2013 Fiscal Year Final Research Report
Toward therapeutic systems for Alzheimer's Disease by removal of blood Abeta: Investigation of Abeta in the brain of dialysis patients
| Project/Area Number |
23500531
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAGUCHI Kazunori 藤田保健衛生大学, 医療科学部, 講師 (00508468)
NAKAI Shigeru 藤田保健衛生大学, 医療科学部, 教授 (20345896)
ITO Shinji 藤田保健衛生大学, 医学部, 准教授 (40572079)
KATO Masao 藤田保健衛生大学, 医学研究科, 研究員 (50599537)
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| Research Collaborator |
SAKAI Kazuyoshi 藤田保健衛生大学, 医療科学部, 准教授 (90215583)
ITO Kengo 国立長寿医療研究センター, 認知症先進医療開発センター脳機能画像診断開発部 (70184653)
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| Project Period (FY) |
2011 – 2013
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| Keywords | アルツハイマー病 / アミロイドβ / 治療機器 / 血液透析 / 脳病理 / 認知機能 / アフェレシス |
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| Research Abstract |
To create therapeutic systems for Alzheimer's Disease by removal of blood Abeta, the followings were investigated regarding hemodialysis which effectively removes blood Abeta; 1) Abeta depositions as senile plaques in the postmortem brains of hemodialysis patients were significantly less than those of patients without dialysis. 2) The concentrations of plasma Abeta increased along with the decline of renal functions. Moreover, the renal failure patients without hemodialysis and with poorer renal functions showed lower cognitive functions. 3) Along with the initiation of hemodialysis of 5 renal failure patients (64.0+-12.6 y.o.), the concentration of blood Abeta1-40, Abeta1-42, Abeta-oligomers were decreased and the cognitive functions were improved to or kept in full scores.
These results indicates that the blood Abeta reduction systems is worth investigating further as therapeutic systems for Alzheimer's Disease.
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[Journal Article] A Potential therapeutic system for Alzheimer's Disease Using Adsorbents with alkyl ligands for removal of blood Amyloid β2013
Author(s)
Kazunori Kawaguchi, Masato Takeuchi, Hiromasa Yamagawa, Kazutaka Murakami, Shigeru Nakai, Hideo Hori, Atsushi Ohashi, Yoshiyuki Hiki, Nobuo Suzuki, Satoshi Sugiyama, Yukio Yuzawa, Nobuya Kitaguchi
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Journal Title
J Artificial Organs16
Volume: 16
Pages: 211-217
Peer Reviewed
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[Journal Article] Potential therapeutic system for Alzheimer's Disease: Removal of blood Aβs by hemodialzyers and its effect on the cognitive functions of renal failure patients2012
Author(s)
Masao Kato, Kazunori Kawaguchi, Sigeru Nakai, Kazutaka Murakami, Hideo Hori, Atsushi Ohashi, Yoshiyuki Hiki, Shinji Ito, Yasunobu Shimano, Nobuo Suzuki, Satoshi Sugiyama, Hiroshi Ogawa, Hiroko Kushimoto, Tatsuro Mutoh, Yukio Yuzawa, Nobuya Kitaguchi
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Journal Title
J Neural Transmission
Volume: 119(12)
Pages: 1533-1544
Peer Reviewed
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[Journal Article] 血漿アミロイドβの増加は腎機能障害及び認知の低下に関連する2011
Author(s)
加藤政雄, 藤田孝, 村上和隆, 湯澤由紀夫杉山敏, 伊藤信二, 武藤多津郎, 堀秀生, 川口和紀, 大橋篤, 中井滋, 比企能之, 北口暢哉
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Journal Title
藤田学園医学会誌
Volume: 35
Pages: 111-117
Peer Reviewed
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[Journal Article] Reduction of Alzheimer's Disease Amyloid β in plasma by hemodialysis and its relation to cognitive functions2011
Author(s)
Kitaguchi N., Kawaguchi K., Nakai S., Murakami K., Ito S., Hoshino H., Hori H., Ohashi A., Shimano Y., Suzuki N., Yuzawa Y., Mutoh T., Sugiyama S
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Journal Title
Blood Purification
Volume: 32
Pages: 57-62
Peer Reviewed
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[Presentation] Toward the novel method of treatment for Alzheimer's disease; The optimal conditions of Aβ removal by dialyzers2013
Author(s)
Kazunori Kawaguchi, Hisae Toda, Sachi Oguri, Shun Ikedo, Yutarou Matsushita, Miwa Sakata, Hideo Hori, Atsushi Ohashi, Shigeru Nakai, Yoshiyuki Hiki, Nobuya Kitaguchi
Organizer
5th Congress of the International Federation for Artificial Organs
Place of Presentation
Yokohama
Year and Date
2013-09-27
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[Presentation] 血液Aβ除去によるアルツハイマー病治療 : 血液透析患者の脳画像解析2012
Author(s)
北口暢哉, 伊藤信二, 川口和紀, 村上和隆, 中井滋, 島野泰暢, 鈴木信夫, 杉山敏, 小川洋史, 久志本浩子, 堀秀生, 大橋篤, 比企能之, 湯澤由紀夫, 武藤多津郎
Organizer
認知症予防学会
Place of Presentation
北九州市
Year and Date
2012-09-07
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[Presentation] Extracorporeal Aβ Removal System (EARS) for Alzheimer's Disease therapy : Novel Devices with fragments of hollow fibers removed Aβ effectively both in vitro and in vivo2012
Author(s)
Nobuya Kitaguchi, Takehiro Gotoh, Kazunori Kawaguchi, Hideo Hori, Atsushi Ohashi, Shigeru Nakai, Shizuko Nagao, Shinji Ito, Tatsuro Mutoh, Yukio Yuzawa, Yoshiyuki Hiki
Organizer
Alzheimer ' s Association International Conference AAIC2012
Place of Presentation
Vancouver
Year and Date
2012-07-15
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[Presentation] 血中Aβ除去によるアルツハイマー病治療システムの検討 : 血液透析による血中Aβ変化と喫煙との関係2011
Author(s)
北口暢哉, 伊藤信二, 川口和紀, 村上和隆, 中井滋, 加藤政雄, 島野泰暢, 鈴木信夫, 堀秀生, 大橋篤, 比企能之, 杉山敏, 湯澤由紀夫, 武藤多津郎
Organizer
認知症学会
Place of Presentation
東京
Year and Date
2011-11-12
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[Presentation] 18ヶ月間の維持血液透析による血中Amyloid Beta-Protein(Aβ), MMSE スコアの経時変化.2011
Author(s)
川口和紀, 堀秀生, 大橋篤, 中井滋, 比企能之, 村上和隆, 湯澤由紀夫, 伊藤信二, 石田治, 島野泰暢, 武藤多津郎, 北口暢哉
Organizer
認知症学会
Place of Presentation
東京
Year and Date
2011-11-12
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[Presentation] Toward therapeutic system for Alzheimer's Disease by removal of blood Aβ: Hemodialysis improved the impaired cognitive states of renal failure patients2011
Author(s)
Nobuya Kitaguchi, Kazunori Kawaguchi, Masao Kato, Shigeru Nakai, Kazutaka Murakami, Shinji Ito, Hideo Hori, Atsushi Ohashi, Yasunobu Shimano, Nobuo Suzuki, Satoshi Sugiyama, Yoshiyuki Hiki, Tatsuro Mutoh, Yukio Yuzawa
Organizer
Alzheimer ' s Association International Conference AAIC2011
Place of Presentation
Paris
Year and Date
2011-07-18
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[Presentation] 血液透析患者における透析前後の血中Aβ濃度変化と, 認知機能, 頭部CT 所見との関連2011
Author(s)
伊藤信二, 石川等真, 引地智加, 河村直樹島さゆり, 宮下忠行, 植田晃広, 木澤真努香, 朝倉邦彦, 武藤多津郎, 川口和紀, 中井滋, 北口暢哉, 村上和隆, 湯澤由紀夫
Organizer
日本神経学会
Place of Presentation
名古屋
Year and Date
2011-05-20
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[Presentation] 血中アミロイドβ蛋白(Aβ)除去によるアルツハイマー病治療システムの構築に向けて~Aβ吸着材の吸着特性2011
Author(s)
川口和紀, 堀秀生, 村上和隆, 中井滋, 大橋篤, 島野泰暢, 鈴木信夫, 山側裕正, 湯澤由紀夫, 杉山敏, 竹内雅人, 北口暢哉
Organizer
日本医工学治療学会
Place of Presentation
岡山
Year and Date
2011-04-23
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