2013 Fiscal Year Final Research Report
Changes in microRNAs during hypoxia-induced physiological adaptation
| Project/Area Number |
23500770
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Hokkaido University of Education |
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Principal Investigator |
SUZUKI Junichi 北海道教育大学, 教育学部, 教授 (80261379)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 運動生理学 / スポーツ生理学 / 酸素センシング機構 / 血管新生 / マイクロRNA |
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| Research Abstract |
During exercise, oxygen tension in the active muscle falls to 1/10 of resting value. This hypoxic stimulus facilitates an accumulation of hypoxia-inducible factor (HIF-1alpha), and causes various adaptive changes in skeletal muscle. This study was designed to examine how microRNAs react to acute and/or chronic exercise. The present results suggest that exercise training suppresses expression of anti-angiogenic microRNAs, thus facilitate capillary growth, in young rats. However, in aged-rats, exercise training upregulates both anti- and pro-angiogenic microRNAs, thereby exercise-induced capillary growth may be slightly suppressed.
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