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2013 Fiscal Year Final Research Report

Development of drug and gene delivery into brain with ultrasound technologies

Research Project

  • PDF
Project/Area Number 23500567
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical systems
Research InstitutionTeikyo University

Principal Investigator

SUZUKI Ryo  帝京大学, 薬学部, 准教授 (90384784)

Co-Investigator(Renkei-kenkyūsha) MARUYAMA Kazuo  帝京大学, 薬学部, 教授 (30130040)
Project Period (FY) 2011 – 2013
Keywordsリポソーム
Research Abstract

Recently, some drug and gene therapies for brain disorder have been developed. However, many drugs and genes dropped off from clinical candidates in animal and clinical phase studies because of low efficiency of brain delivery. Therefore, it is necessary to develop effective and non-invasive drug and gene delivery system. To improve this, I developed a novel gene delivery system into brain by the combination of nanobubbles and ultrasound. Our delivery system is the combination of systemic injection of nanobubbles and plasmid DNA and trans-scalp ultrasound exposure to brain. It could express reporter gene in the brain. Therefore, this ultrasound delivery system would be a minimally invasive and brain-selective gene delivery system.

  • Research Products

    (7 results)

All 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (3 results) (of which Invited: 1 results) Remarks (1 results)

  • [Journal Article] Efficient suppression of murine intracellular adhesion molecule-1 using ultrasound -responsive and mannose-modified lipoplexes inhibits acute hepatic inflammation2012

    • Author(s)
      Un K, Kawakami S, Yoshida M, Higuchi Y, Suzuki R, Maruyama K, Yamashita F, Hashida M
    • Journal Title

      Hepatology

      Volume: 56 Pages: 259-269

    • DOI

      10.1002/hep.25607

    • Peer Reviewed
  • [Journal Article] Prophylactic immunization with Bubble liposomes and ultrasound-treated dendritic cells provided a four-fold decrease in the frequency of melanoma lung metastasis2012

    • Author(s)
      Oda Y, Suzuki R, Otake S, Nishiie N, Hirata K, Koshima R, Nomura T, Utoguchi N, Kudo N, Tachibana K, Maruyama K
    • Journal Title

      J Control Release

      Volume: 160 Pages: 362-366

    • DOI

      10.1016/j.jconrel.2011.12.003

    • Peer Reviewed
  • [Journal Article] Involvement of activated transcriptional process in efficient gene transfection using unmodified and mannose-modified bubble lipoplexes with ultrasound exposure2011

    • Author(s)
      Un K, Kawakami S, Higuchi Y, Suzuki R, Maruyama K, Yamashita F, Hashida M
    • Journal Title

      J Control Release

      Volume: 156 Pages: 355-363

    • DOI

      10.1016/j.jconrel.2011.06.040

    • Peer Reviewed
  • [Presentation] Cancer gene therapy with nano-bubble associated sonoporation2013

    • Author(s)
      Ryo Suzuki
    • Organizer
      ICMBU2013
    • Place of Presentation
      台湾大学
    • Year and Date
      20131022-23
  • [Presentation] 脳に対する超音波遺伝子デリバリーに関する基礎的検討2013

    • Author(s)
      鈴木亮
    • Organizer
      日本超音波医学会・基礎技術研究会
    • Place of Presentation
      北海道大学
    • Year and Date
      2013-08-03
  • [Presentation] リポソーム技術を駆使した超音波DDS の開発2012

    • Author(s)
      鈴木亮
    • Organizer
      日本DDS学会
    • Place of Presentation
      札幌
    • Year and Date
      20120704-05
    • Invited
  • [Remarks] ホームページ

    • URL

      http://www.teikyo-dds-lab.com/

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Published: 2015-07-16  

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