M. Miyata, K. Hashimoto, T. Tabata, Y. Kishimoto, M. Fukaya, D. Kase, H. Kassai, K. Nakao, T. Hirata, M. Watanabe, M. Kano, A. Aiba
    • Journal Title

      Journal of Neuroscience

      Volume: 34(7) Pages: 2702-2712

    • DOI

      10.1523/JNEUROSCI.3542-13.2014

    • Peer Reviewed
  • [Journal Article] Activation of cerebellar B-type gamma-aminobutyric acid receptor mdulates optokinetic reflex adaptation2014

    • Author(s)
      Y. Shirai, T. Sasajima, S. Uchiyama, M. Takegoshi, E. Tsushima, T. Tabata
    • Journal Title

      Yakugaku Zasshi

      Volume: 134(3) Pages: 439-445

    • DOI

      10.1248/yakushi.13-00233

    • Peer Reviewed
  • [Journal Article] Functional cooperation of metabotropic adenosine and glutamate receptors regulates possynaptic plasticity in the cerebellum2013

    • Author(s)
      Y. Kamikubo, T. Shimomura, Y. Fujita, T. Tabata, T. Kashiyama, T. Sakurai, K. Fukurotani, M. Kano
    • Journal Title

      Journal of Neuroscience

      Volume: 33(47) Pages: 18661-18671

    • DOI

      10.1523/JNEUROSCI.5567-12.2013

    • Peer Reviewed
  • [Journal Article] A simple machine vision-driven system for measuring optokinetic reflex in small animals2013

    • Author(s)
      Y. Shirai, K. Asano, Y. Takegoshi, S. Uchiyama, Y. Nonobe, T. Tabata
    • Journal Title

      Journal of Physiological Sciences

      Volume: 63(5) Pages: 395-399

    • DOI

      10.1007/s12576-013-0276-5

    • Peer Reviewed
  • [Journal Article] Optokinetic reflex measurement system for mice - a biomedical application of machine vision and PIC microcontroller2013

    • Author(s)
      A. Fujita, T. Fukushima, T. Tabata
    • Journal Title

      Proceedings of Biometrics Workshop

      Volume: BioX2013-P5 Pages: 9-11

  • [Journal Article] GPCR へテロ複合体形成による神経伝達の制御2013

    • Author(s)
      上窪裕二, 田端俊英
    • Journal Title

      Clinical Neuroscience

      Volume: 32(1)2 Pages: 8-9

  • [Journal Article] GPCR 複合体形成2013

    • Author(s)
      上窪裕二, 田端俊英
    • Journal Title

      Clinical Neuroscience

      Volume: 31(12) Pages: 1354-1355

  • [Journal Article] 中枢神経におけるGPCR とイオンチャネルの連関2013

    • Author(s)
      田端俊英, 野々部裕樹
    • Journal Title

      Clinical Neuroscience

      Volume: 31(6) Pages: 638-639

  • [Presentation] マウス視機性動眼反射測定システム-マシンビジョンとPIC マイコンの医・生物学的応用2013

    • Author(s)
      藤田陽, 福嶋才貴, 田端俊英
    • Organizer
      電子情報通信学会バイオメトリクス研究会
    • Place of Presentation
      富山県立大学(射水市)
    • Year and Date
      2013-05-24
  • [Presentation] 視機性動眼反射を用いた小動物における認知・学習機能の定量化システム2011

    • Author(s)
      田端俊英, 浅野健太
    • Organizer
      Bio Japan 2011
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      20111005-07
  • [Presentation] マシン・ビジョンを用いた小動物の視機性動眼反射測定システム2011

    • Author(s)
      田端俊英
    • Organizer
      国際バイオEXPO 2011
    • Place of Presentation
      東京ビッグサイト(東京)
    • Year and Date
      20110629-0701
  • [Presentation] 小動物用視機性動眼反射測定装置の実用化・製品化2011

    • Author(s)
      田端俊英, 浅野健太
    • Organizer
      富山大学コラボフェスタ
    • Place of Presentation
      富山大学(富山市)
    • Year and Date
      2011-09-28
  • [Presentation] マウスにおけるGABAb 受容体活性化による視機性動眼反射順応の促進 : マシン・ビジョンを応用した測定システムによる解析2011

    • Author(s)
      田端俊英, 白井義啓, 内山周, 篠島俊史, 竹腰昌広, 立川公博, 袋谷賢吉
    • Organizer
      日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-09-15
  • [Presentation] アデノシンA1 受容体と代謝型グルタミン酸受容体の相互作用による小脳LTDの調整2011

    • Author(s)
      上窪裕二, 藤田洋介, 下村岳司, 宮島隆彰, 藤野真弘, 田端俊英, 袋谷賢吉, 狩野方伸
    • Organizer
      日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-09-15
  • [Remarks]

    • URL

      http://niteut.eng.u-toyama.ac.jp/Lab_NIT/Intro_ai_za.html

  • [Patent(Industrial Property Rights)] 保定装置

    • Inventor(s)
      白井義啓, 田端俊英
    • Industrial Property Rights Holder
      国立大学法人富山大学
    • Industrial Property Rights Type
      A61D 3/100特開2011-130906
    • Patent Publication Number
      特開2011-130906

URL: 

Published: 2015-07-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi