Effect of oral immunotherapy with hypoallergenic formula for severe milk allergenic patients

2013 Fiscal Year Final Research Report

• Project/Area Number: 23500973
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Fujita Health University
• Principal Investigator: INUO Chisato 藤田保健衛生大学, 医学部, 助教 (30586780)
• Co-Investigator(Kenkyū-buntansha): URISU Atsuo 藤田保健衛生大学, 坂文種報徳會病院 小児科, 客員教授 (20193972)
• Project Period (FY): 2011 – 2013
• Keywords: 低アレルゲン

Research Abstract

To cow's milk allergy patients, the usefulness of immunotherapy to induce remission by taking milk have been reported. However, skin symptoms, gastrointestinal symptoms, and respiratory symptoms are induced frequently by the milk oral immunotherapy. In this study, we investigated the safety and efficacy of oral immunotherapy using peptide milk. The peripheral blood basophils activations in the blood of the severe milk allergy patients against peptides milk were lower than that of normal milk. In the double-blind food challenge test, the severe milk allergy patients can eat the larger amount of peptide milk than that of normal milk. The oral immunotherapy using peptides milk increased the durable amount of milk without any symptoms for the milk allergy patients in patients of 80%.

Research Products

• [Journal Article] Food sensitization in Japanese infants is associated with a common Filaggrin variant, Annals of allergy, asthma & immunology : official publication of the American College of Allergy (2013)
  • Author(s): Nomura T. , Tsuge I. , Inuo C. , Nakajima Y. , Kondo Y. , Sugiura S. , Murata H. , Iguchi T. , Terada A. , Saitoh S. , Hashimoto S., Urisu A
  • Journal Title: Asthma, & Immunology Volume: 110 Pages: 388-390
  • Peer Reviewed
• [Journal Article] Tissue transglutaminase generates deamidated epitopes on gluten, increasing reactivity with hydrolyzed wheat protein-sensitized IgE (2013)
  • Author(s): Nakamura R. , Nakamura R. , Sakai S. , Adachi R. , Hachisuka A. , Urisu A. , Fukutomi Y., Teshima R
  • Journal Title: J. Allergy Clin. Immunol Volume: 132 Pages: 1436-8
  • Peer Reviewed
• [Journal Article] Anaphylactic reaction to dietary oats (2013)
  • Author(s): Inuo C. , Kondo Y. , Itagaki Y. , Kurihara K. , Tsuge I. , Yoshikawa T., Urisu A
  • Journal Title: Ann. Allergy. Asthma. Immunol Volume: 110 Pages: 305-6
  • Peer Reviewed
• [Journal Article] Allergenic potential of rice-pollen proteins: expression, immuno-cross reactivity and IgE-binding (2013)
  • Author(s): Hirano K. , Hino S. , Oshima K. , Okajima T. , Nadano D. , Urisu A. , Takaiwa F., Matsuda T
  • Journal Title: J. Biochem Volume: 154 Pages: 195-205
  • Peer Reviewed
• [Journal Article] Specific detection of potentially allergenic peach and apple in foods using polymerase chain reaction (2012)
  • Author(s): Watanabe S. , Taguchi H. , Temmei Y. , Hirao T. , Akiyama H. , Sakai S. , Adachi R. , Urisu A., Teshima R
  • Journal Title: J. Agric. Food Chem Volume: 60 Pages: 2108-15
  • Peer Reviewed
• [Journal Article] New approach for improving the safety of oral immunotherapy for food allergy (2012)
  • Author(s): Urisu A. , Tanaka K. , Ogura K. , Naruse N. , Hirata N. , Nakajima Y. , Inuo C. , Suzuki S. , Ando H. , Kondo Y. , Tsuge I. , Yamada K., Kimura M
  • Journal Title: Clinical & Experimental Allergy Reviews Volume: 12 Pages: 25-28
  • Peer Reviewed
• [Journal Article] Evaluation of the luciferase assay-based in vitro elicitation test for serum IgE (2012)
  • Author(s): Nakamura R. , Ishiwatari A. , Higuchi M. , Uchida Y. , Nakamura R. , Kawakami H. , Urisu A., Teshima R
  • Journal Title: Allergology international : official journal of the Japanese Society of Allergology Volume: 61 Pages: 431-7
  • Peer Reviewed
• [Journal Article] Generation of transgenic rice lines with reduced contents of multiple potential allergens using a null mutant in combination with an RNA silencing method (2011)
  • Author(s): Wakasa Y. , Hirano K. , Urisu A. , Matsuda T., Takaiwa F
  • Journal Title: Plant Cell Physiol Volume: 52 Pages: 2190-9
  • Peer Reviewed
• [Journal Article] Japanese Society of A.;Japanese guideline for food allergy (2011)
  • Author(s): Urisu A., Ebisawa M., Mukoyama T., Morikawa A., Kondo N
  • Journal Title: Allergology international : official journal of the Japanese Society of Allergology Volume: 60 Pages: 221-36
  • Peer Reviewed
• [Journal Article] Effects of oral administration of Lactobacillus acidophilus L-92 on the symptoms and serum markers of atopic dermatitis in children (2011)
  • Author(s): Torii S. , Torii A. , Itoh K. , Urisu A. , Terada A. , Fujisawa T. , Yamada K. , Suzuki H. , Ishida Y. , Nakamura F. , Kanzato H. , Sawada D. , Nonaka A. , Hatanaka M., Fujiwara S
  • Journal Title: Int. Arch. Allergy Immunol Volume: 154 Pages: 236-45
  • Peer Reviewed
• [Journal Article] Differential detection of shrimp and crab for food labeling using polymerase chain reaction (2011)
  • Author(s): Taguchi H. , Watanabe S. , Temmei Y. , Hirao T. , Akiyama H. , Sakai S. , Adachi R. , Sakata K. , Urisu A., Teshima R
  • Journal Title: J. Agric. Food Chem Volume: 59 Pages: 3510-9
  • Peer Reviewed
• [Journal Article] A patient with salmon roe allergy showing taxonomy-unrelated cross-reactivity with sea urchin roe (2011)
  • Author(s): Kondo Y. , Tanaka K. , Inuo C. , Tsuge I., Urisu A
  • Journal Title: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology Volume: 107 Pages: 283-4
  • Peer Reviewed
• [Journal Article] Molecular diagnosis of egg allergy (2011)
  • Author(s): Caubet J.C. , Kondo Y. , Urisu A., Nowak-Wegrzyn A
  • Journal Title: Curr. Opin. Allergy Clin. Immunol Volume: 11 Pages: 210-5
  • Peer Reviewed
• [Presentation] ミルクアレルギー児における活性化マーカーCD154 を用いた抗原特異的 T 細胞の解析 (2014)
  • Author(s): 山脇一夫, 柘植郁哉, 大久保悠里, 中島陽一, 犬尾千聡, 野村孝泰, 森雄司, 田中健一, 鈴木聖子, 近藤康人, 宇理須厚雄
  • Organizer: 第26回日本アレルギー学会春季臨床大会
  • Place of Presentation: 京都
  • Year and Date: 20140000
• [Remarks] ホームページ等「低アレルゲン経口免疫療法」
  • URL: http://www.fujita-hu.ac.jp/~pedia/pg146.html