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2013 Fiscal Year Final Research Report

Altered dopaminergic system by environmental enrichment in ADHD model rat

Research Project

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Project/Area Number 23500395
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neuroscience in general
Research InstitutionNagoya City University

Principal Investigator

HIDA HIDEKI  名古屋市立大学, 医学(系)研究科(研究院), 教授 (00305525)

Co-Investigator(Renkei-kenkyūsha) MISUMI Sachiyo  名古屋市立大学, 大学院・医学研究科, 助教 (70529148)
MASUDA Tadashi  名古屋市立大学, 大学院・医学研究科, 助教 (10423641)
ISHIDA Akimasa  名古屋市立大学, 大学院・医学研究科, 助教 (20632607)
Project Period (FY) 2011 – 2013
Keywordsenrichment / emotion / growth / CART / dopamine / amygdala / ADHD / rat
Research Abstract

To investigate the relation between environmental enrichment (EE) during the period of development and formation of emotion, spontaneously hypertensive rat (SHR) were allowed to EE for 5 weeks from P25, followed by assessment of emotional behavior and analysis in dopaminergic system focusing on cocaine and amphetamine regulated transcript (CART).
In open-field test, total distance (parameter for hyperactivity) and locomotion speed (impulsivity) were deceased in EE-grown rats. In cylinder test, more quick adaptation to novelty was shown in EE. CART is enhanced by EE in the amygdala (Amy) by real-time PCR, and many CART-positive cells was observed in the Amy, especially in the central nucleus of amygdale (CeA). CART colocalized in GABAergic cells that were not immnoreactive to parvalbumin and calretinin. Data suggested that EE induced CART expression in CeA that colocalized in GABAergic neurons probably relating to decreased hyperactivity and anxiety-like behavior in SHR.

  • Research Products

    (16 results)

All 2014 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (10 results) Remarks (1 results)

  • [Journal Article] Differentiation of oligodendrocytes from mouse induced pluripotent stem cells without serum2013

    • Author(s)
      Misumi S, Nishigaki R, Ueda Y, Watanabe Y, Shimizu Y, Ishida A, Jung CG, Hida H
    • Journal Title

      Transl Stroke Res

      Volume: 4(2) Pages: 149-157

    • DOI

      10.1007/s12975-012-0250-1

    • Peer Reviewed
  • [Journal Article] Increased astrocytic ATP release resulted in enhanced ezitability of the hippocampus2013

    • Author(s)
      Lee HJ, Yamazaki Y, Tanaka KF, Furuya K, Sokabe M, Hida H, Takao K, Miyakawa T, Fujii S, Ikenaka K
    • Journal Title

      Glia

      Volume: 61(2) Pages: 210-24

    • DOI

      10.1002/glia.22427

    • Peer Reviewed
  • [Journal Article] Capillary blood flow around microglial somata determines dynamics of microglial processes in ischemic conditions2011

    • Author(s)
      Masuda T, Croom D, Hida H, Kirov SA
    • Journal Title

      Glia

      Volume: 59(11) Pages: 1744-53

    • DOI

      10.1002/glia.21220

    • Peer Reviewed
  • [Journal Article] Early onset of forced impaired forelimb use causes recovery of forelimb skilled motor function but no effect on gross sensory-motor function after capsular hemorrhage in rats2011

    • Author(s)
      Ishida A, Tamakoshi K, Hamakawa M, Shimada H, Nakashima H, Masuda T, Hida H, Ishida K
    • Journal Title

      Behav Brain Res

      Volume: 225(1) Pages: 126-134

    • DOI

      10.1016/j.bbr.2011.06.036

    • Peer Reviewed
  • [Journal Article] Minor neuronal damage and recovered cellular proliferation in the hippocampus after continuous unilateral forelimb restraint in normal rats2011

    • Author(s)
      Ishida A, Ueda Y, Ishida K, Misumi S, Masuda T, Fujita M, Hida H
    • Journal Title

      J Neurosci Res

      Volume: 89(6) Pages: 457-65

    • DOI

      10.1002/jnr.22566

    • Peer Reviewed
  • [Presentation] Higher expression of cocaine and amphetamine regulated transcript (CART) peptide in the amygdala rather than the medial prefrontal cortex in ADHD model rat2014

    • Author(s)
      Shimizu Y, Yokoyama Y, Misumi S, Ishida A, Jung CG, Hida H
    • Organizer
      第91回日本生理学会
    • Place of Presentation
      鹿児島大学 群元キャンパス 鹿児島県
    • Year and Date
      20140316-18
  • [Presentation] Social behavior by umami intake during the period of development is enhanced by vagus nerve afferent in ADHD model rat2014

    • Author(s)
      Yokoyama Y, Shimizu Y, Ueda Y, Misumi M, Ishida A, Jung C-G, Yokoi M, Hida H
    • Organizer
      第91回日本生理学会
    • Place of Presentation
      鹿児島大学 群元キャンパス 鹿児島県
    • Year and Date
      20140316-18
  • [Presentation] 発達期の経口うま味刺激における迷走神経を介した社会性亢進2013

    • Author(s)
      横山善弘, 清水由布子, 上田佳朋, 三角吉代, 石田章真, 鄭 且均, 横井基夫, 飛田秀樹
    • Organizer
      第60回中部日本生理学会
    • Place of Presentation
      岐阜大学医学部記念会館ホール 岐阜県
    • Year and Date
      20131025-26
  • [Presentation] Behavioral effect of environmental enrichment on attention deficit hyperactivity disorder model rat : CART expression in the medial prefrontal cortex and the amygdala2013

    • Author(s)
      Shimizu Y, Yokoyama Y, Misumi S, Ishida A, Jung CG, Hida H
    • Organizer
      日本神経科学会
    • Place of Presentation
      国立京都国際会館 京都府
    • Year and Date
      20130620-23
  • [Presentation] Hyperactivity is reduced by environmental enrichment during growing period in an ADHD model rat accompanied with enhanced CART expression in medial prefrontal cortex2012

    • Author(s)
      Shimizu Y, Nishigaki R, Watanabe Y, Ueda Y, Misumi S, Masuda T, Hida H
    • Organizer
      北米神経科学会
    • Place of Presentation
      アメリカ ニューオリンズ コンベンションセンター
    • Year and Date
      20121013-17
  • [Presentation] Oral intake of monosodium glutamate during growing period alters social behavior in a rat model of attention-deficit /hyperactivity disorder2012

    • Author(s)
      Yokoyama Y, Shimizu Y, Misumi S, Ishida A, Yokoi M, Hida H
    • Organizer
      北米神経科学会
    • Place of Presentation
      アメリカ ニューオリンズ コンベンションセンター
    • Year and Date
      20121013-17
  • [Presentation] Decreased anxiety-induced behavior by environmental enrichment both in SHR and Wistar rats2012

    • Author(s)
      Shimizu Y, Nishigaki R, Yokoyama Y, Waatanabe Y, Mizumi S, Hida H
    • Organizer
      日本神経科学会
    • Place of Presentation
      名古屋国際会議場, 名古屋市
    • Year and Date
      20120918-21
  • [Presentation] Reduced hyperactivity with CART expression in the prefrontal cortex in ADHD model rats2012

    • Author(s)
      Shimizu Y, Watanabe Y, Yokoyama Y, Cho R, Misumi S, Masuda T, Hida H
    • Organizer
      第89回日本生理学会
    • Place of Presentation
      松本文化会館 長野県
    • Year and Date
      2012-03-31
  • [Presentation] Environmental enrichment in ADHD model rat : decreased hyperactivity and impulsivity in young spontaneously hypertensive rats2011

    • Author(s)
      Shimizu Y, Cho Y, Nishigaki R, Watanabe Y, Masuda T, Misumi M, Hida H
    • Organizer
      北米神経科学会
    • Place of Presentation
      アメリカ ワシントンDC コンベンションセンター
    • Year and Date
      2011-11-15
  • [Presentation] Decrease in hyperactivity and impulsivity by environmental enrichment in attention deficit hyperactivity disorder model rat2011

    • Author(s)
      Shimizu Y, Ueda Y, Cho R, Nishigaki R, Hida H
    • Organizer
      第34回日本神経科学会
    • Place of Presentation
      横浜パシフィコ 横浜市
    • Year and Date
      2011-09-15
  • [Remarks]

    • URL

      http://www.med.nagoya-cu.ac.jp/brain-physiol.dir/

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Published: 2015-07-16  

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