2013 Fiscal Year Final Research Report
Development of drug and gene delivery into brain with ultrasound technologies
| Project/Area Number |
23500567
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Teikyo University |
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Principal Investigator |
SUZUKI Ryo 帝京大学, 薬学部, 准教授 (90384784)
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| Co-Investigator(Renkei-kenkyūsha) |
MARUYAMA Kazuo 帝京大学, 薬学部, 教授 (30130040)
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| Project Period (FY) |
2011 – 2013
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| Keywords | リポソーム |
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| Research Abstract |
Recently, some drug and gene therapies for brain disorder have been developed. However, many drugs and genes dropped off from clinical candidates in animal and clinical phase studies because of low efficiency of brain delivery. Therefore, it is necessary to develop effective and non-invasive drug and gene delivery system. To improve this, I developed a novel gene delivery system into brain by the combination of nanobubbles and ultrasound. Our delivery system is the combination of systemic injection of nanobubbles and plasmid DNA and trans-scalp ultrasound exposure to brain. It could express reporter gene in the brain. Therefore, this ultrasound delivery system would be a minimally invasive and brain-selective gene delivery system.
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[Journal Article] Prophylactic immunization with Bubble liposomes and ultrasound-treated dendritic cells provided a four-fold decrease in the frequency of melanoma lung metastasis2012
Author(s)
Oda Y, Suzuki R, Otake S, Nishiie N, Hirata K, Koshima R, Nomura T, Utoguchi N, Kudo N, Tachibana K, Maruyama K
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Journal Title
J Control Release
Volume: 160
Pages: 362-366
DOI
Peer Reviewed
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