2014 Fiscal Year Final Research Report
GABAergic modulation on the oscillatory activity and network reconstruction in the slug olfactory center
| Project/Area Number |
23570099
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | GABA / oscillatory network / laminar structure / olfactory center / slug / cultured neuron |
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| Outline of Final Research Achievements |
Synchronous oscillatory activity is common in the olfactory behavior of both vertebrates and invertebrates. In the terrestrial slugs, periodic oscillation is recorded from the surface of the laminar structure of olfactory center, procerebrum (PC) and its frequency changes are suggested to encode the olfactory information and memory. Gamma-aminobutyric acid (GABA) neurons are known to inhibitory neurons as a kernel of rhythm generation in oscillatory networks of vertebrate. In the present study, we found that GABAergic neuron has a role to play as an excitatory modulator in the PC oscillatory network of the slugs. This observation and the conclusion have been supported by the pharmacological study in reconstructed oscillatory networks of cultured PC neurons.
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| Free Research Field |
神経生理学
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