Are regulatory T cells related with resistance to Epidermal Growth Factor Receptor inhibitors?

2014 Fiscal Year Final Research Report

• Project/Area Number: 23501297
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor diagnosis
• Research Institution: Oita University
• Principal Investigator: WATANABE Koichiro 大分大学, 医学部, 助教 (00468000)
• Co-Investigator(Kenkyū-buntansha): SHIRAO Kuniaki 大分大学, 医学部, 教授 (10467996) ; HATANO Yutaka 大分大学, 医学部, 教授 (80336263) ; OOTSU Satoshi 大分大学, 医学部, 助教 (80437920) ; MORINAGA Ryotaro 大分大学, 医学部, 助教 (50411640) ; HIIRASHIMA Yoshinori 大分大学, 医学部, 助教 (60418837) ; HISAMATSU Yasushi 大分大学, 医学部, 助教 (00609670) ; NISHIKAWA Kazuo 大分大学, 医学部, 医員 (70636399) ; KAWANO Sakura 大分大学, 医学部, 医員 (40548137)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 獲得耐性 / 上皮成長因子受容体阻害薬 / 薬剤性皮膚障害 / ざ瘡様皮疹 / CTLA-4 / 制御性T細胞

Outline of Final Research Achievements

Our clinical study "The effect of regulatory T cells on resistance mechanism following the treatment with epidermal growth factor receptor inhibitors" was registered on University hospital Medical Information Network in Oct 1st 2012. Infiltration of regulatory T cells expressing FOXP3 and CTLA-4 into epidermis was observed in immunohistochemistry analysis. The Levels of CTLA-4 mRNA was upregulated depending on time in epidermis and circulating lymphocytes. However, it is difficult to enable proper aberration correction of inflammatory and regulatory cytokines from epidermis and circulating lymphocytes in the limited samples. The careful observation during the extended period would be needed in the further numbers of samples.

Free Research Field

臨床腫瘍学