• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2013 Fiscal Year Final Research Report

Mechanisms for changes of endocannabinoid system in the brain

Research Project

  • PDF
Project/Area Number 23500466
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurophysiology and muscle physiology
Research InstitutionKanazawa University

Principal Investigator

OHNO-SHOSAKU Takako  金沢大学, 保健学系, 教授 (60179025)

Project Period (FY) 2011 – 2013
Keywords脳・神経 / ニューロン / 神経科学 / カンナビノイド / ストレス / 大脳基底核
Research Abstract

Using various methods ranging from electrophysiology and molecular biology to behavioral testing with rodents and humans, we examined the interaction between stress and endocannabinoid system and their contributions to brain function. Our findings are as follows: (1) glucocorticoid-treatment increases neuronal excitability, and also decreases expression of CB1 cannabinoid receptors; (2) the endocannabinoid 2-AG has a CB1-independent excitatory action on neurons; (3) basal ganglia-dependent motor learning is impaired in CB1-knockout mice, and (4) learning strategy in probabilistic selection task depending on basal ganglia is altered in patients with mood disorders. These results are not inconsistent with the hypothesis that endocannabinoid system is involved in stress-induced alterations in brain function.

  • Research Products

    (11 results)

All 2014 2013 2012 2011

All Journal Article (4 results) Presentation (6 results) Book (1 results)

  • [Journal Article] Endocannabinoid-mediated retrograde modulation of synaptic transmission2014

    • Author(s)
      Ohno-Shosaku T, Kano M
    • Journal Title

      Curr Opin Neurobiol

      Volume: (in press)

    • DOI

      10.1016/j.conb.2014.03.017

  • [Journal Article] Acute inhibition of diacylglycerol lipase blocks endocannabinoid-mediated retrograde signalling : evidence for on-demand biosynthesis of 2-arachidonoylglycerol2013

    • Author(s)
      Hashimotodani Y, Ohno-Shosaku T, Tanimura A, Kita Y, Sano Y, Shimizu T, Di Marzo V, Kano M
    • Journal Title

      J Physiol

      Volume: 591 Pages: 4765-76

  • [Journal Article] Intracellular calcium level is an important factor influencing ion channel modulations by PLC-coupled metabotropic receptors in hippocampal neurons2013

    • Author(s)
      Sugawara Y, Echigo R, Kashima K, Minami H, Watanabe M, Nishikawa Y, Muranishi M, Yoneda M, Ohno-Shosaku T
    • Journal Title

      Brain Res

      Volume: 1512 Pages: 9-21

  • [Journal Article] Cannabinoids inhibit peptidoglycan-induced phosphorylation of NF-κB and cell growth in U87MG human malignant glioma cells2012

    • Author(s)
      Echigo R, Sugimoto N, Yachie A, Ohno-Shosaku T
    • Journal Title

      Oncol Rep

      Volume: 28 Pages: 1176-80

  • [Presentation] 2-アラキドノイルグリセロールと関連物質によるシナプス伝達調節2014

    • Author(s)
      少作隆子
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      20140911-13
  • [Presentation] 運動学習における CB1 受容体の役割 : 3レバー・オペラント課題を用いて2014

    • Author(s)
      米田貢
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      20140911-13
  • [Presentation] 低酸素環境下でのがん細胞の動向2014

    • Author(s)
      杉本直俊
    • Organizer
      第91回日本生理学会大会サテライト企画, 第9回環境生理学プレコングス
    • Place of Presentation
      国民宿舎 レインボー桜島(鹿児島県)
    • Year and Date
      2014-03-15
  • [Presentation] 内因性カンナビノイド 2-AGのカンナビノイド受容体を介さない神経活動促進作用2013

    • Author(s)
      少作隆子
    • Organizer
      Neuro2013
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      20130620-23
  • [Presentation] 内因性カンナビノイド 2-AGのカンナビノイド受容体を介さない作用2013

    • Author(s)
      少作隆子
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      20130327-29
  • [Presentation] ヒト神経膠腫 U87 細胞における CB1 受容体を介したカンナビノイドのTLR2 誘発性炎症反応の抑制作用2011

    • Author(s)
      越後亮介
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-09-15
  • [Book] 2-アラキドノイルグリセロールの逆行性シグナルとしての役割, 医学のあゆみ2014

    • Author(s)
      少作隆子
    • Total Pages
      1009-1013
    • Publisher
      医歯薬出版

URL: 

Published: 2015-07-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi