2013 Fiscal Year Final Research Report
Synthesis of biologically important molecules by means of elencrochemical procedures
| Project/Area Number |
23510262
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Living organism molecular science
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 陽極酸化 / 陰極還元 / 有機電気化学 / ダイヤモンド電極 / 超原子価ヨウ素 / メトキシラジカル / 生物活性物質 / 電解酸 |
|---|
| Research Abstract |
A new synthetic methodology provided biologically important organic molecules by using environmentally benign electroorganic chemistry. Active species of anodic oxidation in methanol solvent employing the boron-doped diamond electrode, was determined to be a methoxy radical, and application of this electrode to organic synthesis produced several new molecules involving new-type neolignans. In addition, the core diary ether moiety of several bioactive substances was synthesized by successive electrochemical reactions. A new glycosidation was developed by reactions of extremely stable sugar orthoesters with appropriate aglycons in the presence of electrogenerated acid. As mentioned above,
new synthetic procedures using electric energy have been proposed.
|
