2013 Fiscal Year Final Research Report
R&D of a portable ultrafiltration system with a small centrifugal pump
| Project/Area Number |
23500537
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kobe University |
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Principal Investigator |
YAMANE Takashi 神戸大学, 工学(系)研究科(研究院), 教授 (10358278)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUDA Kenichi 山梨大学, 医学部救急集中治療医学講座, 教授 (60282480)
YAMAMOTO Kenichirou 東京女子医科大学, 医学部, 助教 (00434316)
NISHIDA Masahiro 産業技術総合研究所, ヒューマンライフテクノロジー部門, 主任研究員 (80357714)
KOSAKA Ryo 産業技術総合研究所, ヒューマンライフテクノロジー部門, 研究員 (10415680)
MARUYAMA Osamu 産業技術総合研究所, ヒューマンライフテクノロジー部門, 研究グループ長 (30358064)
YAMAMOTO Takahiro 神戸大学, 大学院・工学研究科, 大学院生
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| Project Period (FY) |
2011 – 2013
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| Keywords | 人工臓器工学 / 血液濾過装置 / 遠心ポンプ / 溶血 |
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| Research Abstract |
A portable hemofiltration system has been developed for emergency use as well as home care or disaster care in future. Ultrafiltration is adopted not to use 120 L dialysis water and a centrifugal pump was adopted for simple usability. Regarding the newly developed centrifugal pumps, the first model showed 30% hemolysis and the second model showed 5% hemolysis compared with that of a conventional extracorporeal pump. High hemolysis was found to be caused by the wear of a female pivot. In vitro anti-thrombogenicity tests revealed almost no thrombus except around a pivot bearing. Regarding a hemofiltration experiment, though blood circulation flow and ultrafiltration flow was able to be kept constant this time, a similar performance should be kept even for a case of fouling or hollow fiber clogging.
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