2013 Fiscal Year Final Research Report
Pathophysiology of non-obese subjects with impaired glucose tolerance
| Project/Area Number |
23500857
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Juntendo University |
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Principal Investigator |
SATO Fumihiko 順天堂大学, 医学部, 准教授 (10445538)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 耐糖能障害 / インスリン抵抗性 / インスリン分泌 |
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| Research Abstract |
The mechanisms of hyperglycemia in non-obese IGT subjects are not fully understood. In this project, to clarify the pathophysiology in non-obese IGT, we performed glucose clamp and oral glucose tolerance test with double glucose tracer. Our preliminary result suggested that impaired hepatic glucose uptake and insulin resistance in muscle may contribute to hyperglycemia in IGT subjects. Further experiment will be required for confirming these results.
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