2013 Fiscal Year Final Research Report
The onset-preventing and suppressive effects of antioxidants on non-alcoholic steatohepatitis in mice
| Project/Area Number |
23500969
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Fukuoka Women's University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山元 涼子 公立大学法人熊本県立大学, 環境共生学部食健康科学科, 助手 (50580429)
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| Co-Investigator(Renkei-kenkyūsha) |
田中 芳明 久留米大学, 医学部安全管理部, 教授 (50188348)
山田 健一 九州大学, 薬学部薬学研究科生物物理薬学, 准教授 (60346806)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 特殊栄養食品 / 非アルコール性脂肪肝炎 / 抗酸化物質 / ビタミンＥ / 希少糖アロース / イソロイシン / ロイシン |
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| Research Abstract |
Non-alcoholic steatohepatitis (NASH) is considered to be one of the important lifestyle-related diseases that are not currently manageable medically. No definite clinical effects have as yet been recognized.
We noted that this disease develops with oxidative stress and thus conducted an examination on NASH prevention focusing mainly on the development of disease models and administration of antioxidants. It was confirmed that the disease which stably develops over a relatively-short time period in STAM mice, a new disease model, is very similar to the human disease NASH. We also examined the effects of administering vitamin E, amino acids (isoleucine, leucine), and D-allose, an isomer of D-glucose, using these mice and found that the administration of these substances significantly prevented liver disorders in STAM mice.
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