2013 Fiscal Year Final Research Report
Prevention of atherosclerosis by apple procyanidins and elucidation of their mechanism
| Project/Area Number |
23500996
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | National Agriculture and Food Research Organization |
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Principal Investigator |
SHOJI Toshihiko 独立行政法人農業・食品産業技術総合研究機構, 果樹研究所 栽培・流通利用研究領域, 主任研究員 (90582510)
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| Co-Investigator(Kenkyū-buntansha) |
MIURA Tomisato 国立大学法人, 弘前大学, 准教授 (20261456)
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| Project Period (FY) |
2011 – 2013
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| Keywords | リンゴ / プロシアニジン類 / 動脈硬化 / ApoE欠損マウス / RAW264.7細胞 |
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| Research Abstract |
We investigated the preventive effect of procyanidins, which is major phytochemicals in apple, on atherosclerosis in ApoE-deficient mice and 3T3-L1 cells. After the ingestion of high fat diet for 20 weeks, the body weight and mesenteric, perirenal, and testis fat weights in the high fat diet group significantly increased than those of normal diet group. And, thrombus-like structure was observed in vessel of mice of the high fat diet group. On the contrary, the increases of body weight and mesenteric, perirenal, and testis fat weights in the apple procyanidin group significantly inhibited than those of the high fat diet group. Furthermore, thrombus-like structure was observed in vessel of mice of the high fat diet group. Furthermore, APC prevented the exprresion of Aim gene in the ApoE-deficient mice and the secretion of TNF-a in RAW264.7 cells.
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